prikaz prve stranice dokumenta Immunohistochemical expression of tumor antigens MAGE-A3/4 and NY-ESO-1 in renal oncocytoma and chromophobe renal cell carcinoma
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Scientific paper - Original scientific paper
Immunohistochemical expression of tumor antigens MAGE-A3/4 and NY-ESO-1 in renal oncocytoma and chromophobe renal cell carcinoma
Pathology, Research and Practice, 206 (2010), 10; 695-699. https://doi.org/10.1016/j.prp.2010.05.013
Demirović, Alma; Džombeta, Tihana; Tomas, Davor; Spajić, Borislav; Pavić, Ivana; Hudolin, Tvrtko; Milošević, Milan; Čupić, Hrvoje; Krušlin, Božo

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Demirović, A., Džombeta, T., Tomas, D., Spajić, B., Pavić, I., Hudolin, T. ... Krušlin, B. (2010). Immunohistochemical expression of tumor antigens MAGE-A3/4 and NY-ESO-1 in renal oncocytoma and chromophobe renal cell carcinoma. Pathology, Research and Practice, 206. (10), 695-699. doi: 10.1016/j.prp.2010.05.013

Demirović, Alma, et al. "Immunohistochemical expression of tumor antigens MAGE-A3/4 and NY-ESO-1 in renal oncocytoma and chromophobe renal cell carcinoma." Pathology, Research and Practice, vol. 206, no. 10, 2010, pp. 695-699. https://doi.org/10.1016/j.prp.2010.05.013

Demirović, Alma, Tihana Džombeta, Davor Tomas, Borislav Spajić, Ivana Pavić, Tvrtko Hudolin, Milan Milošević, Hrvoje Čupić and Božo Krušlin. "Immunohistochemical expression of tumor antigens MAGE-A3/4 and NY-ESO-1 in renal oncocytoma and chromophobe renal cell carcinoma." Pathology, Research and Practice 206, no. 10 (2010): 695-699. https://doi.org/10.1016/j.prp.2010.05.013

Demirović, A., et al. (2010) 'Immunohistochemical expression of tumor antigens MAGE-A3/4 and NY-ESO-1 in renal oncocytoma and chromophobe renal cell carcinoma', Pathology, Research and Practice, 206(10), pp. 695-699. doi: 10.1016/j.prp.2010.05.013

Demirović A, Džombeta T, Tomas D, Spajić B, Pavić I, Hudolin T, and sur.. Immunohistochemical expression of tumor antigens MAGE-A3/4 and NY-ESO-1 in renal oncocytoma and chromophobe renal cell carcinoma. Pathology, Research and Practice [Internet]. 2010 October 15 [cited 2024 April 12];206(10):695-699. doi: 10.1016/j.prp.2010.05.013

A. Demirović, et al., "Immunohistochemical expression of tumor antigens MAGE-A3/4 and NY-ESO-1 in renal oncocytoma and chromophobe renal cell carcinoma", Pathology, Research and Practice, vol. 206, no. 10, pp. 695-699, October 2010. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:095787. [Accessed: 12 April 2024]

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Title (english)Immunohistochemical expression of tumor antigens MAGE-A3/4 and NY-ESO-1 in renal oncocytoma and chromophobe renal cell carcinoma
AuthorAlma Demirović
AuthorTihana Džombeta
AuthorDavor Tomas
AuthorBorislav Spajić
AuthorIvana Pavić
AuthorTvrtko Hudolin
AuthorMilan Milošević
AuthorHrvoje Čupić
AuthorBožo Krušlin
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
The distinction between renal oncocytoma (RO) and chromophobe renal cell carcinoma (ChRCC), especially the eosinophilic variant, can often be difficult. Our study has documented for the first time the expression of MAGE-A3/4 and NY-ESO-1 cancer testis antigens (CTAs) in these tumors. A total of 35 patients (17 ROs and 18 ChRCCs) were included in the study. Two antibodies were used for immunohistochemical staining: 57B recognizing multiple MAGE-A and D8.38 recognizing NY-ESO-1 CTAs. Fifteen (88.2%) samples of RO stained positively for both MAGE-A3/4 and NY-ESO-1 antigens. Regarding ChRCC, seven (38.9%) stained positively for MAGE-A3/4 and six (33.3%) for NY-ESO-1 antigens. Median MAGE-A3/4 expression was moderately positive in RO and negative in ChRCC. The difference in MAGE-A3/4 expression between two tumor groups was significant (P=0.0013). Median NY-ESO-1 expression was strongly positive in RO and negative in ChRCC. The difference in NY-ESO-1 expression between two tumor groups was also significant (P=0.0008). Our study has shown that RO had a significantly higher expression of both CTAs. However, additional research is needed to clarify their potential diagnostic implications.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titlePathology, Research and Practice
Numberingvol. 206, no. 10, pp. 695-699
p-ISSN0344-0338
DOIhttps://doi.org/10.1016/j.prp.2010.05.013
URN:NBNurn:nbn:hr:105:095787
Publication2010-10-15
Document URLhttps://doi.org/ Gustav Fischer Verlag
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 11:45:54