Predictive value of 8 genetic loci for serum uric acid concentration

Scientific paper - Original scientific paper

• Author: Grgo Gunjača
• Author: Mladen Boban
• Author: Marina Pehlić
• Author: Tatijana Zemunik
• Author: Danijela Budimir
• Author: Ivana Kolčić
• Author: Gordan Lauc
• Author: Igor Rudan
• Author: Ozren Polašek
• Author's institution: University of Zagreb; School of Medicine
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences

Abstract (english)

Aim. To investigate the value of genomic information in prediction of individual serum uric acid concentrations. ----- Methods. Three population samples were investigated: from isolated Adriatic island communities of Vis (n=980) and Korcula (n=944), and from general population of the city of Split (n=507). Serum uric acid concentration was correlated with the genetic risk score based on 8 previously described genes: PDZK1, GCKR, SLC2A9, ABCG2, LRRC16A, SLC17A1, SLC16A9, and SLC22A12, represented by a total of 16 single-nucleotide polymorphisms (SNP). The data were analyzed using classification and regression tree (CART) and general linear modeling. ----- Results. The most important variables for uric acid prediction with CART were genetic risk score in men and age in women. The percent of variance for any single SNP in predicting serum uric acid concentration varied from 0.0%-2.0%. The use of genetic risk score explained 0.1%-2.5% of uric acid variance in men and 3.9%-4.9% in women. The highest percent of variance was obtained when age, sex, and genetic risk score were used as predictors, with a total of 30.9% of variance in pooled analysis. ----- Conclusion. Despite overall low percent of explained variance, uric acid seems to be among the most predictive human quantitative traits based on the currently available SNP information. The use of genetic risk scores is a valuable approach in genetic epidemiology and increases the predictability of human quantitative traits based on genomic information compared with single SNP approach.

• Keywords (english): Adult; Aged; Antioxidants; Croatia; Female; Genetic Loci; Genetic Testing; Genetics, Population / classification; Genotype; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide; Predictive Value of Tests; Uric Acid / blood
• Language: english
• Publication type: Scientific paper - Original scientific paper
• Publication status: Published
• Peer review: Peer review
• Publication version: Published version
• Journal title: Croatian Medical Journal
• Numbering: vol. 51, no. 1, pp. 23-31
• p-ISSN: 0353-9504
• DOI: https://doi.org/10.3325/cmj.2010.51.23
• URN:NBN: urn:nbn:hr:105:579367
• Publication: 2010-02-15
• Document URL: http://www.cmj.hr/2010/51/1/20162742.htm
• Type of resource: Text
• Access conditions: Open access
• Created on: 2024-03-28 11:30:50