prikaz prve stranice dokumenta Examining the environmental risk factors of progressive-onset and relapsing-onset multiple sclerosis: recruitment challenges, potential bias, and statistical strategies
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Scientific paper - Original scientific paper
Examining the environmental risk factors of progressive-onset and relapsing-onset multiple sclerosis: recruitment challenges, potential bias, and statistical strategies
Journal of Neurology, 271 (2024), 1; 472-485. https://doi.org/10.1007/s00415-023-11980-z
(MSBase) Li, Ying; Saul, Alice; Taylor, Bruce; Ponsonby, Anne-Louise; Simpson-Yap, Steve; Blizzard, Leigh; Broadley, Simon; Lechner-Scott, Jeannette; Lucas, Robyn; Dear, Keith; Ponsonby, Anne-Louise; Dwyer, Terry; van der Mei, Ingrid; Blizzard, Leigh; Simpson-Yap, Steve; Taylor, Bruce; Broadley, Simon; Kilpatrick, Trevor; Williams, David; Lechner-Scott, Jeanette; Shaw, Cameron; Chapman, Caron; Coulthard, Alan; Pender, Michael; Valery, Patricia; Karabudak, Rana; Patti, Francesco; Eichau, Sara; Onofrj, Marco; Ozakbas, Serkan; Horakova, Dana; Kubala Havrdova, Eva; Grand’Maison, Francois; Alroughani, Raed; Gerlach, Oliver; Amato, Maria Pia; Altintas, Ayse; Girard, Marc; Duquette, Pierre; Blanco, Yolanda; Ramo-Tello, Cristina; Laureys, Guy; Kalincik, Tomas; Khoury, Samia J.; Shaygannejad, Vahid; Etemadifar, Masoud; Singhal, Bhim; Mrabet, Saloua; Foschi, Matteo; Habek, Mario; John, Nevin; Hughes, Stella; McCombe, Pamela; Ampapa, Radek; van der Walt, Anneke; Butzkueven, Helmut; de Gans, Koen; McGuigan, Chris; Oreja-Guevara, Celia; Sa, Maria Jose; Petersen, Thor; Al-Harbi, Talal; Sempere, Angel Perez; Van Wijmeersch, Bart; Grigoriadis, Nikolaos; Prevost, Julie; Gray, Orla; Castillo-Triviño, Tamara; Macdonell, Richard; Lugaresi, Alessandra; Sajedi, Seyed Aidin; van der Mei, Ingrid More authors...

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Li, Y., Saul, A., Taylor, B., Ponsonby, A. L., Simpson Yap, S., Blizzard, L. ... van der Mei, I. (2024). Examining the environmental risk factors of progressive-onset and relapsing-onset multiple sclerosis: recruitment challenges, potential bias, and statistical strategies. Journal of Neurology, 271. (1), 472-485. doi: 10.1007/s00415-023-11980-z

Li, Ying, et al. "Examining the environmental risk factors of progressive-onset and relapsing-onset multiple sclerosis: recruitment challenges, potential bias, and statistical strategies." Journal of Neurology, vol. 271, no. 1, 2024, pp. 472-485. https://doi.org/10.1007/s00415-023-11980-z

Li, Ying, Alice Saul, Bruce Taylor, Anne Louise Ponsonby, Steve Simpson Yap, Leigh Blizzard, Simon Broadley, et al. "Examining the environmental risk factors of progressive-onset and relapsing-onset multiple sclerosis: recruitment challenges, potential bias, and statistical strategies." Journal of Neurology 271, no. 1 (2024): 472-485. https://doi.org/10.1007/s00415-023-11980-z

Li, Y., et al. (2024) 'Examining the environmental risk factors of progressive-onset and relapsing-onset multiple sclerosis: recruitment challenges, potential bias, and statistical strategies', Journal of Neurology, 271(1), pp. 472-485. doi: 10.1007/s00415-023-11980-z

Li Y, Saul A, Taylor B, Ponsonby AL, Simpson Yap S, Blizzard L, and sur.. Examining the environmental risk factors of progressive-onset and relapsing-onset multiple sclerosis: recruitment challenges, potential bias, and statistical strategies. Journal of Neurology [Internet]. 2024 January [cited 2025 March 31];271(1):472-485. doi: 10.1007/s00415-023-11980-z

Y. Li, et al., "Examining the environmental risk factors of progressive-onset and relapsing-onset multiple sclerosis: recruitment challenges, potential bias, and statistical strategies", Journal of Neurology, vol. 271, no. 1, pp. 472-485, January 2024. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:366542. [Accessed: 31 March 2025]

