Kirurško liječenje mukoepidermoidnog karcinom žlijezda slinovnica

master's thesis

• Title (english): Surgical treatment of mucoepidermoid carcinoma of the salivary glands
• Author: Luka Manojlović
• Mentor: Ivica Lukšić (mentor)
• Committee member: Mihajlo Virag (predsjednik povjerenstva)
• Committee member: Narandža Aljinović-Ratković (član povjerenstva)
• Committee member: Ivica Lukšić (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Maxillofacial Surgery and Dentistry); Zagreb
• Defense date and country: 2015-09-25, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Surgery

Abstract

Cilj ovog rada je bio utvrditi broj kirurški liječenih bolesnika s mukoepidermoidnim karcinomom žlijezda slinovnica u razdoblju od 25 godina, odrediti njihovu raspodjelu prema spolu, dobi bolesnika i lokalizaciji, te procijeniti uspješnost terapije.
Retrospektivnom analizom podataka utvrđeno je da je u Klinici za kirurgiju lica, čeljusti i usta KB Dubrava u razdoblju od 1990. do 2014. godine primarno kirurški liječeno 65 bolesnika s mukoepidermoidnim karcinomom žlijezda slinovnica, koji je bio nešto učestaliji kod muškaraca (52,3%) nego kod žena (47,7%). Srednja dob bolesnika je bila 46 godina, a 10,8% bolesnika bilo je dječje dobi.
Najčešća lokalizacija mukoepidermoidnog karcinoma bila je u parotidnoj žlijezdi (56,9%), a od malih žlijezda slinovnica najčešće su bile zahvaćene one na nepcu.
Bolesnici su najčešće bili liječeni isključivo kirurškom ekscizijom odnosno parotidektomijom, a kod uznapredovale bolesti i dodatnom disekcijom regionalnih limfnih čvorova na vratu.
Ukupno preživljenje je bilo 87,7%, što odgovara statističkim podacima iz recentne literature o preživljenju za mukoepidermoidne karcinome niskog i srednjeg stupnja malignosti.
Ovi podaci potvrđuju da je kirurška metoda optimalan izbor liječenja bolesnika s mukoepidermoidnim karcinomom žlijezda slinovnica.

Abstract (english)

The aim of this study was to determine the number of surgically treated patients with mucoepidermoid carcinoma of the salivary glands during a 25-year period, to analyze its distribution according to the patients’ gender, age and the localization of the tumor, and to evaluate the success of treatment.
A retrospective analysis of medical records showed that from 1990 to 2014 at the Department of Maxillofacial Surgery, University Hospital Dubrava 65 patients with mucoepidermoid carcinoma of the salivary glands were treated surgically, men (52,3%) slightly more often than woman (47,7%). The patients’ average age was 46 years, with 10.8% of patients of childhood age.
The most frequent localization of mucoepidermoid carcinoma was the parotid gland, with the palate being the most frequent localization of carcinoma of the minor salivary glands.
Patients were most frequently treated by surgical excision or parotidectomy, and additional dissection of the cervical lymph nodes was performed on cases with advanced disease.
The overall survival rate was 87,7%, which corresponds with statistical information obtained from literature concerning the survival rate for low- and intermediate-grade mucoepidermoid carcinoma.
These findings confirm that surgical treatment is the optimal choice in treating patients with mucoepidermoid carcinoma of the salivary glands.

• Keywords: mukoepidermoidni karcinom; žlijezde slinovnice; kirurško liječenje
• Keywords (english): mucoepidermoid carcinoma; salivary gland; surgical treatment
• Language: croatian
• URN:NBN: urn:nbn:hr:105:836548
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2016-11-23 13:42:09