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Scientific paper - Original scientific paper
A view at the future - a dynamical, protocol-based and computationally intensive approach in cardiovascular risk assessment
Collegium Antropologicum, 34 (2010), 2; 437-445. urn:nbn:hr:105:233172
Majnarić-Trtica, Ljiljana; Vitale, Branko; Martinis, Mladen; Reiner, Željko

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Majnarić Trtica, Lj., Vitale, B., Martinis, M. & Reiner, Ž. (2010). A view at the future - a dynamical, protocol-based and computationally intensive approach in cardiovascular risk assessment . Collegium Antropologicum, 34. (2), 437-445. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:233172

Majnarić Trtica, Ljiljana, et al. "A view at the future - a dynamical, protocol-based and computationally intensive approach in cardiovascular risk assessment ." Collegium Antropologicum, vol. 34, no. 2, 2010, pp. 437-445. https://urn.nsk.hr/urn:nbn:hr:105:233172

Majnarić Trtica, Ljiljana, Branko Vitale, Mladen Martinis and Željko Reiner. "A view at the future - a dynamical, protocol-based and computationally intensive approach in cardiovascular risk assessment ." Collegium Antropologicum 34, no. 2 (2010): 437-445. https://urn.nsk.hr/urn:nbn:hr:105:233172

Majnarić Trtica, Lj., et al. (2010) 'A view at the future - a dynamical, protocol-based and computationally intensive approach in cardiovascular risk assessment ', Collegium Antropologicum, 34(2), pp. 437-445. Available at: https://urn.nsk.hr/urn:nbn:hr:105:233172 (Accessed 15 April 2024)

Majnarić Trtica Lj, Vitale B, Martinis M, Reiner Ž. A view at the future - a dynamical, protocol-based and computationally intensive approach in cardiovascular risk assessment . Collegium Antropologicum [Internet]. 2010 June [cited 2024 April 15];34(2):437-445. Available at: https://urn.nsk.hr/urn:nbn:hr:105:233172

Lj. Majnarić Trtica, B. Vitale, M. Martinis and Ž. Reiner, "A view at the future - a dynamical, protocol-based and computationally intensive approach in cardiovascular risk assessment ", Collegium Antropologicum, vol. 34, no. 2, pp. 437-445, June 2010. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:233172. [Accessed: 15 April 2024]

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Metadata
Title (english)A view at the future - a dynamical, protocol-based and computationally intensive approach in cardiovascular risk assessment
Title (croatian)Pogled u budućnost: dinamički pristup procjene kardiovaskularnog rizika, temeljen na protoku i upotrebi kompjutera
AuthorLjiljana Majnarić-Trtica
AuthorBranko Vitale
AuthorMladen Martinis
AuthorŽeljko Reiner
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Knowledge of cardiovascular risk factors is increasing. At the same time, risk estimation becomes more and more difficult. The need for a more comprehensive, but more individually based approach is evident. To achieve this aim, we propose a systems biology approach in cardiovascular risk assessment. This means that a large amount of health data, describing many aspects of the health-status of patients, is collected and computed and the results are compared with existing knowledge. Finally, a clinical model is created, which can be the first step in ongoing research protocol, aimed at assessing cardiovascular risk. By using this approach, all potentially relevant risk factors can be identified on a small sample. Moreover, risk groups can be more specifically defined, based on the "natural" clustering of data, according to their predictive load. We tested this possibility on an example of hyperhomocysteinemia which is a well-known complex cardiovascular risk factor.
Abstract (croatian)
Znanje o kardiovaskularnim čimbenicima rizika se stalno povećava. Shodno tome, postupak procjene kardiovaskularnog rizika postaje sve kompliciraniji. Javlja se zahtjev za što obuhvatnijim, ali i što više individualiziranim pristupom. Kao način postizanja toga cilja, za procjenu kardiovaskularnog rizika predlažemo pristup s aspekta sustavne biologije. To znači potrebu prikupljanja velikog broja podataka, da bi se opisalo zdravstveno stanje pacijenata. Te podatke treba obraditi naprednim kompjuterskim metodama i usporediti s postojećim znanjem. Konačni cilj toga postupka je kreiranje kliničkog modela, što je tek prvi korak cikličkog protokola koji za krajnji cilj ima procjenu kardiovaskularnog rizika. Takvim pristupom bi se mogli identificirati svi potencijalno važni čimbenici rizika na malom uzorku ispitanika. Štoviše, zbog »prirodnog« grupiranja podataka, na temelju njihove prediktivne vrijednosti, na taj način bi se mogle specifičnije definirati rizične skupine pacijenata. Takvu mogućnost smo testirali na primjeru hiperhomocisteinemije, što je poznati kompleksni čimbenik povećanog kardiovaskularnog rizika.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCollegium Antropologicum
Numberingvol. 34, no. 2, pp. 437-445
p-ISSN0350-6134
URN:NBNurn:nbn:hr:105:233172
Publication2010-06
Document URLhttps://hrcak.srce.hr/56461
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 11:47:24