Epigenetske promjene u shizofreniji, bipolarnom poremećaju i depresiji

master's thesis

• Title (english): Epigenetic changes in schizophrenia, bipolar disorder and depression
• Author: Tonći Kero
• Mentor: Ljiljana Šerman (mentor)
• Committee member: Dražen Begić (predsjednik povjerenstva)
• Committee member: Nataša Jovanov-Milošević (član povjerenstva)
• Committee member: Ljiljana Šerman (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Medical Biology); Zagreb
• Defense date and country: 2015-09-25, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Medical Microbiology

Abstract

U prvoj polovici dvadesetog stoljeća, razvojna biologija i genetika bile su odvojene discipline. Riječ epigenetika prvi put je upotrijebio C. Waddington kao jedan od moguće više spojnih neksusa genotipa i fenotipa. Epigenetika u svom fokusu ima regulaciju aktivnosti gena, za razliku od polja genetike koje se bavi anatomijom samih gena, odnosno slijedom dušičnih baza koje označavaju genetski kod, ali koja samostalno ne može objasniti sve biološke aspekte ljudskog razvoja. Regulacija aktivnosti gena odnosi se na načine na koje genetska informacija može biti suprimirana ili aktivirana u različitim razvojnim linijama stanica ili prenesena dalje na potomstvo. Prvo desetljeće 21. stoljeća obilježeno je velikim porastom interesa biomedicinskih istraživanja za polje epigenetike. U raznim istraživanjima pokazane su pozitivne korelacije između epigenetskih abnormalnosti i psihijatrijskih bolesti, a ovdje se specifično obrađuju depresija, shizofrenija i bipolarni poremećaj.

Abstract (english)

In the first half of the twentieth century, developmental biology and genetics were considered separate disciplines. Word epigenetics was first used by C. Waddington as a possible nexus between the genotype and phenotype. The focus of epigenetics is the regulation of gene activity, in contrast to the field of genetics, which deals with the anatomy of genes themselves, or the sequence of nitrogen-containing nucleobases that make the genetic code, but which cannot explain all biological aspects of human development on its own. Regulation of gene refers to the ways in which genetic information can be suppressed or activated in different evolutionary cell lineages or transferred further to an offspring. The first decade of the 21st century was marked by an increased interest of biomedical research in the field of epigenetics. Various studies have shown positive correlations between epigenetic abnormalities and psychiatric diseases, and here the focus is specifically on depression, schizophrenia and bipolar disorder.

• Keywords: razvojna biologija; epigenetika; genotip; fenotip; depresija; shizofrenija; bipolarni poremećaj
• Keywords (english): developmental biology; epigenetics; genotype; phenotype; depression; schizophrenia; bipolar disorder
• Language: croatian
• URN:NBN: urn:nbn:hr:105:359327
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2016-11-24 08:40:58