Cytogenetics of multiple myeloma

Scientific paper - Original scientific paper

• Title (croatian): Citogenetski rezultati 24 slučajeva multiplog mieloma
• Author: Ružica Lasan Trčić
• Author: Ika Kardum Skelin
• Author: Dunja Šušterčić
• Author: Ana Planinc-Peraica
• Author: Radmila Ajduković
• Author: Višnja Hariš
• Author: Rajko Kušec
• Author: Davor Begović
• Author's institution: University of Zagreb; School of Medicine
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences

Abstract (english)

Great studies of multiple myeloma (MM) strongly suggested that specific chromosomal changes are of prognostic significance in patients with MM1. We have performed cytogenetic analysis and recently fluorescent in situ hybridization (FISH) on 43 cases of MM. Clonal chromosomal changes were present in 24 (56%) cases. Hyperdiploid karyotype was found in 12 (50%) cases, hypodiploid in 8 (33%) cases, and 4 (17%) cases had a pseudodiploid karyotype. The most common numerical abnormalities were gains of whole chromosomes 15, 11, 3 and 6. Whole chromosome losses were also frequent involving chromosomes X, 13, 14, and 8. Most cases showed also structural rearrangements 71% (n=17): del(1p), dup(1q), del(5q), del(13q), del(17p) and t(11;14)(q13;q32) (n=4, 17%). Chromosome –13/13q deletion was found in 42% (n=10) cases; complete loss of 13 was observed in 67% (n=7) cases, whereas 33% (n=3) had interstitial deletions. In the majority of the cases there was a mixture of abnormal and normal metaphases.

Abstract (croatian)

Velika ispitivanja multiplog mieloma (MM) naglašavaju da su određene kromosomske promjene od indikativnog značaja za pacijente s MM. Izvršili smo citogenetičke analize, a i u novije vrijeme i florescentnu in situ hibridizaciju (FISH) na 43 slučaja sa MM. Klonske kromosomske promjene bile su prisutne kod 24 (56%) slučaja. Hiperdiploidni kariotip je nađen kod 12 (50%) slučaja, hipodiploidni kod 8 (33%) slučaja, i 4 (17%) slučaja imalo je pseudodiploidni kariotip. Najčešće brojčane nepravilnosti bile su suvišci kromosoma 15, 11, 3 i 6. Manjak čitavih kromosoma bili su česti kod kromosoma X, 13, 14, i 8. Većina slučajeva također je pokazala strukturalne preuredbe 71% (n=17): del(1p), dup(1q), del(5q), del(13q), del(17p) and t (11;14)(q13;q32) (n=4,17%). Kromosom – 13/13q delecija nađen je u 42% (n=10) slučaja, potpuni gubitak kromosoma 13 uočen je kod 67% (n=7) slučaja, dok je 33% (n=3) bilo s intersticijskom delecijom. U većini slučajeva bile su uz abnormalne prisutne i normalne metafaze.

• Keywords (english): Aged; Aged, 80 and over; Aneuploidy; Biopsy, Needle; Bone Marrow/pathology; Chromosome Aberrations; Chromosome Banding; Chromosome Deletion; Female; Gene Rearrangement; Humans; In Situ Hybridization, Fluorescence; Karyotyping; Male; Middle Aged; Multiple Myeloma/genetics; Multiple Myeloma/pathology; Prognosis; Translocation, Genetic
• Language: english
• Publication type: Scientific paper - Original scientific paper
• Publication status: Published
• Peer review: Peer review
• Publication version: Published version
• Journal title: Collegium Antropologicum
• Numbering: vol. 34, no. 1, pp. 41-44
• p-ISSN: 0350-6134
• URN:NBN: urn:nbn:hr:105:444114
• Publication: 2010-03
• Document URL: https://hrcak.srce.hr/51239
• Type of resource: Text
• Access conditions: Open access
• Created on: 2024-03-28 11:44:13