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Scientific paper - Original scientific paper
Unraveling the biological mechanisms in Alzheimer's disease - lessons from genomics
Progress in Neuro-Psychopharmacology & Biological Psychiatry, 35 (2011), 2; 340-347. https://doi.org/10.1016/j.pnpbp.2010.12.019
Borovečki, Fran; Klepac, Nataša; Muck-Šeler, Dorotea; Hajnšek, Sanja; Mubrin, Zdenko; Pivac, Nela

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Borovečki, F., Klepac, N., Muck Šeler, D., Hajnšek, S., Mubrin, Z. & Pivac, N. (2011). Unraveling the biological mechanisms in Alzheimer's disease - lessons from genomics. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 35. (2), 340-347. doi: 10.1016/j.pnpbp.2010.12.019

Borovečki, Fran, et al. "Unraveling the biological mechanisms in Alzheimer's disease - lessons from genomics." Progress in Neuro-Psychopharmacology & Biological Psychiatry, vol. 35, no. 2, 2011, pp. 340-347. https://doi.org/10.1016/j.pnpbp.2010.12.019

Borovečki, Fran, Nataša Klepac, Dorotea Muck Šeler, Sanja Hajnšek, Zdenko Mubrin and Nela Pivac. "Unraveling the biological mechanisms in Alzheimer's disease - lessons from genomics." Progress in Neuro-Psychopharmacology & Biological Psychiatry 35, no. 2 (2011): 340-347. https://doi.org/10.1016/j.pnpbp.2010.12.019

Borovečki, F., et al. (2011) 'Unraveling the biological mechanisms in Alzheimer's disease - lessons from genomics', Progress in Neuro-Psychopharmacology & Biological Psychiatry, 35(2), pp. 340-347. doi: 10.1016/j.pnpbp.2010.12.019

Borovečki F, Klepac N, Muck Šeler D, Hajnšek S, Mubrin Z, Pivac N. Unraveling the biological mechanisms in Alzheimer's disease - lessons from genomics. Progress in Neuro-Psychopharmacology & Biological Psychiatry [Internet]. 2011 March 30 [cited 2024 December 23];35(2):340-347. doi: 10.1016/j.pnpbp.2010.12.019

F. Borovečki, N. Klepac, D. Muck Šeler, S. Hajnšek, Z. Mubrin and N. Pivac, "Unraveling the biological mechanisms in Alzheimer's disease - lessons from genomics", Progress in Neuro-Psychopharmacology & Biological Psychiatry, vol. 35, no. 2, pp. 340-347, March 2011. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:983485. [Accessed: 23 December 2024]

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Metadata
Title (english)Unraveling the biological mechanisms in Alzheimer's disease - lessons from genomics
AuthorFran Borovečki
AuthorNataša Klepac
AuthorDorotea Muck-Šeler
AuthorSanja Hajnšek
AuthorZdenko Mubrin
AuthorNela Pivac
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Alzheimer's disease (AD) is the most common form of dementia and the most common neurodegenerative disease, with a complex genetic background. Genome-wide association studies (GWAS) have yielded important new insights into genetic mechanisms of AD pathology. Current results unequivocally confirm apolipoprotein E (APOE) as a major genetic risk factor for development of late onset AD. Additional associations of more than twenty genes have also been identified and replicated in subsequent genetic studies. Despite the exciting new GWAS data which have emerged in the last few years, it has become clear that common variants within the genome cannot fully explain the underlying genetic risk for AD. Novel approaches such as genome-wide analysis of copy number variations (CNV) or low-frequency rare functional gene variants may provide additional insight into genetic basis of AD. In this review we summarize the findings of eighteen GWAS studies in AD performed to date, with an emphasis on potential future developments in the quest for genetic risk factors of AD.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleProgress in Neuro-Psychopharmacology & Biological Psychiatry
Numberingvol. 35, no. 2, pp. 340-347
p-ISSN0278-5846
DOIhttps://doi.org/10.1016/j.pnpbp.2010.12.019
URN:NBNurn:nbn:hr:105:983485
Publication2011-03-30
Document URLhttps://doi.org/10.1016/j.pnpbp.2010.12.019
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 12:02:13