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Metadata
Title (english)Examining the environmental risk factors of progressive-onset and relapsing-onset multiple sclerosis: recruitment challenges, potential bias, and statistical strategies
AuthorYing Li
AuthorAlice Saul
AuthorBruce Taylor
AuthorAnne-Louise Ponsonby
AuthorSteve Simpson-Yap
AuthorLeigh Blizzard
AuthorSimon Broadley
AuthorJeannette Lechner-Scott
AuthorRobyn Lucas
AuthorKeith Dear
AuthorAnne-Louise Ponsonby
AuthorTerry Dwyer
AuthorIngrid van der Mei
AuthorLeigh Blizzard
AuthorSteve Simpson-Yap
AuthorBruce Taylor
AuthorSimon Broadley
AuthorTrevor Kilpatrick
AuthorDavid Williams
AuthorJeanette Lechner-Scott
AuthorCameron Shaw
AuthorCaron Chapman
AuthorAlan Coulthard
AuthorMichael Pender
AuthorPatricia Valery
AuthorRana Karabudak
AuthorFrancesco Patti
AuthorSara Eichau
AuthorMarco Onofrj
AuthorSerkan Ozakbas
AuthorDana Horakova
AuthorEva Kubala Havrdova
AuthorFrancois Grand’Maison
AuthorRaed Alroughani
AuthorOliver Gerlach
AuthorMaria Pia Amato
AuthorAyse Altintas
AuthorMarc Girard
AuthorPierre Duquette
AuthorYolanda Blanco
AuthorCristina Ramo-Tello
AuthorGuy Laureys
AuthorTomas Kalincik
AuthorSamia J. Khoury
AuthorVahid Shaygannejad
AuthorMasoud Etemadifar
AuthorBhim Singhal
AuthorSaloua Mrabet
AuthorMatteo Foschi
AuthorMario Habek
AuthorNevin John
AuthorStella Hughes
AuthorPamela McCombe
AuthorRadek Ampapa
AuthorAnneke van der Walt
AuthorHelmut Butzkueven
AuthorKoen de Gans
AuthorChris McGuigan
AuthorCelia Oreja-Guevara
AuthorMaria Jose Sa
AuthorThor Petersen
AuthorTalal Al-Harbi
AuthorAngel Perez Sempere
AuthorBart Van Wijmeersch
AuthorNikolaos Grigoriadis
AuthorJulie Prevost
AuthorOrla Gray
AuthorTamara Castillo-Triviño
AuthorRichard Macdonell
AuthorAlessandra Lugaresi
AuthorSeyed Aidin Sajedi
AuthorIngrid van der Mei
CollaborationMSBase
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Neurology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Neurology
Abstract (english)
It is unknown whether the currently known risk factors of multiple sclerosis reflect the etiology of progressive-onset multiple sclerosis (POMS) as observational studies rarely included analysis by type of onset. We designed a case–control study to examine associations between environmental factors and POMS and compared effect sizes to relapse-onset MS (ROMS), which will offer insights into the etiology of POMS and potentially contribute to prevention and intervention practice. This study utilizes data from the Primary Progressive Multiple Sclerosis (PPMS) Study and the Australian Multi-center Study of Environment and Immune Function (the AusImmune Study). This report outlines the conduct of the PPMS Study, whether the POMS sample is representative, and the planned analysis methods. The study includes 155 POMS, 204 ROMS, and 558 controls. The distributions of the POMS were largely similar to Australian POMS patients in the MSBase Study, with 54.8% female, 85.8% POMS born before 1970, mean age of onset of 41.44 ± 8.38 years old, and 67.1% living between 28.9 and 39.4° S. The POMS were representative of the Australian POMS population. There are some differences between POMS and ROMS/controls (mean age at interview: POMS 55 years vs. controls 40 years; sex: POMS 53% female vs. controls 78% female; location of residence: 14.3% of POMS at a latitude ≤ 28.9°S vs. 32.8% in controls), which will be taken into account in the analysis. We discuss the methodological issues considered in the study design, including prevalence-incidence bias, cohort effects, interview bias and recall bias, and present strategies to account for it. Associations between exposures of interest and POMS/ROMS will be presented in subsequent publications.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleJournal of Neurology
Numberingvol. 271, no. 1, pp. 472-485
p-ISSN0340-5354
e-ISSN1432-1459
DOIhttps://doi.org/10.1007/s00415-023-11980-z
URN:NBNurn:nbn:hr:105:366542
Publication2024-01
Document URLhttps://link.springer.com/10.1007/s00415-023-11980-z
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2024-05-20 08:25:00