prikaz prve stranice dokumenta Association study of a functional catechol-o-methyltransferase polymorphism and smoking in healthy Caucasian subjects
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Scientific paper - Original scientific paper
Association study of a functional catechol-o-methyltransferase polymorphism and smoking in healthy Caucasian subjects
Neuroscience Letters, 473 (2010), 3; 216-219. https://doi.org/10.1016/j.neulet.2010.02.050
Nedić, Gordana; Matea Nikolac, Matea; Borovečki, Fran; Hajnšek, Sanja; Muck-Šeler, Dorotea; Pivac, Nela

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Nedić, G., Matea Nikolac, M., Borovečki, F., Hajnšek, S., Muck Šeler, D. & Pivac, N. (2010). Association study of a functional catechol-o-methyltransferase polymorphism and smoking in healthy Caucasian subjects. Neuroscience Letters, 473. (3), 216-219. doi: 10.1016/j.neulet.2010.02.050

Nedić, Gordana, et al. "Association study of a functional catechol-o-methyltransferase polymorphism and smoking in healthy Caucasian subjects." Neuroscience Letters, vol. 473, no. 3, 2010, pp. 216-219. https://doi.org/10.1016/j.neulet.2010.02.050

Nedić, Gordana, Matea Matea Nikolac, Fran Borovečki, Sanja Hajnšek, Dorotea Muck Šeler and Nela Pivac. "Association study of a functional catechol-o-methyltransferase polymorphism and smoking in healthy Caucasian subjects." Neuroscience Letters 473, no. 3 (2010): 216-219. https://doi.org/10.1016/j.neulet.2010.02.050

Nedić, G., et al. (2010) 'Association study of a functional catechol-o-methyltransferase polymorphism and smoking in healthy Caucasian subjects', Neuroscience Letters, 473(3), pp. 216-219. doi: 10.1016/j.neulet.2010.02.050

Nedić G, Matea Nikolac M, Borovečki F, Hajnšek S, Muck Šeler D, Pivac N. Association study of a functional catechol-o-methyltransferase polymorphism and smoking in healthy Caucasian subjects. Neuroscience Letters [Internet]. 2010 April 12 [cited 2024 April 11];473(3):216-219. doi: 10.1016/j.neulet.2010.02.050

G. Nedić, M. Matea Nikolac, F. Borovečki, S. Hajnšek, D. Muck Šeler and N. Pivac, "Association study of a functional catechol-o-methyltransferase polymorphism and smoking in healthy Caucasian subjects", Neuroscience Letters, vol. 473, no. 3, pp. 216-219, April 2010. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:782475. [Accessed: 11 April 2024]

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Metadata
Title (english)Association study of a functional catechol-o-methyltransferase polymorphism and smoking in healthy Caucasian subjects
AuthorGordana Nedić
AuthorMatea Matea Nikolac
AuthorFran Borovečki
AuthorSanja Hajnšek
AuthorDorotea Muck-Šeler
AuthorNela Pivac
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Tobacco smoking is a global health problem. The association of a functional common polymorphism in the catechol-o-methyltransferase gene (COMT Val158Met) with smoking behavior has been extensively studied, but with divergent findings. In the present study the frequency of COMT genotypes and alleles was evaluated in 578 male and a smaller group of 79 female unrelated, medication-free Caucasian healthy subjects of Croatian origin. Smokers were classified as subjects smoking </=10 cigarettes per day, while subjects who never smoked in their life were regarded as nonsmokers. A chi(2)-test with standardized residuals and Bonferroni correction revealed significant (P=0.017) differences in Met/Met, Met/Val or Val/Val genotype frequency between male smokers and nonsmokers. This significant association between COMT Val158Met polymorphism and smoking was not detected in female subjects, due to the small number of women, which represents a limitation of the study. Our results confirmed the significant association between COMT variants and smoking, which was due to the higher frequency of Val/Val homozygotes in male smokers compared to male nonsmokers. These results suggest that carriers of the high activity COMT variant are more prone to develop a higher level of nicotine dependence, or that they release more dopamine than carriers of Met/Met or Met/Val genotypes.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleNeuroscience Letters
Numberingvol. 473, no. 3, pp. 216-219
p-ISSN0304-3940
DOIhttps://doi.org/10.1016/j.neulet.2010.02.050
URN:NBNurn:nbn:hr:105:782475
Publication2010-04-12
Document URLhttps://doi.org/10.1016/j.neulet.2010.02.050
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 11:35:33