Serum immunoglobulins in non-Hodgkin's lymphoma patients

Scientific paper - Original scientific paper

• Title (croatian): Serumski imunoglobulini u bolesnika sa ne-Hodgkinovim limfomom
• Author: Ana Planinc-Peraica
• Author: Slobodanka Ostojić Kolonić
• Author: Delfa Radić-Krišto
• Author: Mara Dominis
• Author: Branimir Jakšić
• Author's institution: University of Zagreb; School of Medicine
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences

Abstract (english)

Serum proteins and immunoglobulin (Ig) findings in 119 non-Hodgkin's lymphoma (NHL) patients were analysed. Out of them 96 (81%) patients had B non-Hodgkin lymphoma (B-NHL), and 23 (19%) T-NHL. Indolent type of NHL was more frequent (77 patients, 65%), then aggressive type of NHL (42 patients, 35%). Most patients had normal serum protein concentration, the increased protein concentration was seen in 17% of patients while decreased concentration was noticed in 7% of patients. Hypoalbuminaemia was more frequent (43%) then hyperalbuminaemia (1%). In contrast to albumin, low levels of other protein fractions (alpha1-, alpha2-, and beta-globulin) were rather rare (0.6%, 4%, and 3% of patients, respectively) and high levels were frequent (23%, 37%, and 8%, respectively). Polyclonal hyperimmunoglobulinaemia was more frequent finding than hypoimmunoglobulinaemia. In 29% patients higher IgG level and in 25% patients higher IgA level were found. IgM hypoimmunoglobulinaemia (22%) was more frequent than IgG (11%) and IgA (8%) hypoimmunoglobulinaemia. M-spike in serum protein electrophoresis was found in 11 (7%) patients. The statistically significant association was not found between serum Ig concentration and lymphoma malignancy grade as well as between serum Ig concentration and immunologic origin of lymphoma. T-NHL patients have more often IgA concentration level above or under normal values than B-NHL patients (p < 0.05).

Abstract (croatian)

Analizirali smo nalaze serumskih bjelančevina i imunoglobulina (Ig) u 119 bolesnika sa ne-Hodgkinovim limfomom (NHL). U 96 (81%) bolesnika dijagnosticiran je B-NHL, a u 23 (19%) T-NHL, mnogo češće indolentni tip (77 bolesnika, 65%), nego agresivni tip (42 bolesnika, 35%). U većine bolesnika koncentracija serumskih bjelančevina je bila u granicama normale. Povišena koncentracija serumskih bjelančevina je nađena u 17%, a snižena u 7% bolesnika. Hipoalbuminemija je mnogo češća (43%) nego hiperalbuminemija (1%). Za razliku od serumskog albumina, niske razine drugih proteinskih frakcija su vrlo rijetke (0.6% bolesnika ima snižene alfa1-, 4% bolesnika ima snižene alfa-2 i 3% bolesnika ima snižene beta-globuline), a povišene znatno češće (23% alfa-1, 37% alfa-2 i 8% beta-globulini). Poliklonalna hiperimunoglobulinemija je češća nego hipoimunoglobulinemija. U 29% bolesnika nađena je povišena razina IgG i u 25% bolesnika povišena razina IgA. Hipoimunoglobuinemija IgM (22%) je mnogo češća nego IgG (11%) i IgA (8%). U 11 (7%) bolesnika u elektroforezi serumskih bjelančevina nađena je monoklonalna gamapatija. Nije nađena statistički značajna povezanost između koncentracije serumskih imunoglobulina i stupnja malignosti limfoma kao niti između koncentracije serumskih imunoglobulina i imunološkog porijekla limfoma. Bolesnici sa T-NHL imaju češće koncentraciju IgA iznad ili ispod normalnih vrijednosti nego bolesnici s B-NHL (p<0,05).

• Keywords (english): Adult; Blood Proteins/analysis; Humans; Immunoglobulin A/blood; Immunoglobulin G/blood; Immunoglobulin M/blood; Immunoglobulins/blood; Lymphoma, Non-Hodgkin/blood; Lymphoma, Non-Hodgkin/immunology; Lymphoma, Non-Hodgkin/pathology; Retrospective Studies; Serum Albumin/metabolism; Serum Globulins/metabolism
• Language: english
• Publication type: Scientific paper - Original scientific paper
• Publication status: Published
• Peer review: Peer review
• Publication version: Published version
• Journal title: Collegium Antropologicum
• Numbering: vol. 34, no. 2, pp. 407-411
• p-ISSN: 0350-6134
• URN:NBN: urn:nbn:hr:105:464851
• Publication: 2010-06
• Document URL: https://hrcak.srce.hr/56448
• Type of resource: Text
• Access conditions: Open access
• Created on: 2024-03-28 11:53:48