Suvremene mogućnosti liječenja acne inversa

master's thesis

• Title (english): Current treatment options for acne inversa
• Author: Katarina Jordan
• Mentor: Zrinka Bukvić Mokos (mentor)
• Committee member: Romana Čeović (predsjednik povjerenstva)
• Committee member: ALEKSANDRA BASTA-JUZBAŠIĆ (član povjerenstva)
• Committee member: Zrinka Bukvić Mokos (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Dermatology); Zagreb
• Defense date and country: 2014-07-15, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Dermatovenerology

Abstract

Acne inversa je kronična recidivirajuća upalna bolest kože koja se najčešće
javlja u predjelu pazuha, prepona i anogenitalne regije. S obzirom na bol, neugodan
miris, gnojenje i estetske nedostatke zahvaćenih područja kože, ova bolest uvelike
utječe na kvalitetu života bolesnika. Acne inversa se najčešće javlja nakon
puberteta, s vrhuncem obolijevanja u ranim dvadesetim godinama. Procjenjuje se da
se bolest javlja tri puta češće u žena nego u muškaraca.
Etiopatogeneza acne inversa je po svemu sudeći multifaktorijalna. Primarnim
događajem se smatra okluzija terminalnog dlačnog folikula, koja je uzrokovana
hiperkeratozom i hiperplazijom folikularnog epitela. Okluzija rezultira akumulacijom
staničnog debrisa, formiranjem cisti i puknućem dlačnog folikula. U početnom
stadiju acne inversa je karakterizirana pojavom nježnih subkutanih čvorića koji
nalikuju na furunkul. S vremenom, čvorići se povećavaju i šire te često rupturiraju
pa nastaju duboki i bolni apscesi.
Liječenje acne inversa možemo podijeliti na nekirurško (medikamentozno),
kirurško i lasersko liječenje te njihovu kombinaciju. Oblik terapije ovisi o težini
bolesti odnosno stupnju zahvaćenosti kože. Antibiotici su osnovno uporište u
liječenju ove bolesti. Kirurško liječenje je jedina metoda kojom se postižu više stope
remisije ili izlječenje acne inversa. Svaki bolesnik zahtijeva jedinstven pristup
ovisno o stupnju njegove bolesti i toleranciji rizika.

Abstract (english)

Acne inversa is a chronic, recurrent and inflammatory skin disease that usually
occurs on the skin of the axilla, groin, and anogenital regions. Due to pain, odor,
pus and aesthetic deficiencies of the affected areas, disease greatly affects the
patients' quality of life. Acne inversa usually appears after puberty. Disease occurs
more often in women than in men.
Ethiopathogenesis of acne inversa is multifactorial. The primary event seems to
be occlusion of the terminal hair follicle, which is caused by hyperkeratosis and
hyperplasia of follicular epithelium. However, the result of occlusion is accumulation
of cellular debris, forming cysts and rupture of hair follicle. In the initial stage, acne
inversa is characterized by the appearance of soft subcutaneous nodules that
resemble furuncule. Over time, the nodules progressively increase and spread, they
rupture and finally form deep painful abscesses. The rupture often leads to drainage
of purulent content odor.
Treatment of acne inversa can be divided into non-surgical, surgical and laser
treatment, and combination of aforementioned methods. The form of treatment
depends on the type and degree of involvement of the skin. Mainstay treatment for
acne inversa are antibiotics. Surgery is the only therapeutic option that leads to
higher rates of complete repression of acne inversa. However, every patient is
different and requires the unique approach based on the stage of his disease and
the tolerance of the risk.

• Keywords: acne inversa; etiopatogeneza; liječenje
• Keywords (english): acne inversa; etiopathogenesis; treatment
• Language: croatian
• URN:NBN: urn:nbn:hr:105:704813
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2015-10-06 08:25:39