Unraveling the biological mechanisms in Alzheimer's disease - lessons from genomics

Borovečki, Fran; Klepac, Nataša; Muck-Šeler, Dorotea; Hajnšek, Sanja; Mubrin, Zdenko; Pivac, Nela

doi:10.1016/j.pnpbp.2010.12.019

Scientific paper - Original scientific paper

Unraveling the biological mechanisms in Alzheimer's disease - lessons from genomics

Progress in Neuro-Psychopharmacology & Biological Psychiatry, 35 (2011), 2; 340-347. https://doi.org/10.1016/j.pnpbp.2010.12.019

Borovečki, Fran; Klepac, Nataša; Muck-Šeler, Dorotea; Hajnšek, Sanja; Mubrin, Zdenko; Pivac, Nela

Cite this document

APA 6th Edition

Borovečki, F., Klepac, N., Muck Šeler, D., Hajnšek, S., Mubrin, Z. & Pivac, N. (2011). Unraveling the biological mechanisms in Alzheimer's disease - lessons from genomics. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 35. (2), 340-347. doi: 10.1016/j.pnpbp.2010.12.019

MLA 8th Edition

Borovečki, Fran, et al. "Unraveling the biological mechanisms in Alzheimer's disease - lessons from genomics." Progress in Neuro-Psychopharmacology & Biological Psychiatry, vol. 35, no. 2, 2011, pp. 340-347. https://doi.org/10.1016/j.pnpbp.2010.12.019

Chicago 17th Edition

Borovečki, Fran, Nataša Klepac, Dorotea Muck Šeler, Sanja Hajnšek, Zdenko Mubrin and Nela Pivac. "Unraveling the biological mechanisms in Alzheimer's disease - lessons from genomics." Progress in Neuro-Psychopharmacology & Biological Psychiatry 35, no. 2 (2011): 340-347. https://doi.org/10.1016/j.pnpbp.2010.12.019

Harvard

Borovečki, F., et al. (2011) 'Unraveling the biological mechanisms in Alzheimer's disease - lessons from genomics', Progress in Neuro-Psychopharmacology & Biological Psychiatry, 35(2), pp. 340-347. doi: 10.1016/j.pnpbp.2010.12.019

Vancouver

Borovečki F, Klepac N, Muck Šeler D, Hajnšek S, Mubrin Z, Pivac N. Unraveling the biological mechanisms in Alzheimer's disease - lessons from genomics. Progress in Neuro-Psychopharmacology & Biological Psychiatry [Internet]. 2011 March 30 [cited 2024 April 11];35(2):340-347. doi: 10.1016/j.pnpbp.2010.12.019

IEEE

F. Borovečki, N. Klepac, D. Muck Šeler, S. Hajnšek, Z. Mubrin and N. Pivac, "Unraveling the biological mechanisms in Alzheimer's disease - lessons from genomics", Progress in Neuro-Psychopharmacology & Biological Psychiatry, vol. 35, no. 2, pp. 340-347, March 2011. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:983485. [Accessed: 11 April 2024]

Cite this item: https://urn.nsk.hr/urn:nbn:hr:105:983485

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Metadata

Title (english)	Unraveling the biological mechanisms in Alzheimer's disease - lessons from genomics
Author	Fran Borovečki
Author	Nataša Klepac
Author	Dorotea Muck-Šeler
Author	Sanja Hajnšek
Author	Zdenko Mubrin
Author	Nela Pivac
Author's institution	University of Zagreb School of Medicine
Scientific / art field, discipline and subdiscipline	BIOMEDICINE AND HEALTHCARE Clinical Medical Sciences
Abstract (english)	Alzheimer's disease (AD) is the most common form of dementia and the most common neurodegenerative disease, with a complex genetic background. Genome-wide association studies (GWAS) have yielded important new insights into genetic mechanisms of AD pathology. Current results unequivocally confirm apolipoprotein E (APOE) as a major genetic risk factor for development of late onset AD. Additional associations of more than twenty genes have also been identified and replicated in subsequent genetic studies. Despite the exciting new GWAS data which have emerged in the last few years, it has become clear that common variants within the genome cannot fully explain the underlying genetic risk for AD. Novel approaches such as genome-wide analysis of copy number variations (CNV) or low-frequency rare functional gene variants may provide additional insight into genetic basis of AD. In this review we summarize the findings of eighteen GWAS studies in AD performed to date, with an emphasis on potential future developments in the quest for genetic risk factors of AD.
Keywords (english)
Language	english
Publication type	Scientific paper - Original scientific paper
Publication status	Published
Peer review	Peer review
Publication version	Accepted version
Journal title	Progress in Neuro-Psychopharmacology & Biological Psychiatry
Numbering	vol. 35, no. 2, pp. 340-347
p-ISSN	0278-5846
DOI	https://doi.org/10.1016/j.pnpbp.2010.12.019
URN:NBN	urn:nbn:hr:105:983485
Publication	2011-03-30
Document URL	https://doi.org/10.1016/j.pnpbp.2010.12.019
Type of resource	Text
Access conditions	Open access
Terms of use
Created on	2024-03-28 12:02:13