Physical characteristics in the new model of the cerebrospinal fluid system

Scientific paper - Original scientific paper

• Title (croatian): Fizikalne osobine novog modela cerebrospinalnog likvora
• Author: Ivana Jurjević
• Author: Milan Radoš
• Author: Janko Orešković
• Author: Radovan Prijić
• Author: Ante Tvrdeić
• Author: Marijan Klarica
• Author's institution: University of Zagreb; School of Medicine
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Basic Medical Sciences

Abstract (english)

It is unknown which factors determine the changes in cerebrospinal fluid (CSF) pressure inside the craniospinal system during the changes of the body position. To test this, we have developed a new model of the CSF system, which by its biophysical characteristics and dimensions imitates the CSF system in cats. The results obtained on a model were compared to those in animals observed during changes of body position. A new model was constructed from two parts with different physical characteristics. The »cranial« part is developed from a plastic tube with unchangeable volume, while the »spinal« part is made of a rubber baloon, with modulus of elasticity similar to that of animal spinal dura. In upright position, in the »cranial« part of the model the negative pressure appears without any measurable changes in the fluid volume, while in »spinal« part the fluid pressure is positive. All of the observed changes are in accordance to the law of the fluid mechanics. Alterations of the CSF pressure in cats during the changes of the body position are not significantly different compared to those observed on our new model. This suggests that the CSF pressure changes are related to the fluid mechanics, and do not depend on CSF secretion and circulation. It seems that in all body positions the cranial volume of blood and CSF remains constant, which enables a good blood brain perfusion.

Abstract (croatian)

Nije poznato koji sve čimbenici uvjetuju promjene tlaka likvora unutar kraniospinalnog sustava pri promjeni položaja tijela. Kako bismo to ispitali izradili smo novi model likvorskog sustava koji svojim biofizičkim karakteristikama i dimenzijama imitira likvorski sustav u mačaka te usporedili rezultate dobivene na modelu i životinjama pri promjeni položaja iz horizontalnog u uspravni. Novi model je izrađen iz dva dijela. »Kranijski« dio je izrađen od plastične cijevi i ne može mijenjati svoj volumen, dok je »spinalni« dio izrađen od duguljastog gumenog balona sličnog elastičnog modula kao spinalna dura pa može mijenjati volumen u svakom segmentu. Pri uspravljanju modela u »kranijskom« dijelu dolazi do pojave negativnog tlaka bez promjene volumena tekućine unutar tog prostora, a u »spinalnom« dijelu tlak tekućine odgovara visini hidrostatskog tlaka što je u skladu s zakonom o mehanici fluida. Promjene tlaka likvora kod promjene položaja mačke ne razlikuju se od promjena tlaka tekućine opažene u modelu. To ukazuje kako su promjene tlaka likvora odvijaju u skladu s zakonom o mehanici fluida i ne ovise o sekreciji i cirkulaciji likvora.

• Keywords (english): Animals; Cats; Cerebrospinal Fluid / physiology; Cerebrospinal Fluid Pressure / physiology; Elastic Modulus; Equipment Design; Models, Biological; Posture / physiology; Rheology
• Language: english
• Publication type: Scientific paper - Original scientific paper
• Publication status: Published
• Peer review: Peer review
• Publication version: Published version
• Journal title: Collegium Antropologicum
• Numbering: vol. 35, no. S. 1, pp. 51-56
• p-ISSN: 0350-6134
• URN:NBN: urn:nbn:hr:105:047138
• Publication: 2011-01
• Document URL: https://hrcak.srce.hr/64040
• Type of resource: Text
• Access conditions: Open access
• Created on: 2024-03-28 11:59:26