Ekvivalent: Granulomatoza s poliangiitisom i lokaliziranim zahvaćanjem gornjega dišnoga sustava ‒ prikaz bolesnice

professional thesis

• Title (english): Equivalent: Granulomatosis with polyangiitis (GPA) limited to upper respiratory tract – a case report
• Author: Ivan Marković
• Mentor: Jadranka Morović-Vergles (mentor)
• Granter: University of Zagreb; School of Medicine; Zagreb
• Defense date and country: 2022-01-10, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Clinical Immunology

Abstract

Granulomatoza s poliangiitisom (Wegenerova granulomatoza) ubraja se u vaskulitise malih krvnih žila povezane s antineutrofilnim citoplazmatskim protutijelima. Najčešće su zahvaćeni gornji i donji dišni sustav te bubrezi. Obilježjan bolesti uključuju granulomatoznu upalu dišnog sustava i nekrotizirajući vaskulitis malih do srednje velikih krvnih žila. U većine je bolesnika pri postavljanju dijagnoze zahvaćeno više organskih sustava te mogu biti prisutni i opći simptomi, dok je u oko četvrtine bolesnika inicijalno prisutan lokalizirani oblik bolesti sa zahvaćanjem najčešće gornjega dišnog sustava ili pluća. U radu smo prikazali dvadesetjednogodišnju bolesnicu s kroničnim rinitisom, razvojem sedlaste deformacije nosa i subglotičnom stenozom traheje koja je hospitalizirana zbog inspiratornog stridora. Zbog respiratorne insuficijencije učinjena je hitna traheotomija. U bolesnice je dijagnosticirana granulomatoza s poliangiitisom ograničena na gornji dišni sustav. Liječenje glukokortikoidima i metotreksatom dovelo je do kliničkog poboljšanja.

Abstract (english)

Granulomatosis with polyangiitis (Wegener’s granulomatosis) is one of the anti-neutrophil cytoplasmic antibody-associated small vessel vasculitides. Upper and lower respiratory system and kidneys are most commonly affected. The disease is characterized by granulomatous inflammation of the respiratory tract and necrotizing vasculitis of small to medium-sized blood vessels. Most patients show involvement of more than one organ systems at the time of diagnosis, and constitutional symptoms may be present. In around a quarter of patients the disease is initially localised, with involvement of upper respiratory tract or lungs. We report a 21-year-old female patient with chronic rhinitis, saddle nose deformity and subglottic stenosis who presented with inspiratory stridor and impending respiratory failure. Initially, urgent tracheotomy was performed. The patient was diagnosed with granulomatosis with polyangiitis limited to upper respiratory tract. Treatment with glucocorticoids and methotrexate was followed by clinical improvement.

• Keywords: Granulomatoza s poliangiitisom – dijagnoza; komplikacije; imunologija; farmakoterapija; Laringostenoza – etiologija; komplikacije; Respiracijski zvukovi – etiologija; Traheotomija; Metotreksat – terapijska primjena; Imunosupresijski lijekovi – terapijska primjena; Glukokortikoidi – terapijska primjena; Nosne stečene deformacije – etiologija; Nosna sluznica – patologija
• Keywords (english): Granulomatosis with polyangiitis – diagnosis; complications; immunology; drug therapy; Laryngostenosis – etiology; complications; Respiratory sounds – etiology; Tracheotomy; Methotrexate – therapeutic use; Immunosuppressive agents – therapeutic use; Glucocorticoids – therapeutic use; Nose deformities; acquired – etiology; Nasal mucosa – pathology
• Language: croatian
• URN:NBN: urn:nbn:hr:105:378875
• Study programme: Title: Allergology and clinical immunology; Study programme type: university; Study level: postgraduate specialist; Academic / professional title: sveučilišni/a magistar/magistra alergologije i kliničke imunologije (sveučilišni/a magistar/magistra alergologije i kliničke imunologije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2024-04-05 11:32:35