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Scientific paper - Original scientific paper
Vascular endothelial growth factor and intratumoral microvessel density as prognostic factors in endometrial cancer
Collegium Antropologicum, 34 (2010), 2; 447-453. urn:nbn:hr:105:513145
Topolovec, Zlatko; Ćorušić, Ante; Babić, Damir; Mrčela, Milanka; Šijanović, Siniša; Müller-Vranješ, Andrijana; Čuržik, Darko

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Topolovec, Z., Ćorušić, A., Babić, D., Mrčela, M., Šijanović, S., Müller Vranješ, A. & Čuržik, D. (2010). Vascular endothelial growth factor and intratumoral microvessel density as prognostic factors in endometrial cancer . Collegium Antropologicum, 34. (2), 447-453. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:513145

Topolovec, Zlatko, et al. "Vascular endothelial growth factor and intratumoral microvessel density as prognostic factors in endometrial cancer ." Collegium Antropologicum, vol. 34, no. 2, 2010, pp. 447-453. https://urn.nsk.hr/urn:nbn:hr:105:513145

Topolovec, Zlatko, Ante Ćorušić, Damir Babić, Milanka Mrčela, Siniša Šijanović, Andrijana Müller Vranješ and Darko Čuržik. "Vascular endothelial growth factor and intratumoral microvessel density as prognostic factors in endometrial cancer ." Collegium Antropologicum 34, no. 2 (2010): 447-453. https://urn.nsk.hr/urn:nbn:hr:105:513145

Topolovec, Z., et al. (2010) 'Vascular endothelial growth factor and intratumoral microvessel density as prognostic factors in endometrial cancer ', Collegium Antropologicum, 34(2), pp. 447-453. Available at: https://urn.nsk.hr/urn:nbn:hr:105:513145 (Accessed 05 May 2024)

Topolovec Z, Ćorušić A, Babić D, Mrčela M, Šijanović S, Müller Vranješ A, and sur.. Vascular endothelial growth factor and intratumoral microvessel density as prognostic factors in endometrial cancer . Collegium Antropologicum [Internet]. 2010 June [cited 2024 May 05];34(2):447-453. Available at: https://urn.nsk.hr/urn:nbn:hr:105:513145

Z. Topolovec, et al., "Vascular endothelial growth factor and intratumoral microvessel density as prognostic factors in endometrial cancer ", Collegium Antropologicum, vol. 34, no. 2, pp. 447-453, June 2010. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:513145. [Accessed: 05 May 2024]

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Metadata
Title (english)Vascular endothelial growth factor and intratumoral microvessel density as prognostic factors in endometrial cancer
Title (croatian)Vaskularni endotelni čimbenik rasta i gustoća tumorskih kapilara kao prognostički čimbenik u endometrijskom raku
AuthorZlatko Topolovec
AuthorAnte Ćorušić
AuthorDamir Babić
AuthorMilanka Mrčela
AuthorSiniša Šijanović
AuthorAndrijana Müller-Vranješ
AuthorDarko Čuržik
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
The aim of this research was to determine the VEGF A expression in tumor cells and the intratumoral microvessel density and their prognostic significance in the survival of the subjects. 87 subjects were monitored retrospectively for a period of 60 to 132 months. The subjects were treated at the Department of Obstetrics and Gynecology of Osijek University Hospital Center, Croatia. We analysed standard clinical, pathohistological and therapeutical prognostic factors, intratumoral microvessel density and expression of VEGF A. Five-year survival was calculated by the life chart method and presented graphically by Kaplan-Meier curves. Reaching conclusions on statistical hypotheses in this paper was done with a reliability level p < 0.05. Of the analyzed clinical prognostic factors, those which proved to be statistically significant and independent prognostic factors were age and clinical stage of the disease, and of pathohistologic ones it was the depth of myometrial invasion and VEGF expression. An elevated VEGF expression is associated with deep myometrial invasion, poorly differentiated tumors, histologic type and intratumoral microvessel density to a statistically significant degree. Elevated VEGF expression, age, FIGO stage and depth of myometrial invasion play a significant prognostic role in patients with endometrial cancer. VEGF receptors could be a target for adjuvant therapy in VEGF positive endometrial cancer.
Abstract (croatian)
Cilj ovog istraživanja bio je odrediti genski izražaj VEGF A u tumorskim stanicama i vrijednosti tumorske gustoće kapilara i njihov prognostički značaj za preživljenje ispitanica. Retrospektivno je kroz period od 60 do 132 mjeseca praćeno 87 ispitanica, liječenih u Odjelu za ginekologiju i porodništvo Kliničke bolnice Osijek, Hrvatska. Analizirali smo standardne kliničke, patohistološke i terapijske prognostičke čimbenike, gustoću tumorskih kapilara i izražaj VEGF A. Vjerojatnost preživljenja računali smo metodom životnih tablica i prikazali je grafički Kaplan-Meierovim krivuljama. Zaključivanje o statističkim hipotezama u ovom je radu provedeno uz razinu sigurnosti p<0,05. Od analiziranih klini- čkih prognostičkih čimbenika statistički značajnim i neovisnim prognostičkim čimbenicima pokazali su se dob i klinički stadij bolesti, a od patohistoloških, dubina miometrijske invazije i izražaj VEGF-a. Povišen izražaj VEGF-a statistički je značajno povezan s dubokom miometrijskom invazijom, slabo diferenciranim tumorima, histološkim tipom tumora i gustoćom tumorskih kapilara. Povećan genski izražaj VEGF-a, dob, FIGO stadij i dubina miometrijske invazije imaju značajnu prognostičku ulogu u bolesnica s endometrijskim rakom. VEGF receptori bi mogli biti meta adjuvantne terapije u VEGF pozitivnim karcinomima endometrija.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCollegium Antropologicum
Numberingvol. 34, no. 2, pp. 447-453
p-ISSN0350-6134
URN:NBNurn:nbn:hr:105:513145
Publication2010-06
Document URLhttps://hrcak.srce.hr/56464
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 11:46:07