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Scientific paper - Original scientific paper
Hypercoagulability in Cushing's syndrome: the role of specific haemostatic and fibrinolytic markers
Endocrine, 36 (2009), 1; 70-74. https://doi.org/10.1007/s12020-009-9186-y
Kaštelan, Darko; Dušek, Tina; Kraljević, Ivana; Polašek, Ozren; Giljević, Zlatko; Solak, Mirsala; Zupančić Šalek, Silva; Jelčić, Jozo; Aganović, Izet; Koršić, Mirko

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Kaštelan, D., Dušek, T., Kraljević, I., Polašek, O., Giljević, Z., Solak, M. ... Koršić, M. (2009). Hypercoagulability in Cushing's syndrome: the role of specific haemostatic and fibrinolytic markers. Endocrine, 36. (1), 70-74. doi: 10.1007/s12020-009-9186-y

Kaštelan, Darko, et al. "Hypercoagulability in Cushing's syndrome: the role of specific haemostatic and fibrinolytic markers." Endocrine, vol. 36, no. 1, 2009, pp. 70-74. https://doi.org/10.1007/s12020-009-9186-y

Kaštelan, Darko, Tina Dušek, Ivana Kraljević, Ozren Polašek, Zlatko Giljević, Mirsala Solak, Silva Zupančić Šalek, Jozo Jelčić, Izet Aganović and Mirko Koršić. "Hypercoagulability in Cushing's syndrome: the role of specific haemostatic and fibrinolytic markers." Endocrine 36, no. 1 (2009): 70-74. https://doi.org/10.1007/s12020-009-9186-y

Kaštelan, D., et al. (2009) 'Hypercoagulability in Cushing's syndrome: the role of specific haemostatic and fibrinolytic markers', Endocrine, 36(1), pp. 70-74. doi: 10.1007/s12020-009-9186-y

Kaštelan D, Dušek T, Kraljević I, Polašek O, Giljević Z, Solak M, and sur.. Hypercoagulability in Cushing's syndrome: the role of specific haemostatic and fibrinolytic markers. Endocrine [Internet]. 2009 August [cited 2024 November 29];36(1):70-74. doi: 10.1007/s12020-009-9186-y

D. Kaštelan, et al., "Hypercoagulability in Cushing's syndrome: the role of specific haemostatic and fibrinolytic markers", Endocrine, vol. 36, no. 1, pp. 70-74, August 2009. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:887716. [Accessed: 29 November 2024]

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Metadata
Title (english)Hypercoagulability in Cushing's syndrome: the role of specific haemostatic and fibrinolytic markers
AuthorDarko Kaštelan
AuthorTina Dušek
AuthorIvana Kraljević
AuthorOzren Polašek
AuthorZlatko Giljević
AuthorMirsala Solak
AuthorSilva Zupančić Šalek
AuthorJozo Jelčić
AuthorIzet Aganović
AuthorMirko Koršić
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
OBJECTIVE: Hypercoagulability is a commonly described complication in patients with Cushing's syndrome. Recent clinical studies have indicated various abnormalities of coagulation and fibrinolysis parameters which may be related to that phenomenon. The aim of this study was to investigate the mechanisms underlying the hypercoagulable state in patients with Cushing's syndrome. ----- RESEARCH METHODS AND PROCEDURES: A wide range of serum markers involved in the processes of blood coagulation and fibrinolysis was measured in a group of 33 patients with Cushing's syndrome and 31 healthy controls. No participant was taking medication which could influence the result or had known diseases, except hypertension and diabetes, which could affect blood coagulation or fibrinolysis parameters. ----- RESULTS: Patients with Cushing's syndrome had higher levels of clotting factors II (P = 0.003), V (P < 0.001), VIII (P < 0.001), IX (P < 0.001), XI (P < 0.001) and XII (P = 0.019), protein C (P < 0.001), protein S (P < 0.001), C1-inhibitor (P < 0.001) and plasminogen activator inhibitor-1 (PAI-1) (P = 0.004). The activity of fibrinolytic markers, plasminogen (P < 0.001), antithrombin (P < 0.001) and antithrombin antigen (P = 0.001) was also increased in the patient group. ----- CONCLUSION: The study has demonstrated hypercoagulability in patients with Cushing's syndrome manifest as increased prothrombotic activity and compensatory activation of the fibrinolytic system. We propose the introduction of thromboprophylaxis in the preoperative and early postoperative periods, combined with a close follow-up in order to prevent possible thromboembolic events in patients with Cushing's syndrome.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleEndocrine
Numberingvol. 36, no. 1, pp. 70-74
p-ISSN1355-008X
DOIhttps://doi.org/10.1007/s12020-009-9186-y
URN:NBNurn:nbn:hr:105:887716
Publication2009-08
Document URLhttps://doi.org/10.1007/s12020-009-9186-y
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 11:49:31