prikaz prve stranice dokumenta Bloodstream Infections by AmpC-Producing Enterobacterales: Risk Factors and Therapeutic Outcome
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Scientific paper - Original scientific paper
Bloodstream Infections by AmpC-Producing Enterobacterales: Risk Factors and Therapeutic Outcome
Pathogens, 12 (2023), 9; 1125. https://doi.org/10.3390/pathogens12091125
Pospišil, Mladen; Car, Haris; Elveđi-Gašparović, Vesna; Beader, Nataša; Herljević, Zoran; Bedenić, Branka

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Pospišil, M., Car, H., Elveđi Gašparović, V., Beader, N., Herljević, Z. & Bedenić, B. (2023). Bloodstream Infections by AmpC-Producing Enterobacterales: Risk Factors and Therapeutic Outcome. Pathogens, 12. (9). doi: 10.3390/pathogens12091125

Pospišil, Mladen, et al. "Bloodstream Infections by AmpC-Producing Enterobacterales: Risk Factors and Therapeutic Outcome." Pathogens, vol. 12, no. 9, 2023. https://doi.org/10.3390/pathogens12091125

Pospišil, Mladen, Haris Car, Vesna Elveđi Gašparović, Nataša Beader, Zoran Herljević and Branka Bedenić. "Bloodstream Infections by AmpC-Producing Enterobacterales: Risk Factors and Therapeutic Outcome." Pathogens 12, no. 9 (2023). https://doi.org/10.3390/pathogens12091125

Pospišil, M., et al. (2023) 'Bloodstream Infections by AmpC-Producing Enterobacterales: Risk Factors and Therapeutic Outcome', Pathogens, 12(9). doi: 10.3390/pathogens12091125

Pospišil M, Car H, Elveđi Gašparović V, Beader N, Herljević Z, Bedenić B. Bloodstream Infections by AmpC-Producing Enterobacterales: Risk Factors and Therapeutic Outcome. Pathogens [Internet]. 2023 September 03 [cited 2024 December 30];12(9). doi: 10.3390/pathogens12091125

M. Pospišil, H. Car, V. Elveđi Gašparović, N. Beader, Z. Herljević and B. Bedenić, "Bloodstream Infections by AmpC-Producing Enterobacterales: Risk Factors and Therapeutic Outcome", Pathogens, vol. 12, no. 9, September 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:515558. [Accessed: 30 December 2024]

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Metadata
Title (english)Bloodstream Infections by AmpC-Producing Enterobacterales: Risk Factors and Therapeutic Outcome
AuthorMladen Pospišil
AuthorHaris Car
AuthorVesna Elveđi-Gašparović
AuthorNataša Beader
AuthorZoran Herljević
AuthorBranka Bedenić
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Medical Microbiology and Parasitology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Gynecology and Obstetrics
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Medical Microbiology
Abstract (english)
Bloodstream infections associated with AmpC-producing Enterobacterales are severe medical conditions which, without prompt and effective treatment, may have dire ramifications. This study aimed to assess whether certain comorbidities and previous surgical procedures coincide with resistance determinants of AmpC-producing Enterobacterales associated with bloodstream infections. Antibiotic resistance patterns and therapy outcome were also determined. The patients’ data obtained revealed that the prevalence of recent surgical procedures, solid organ tumors, metabolic diseases, kidney and liver failure, and hematological malignancies do not differ between resistant and susceptible isolates of AmpC-producing Enterobacterales. Furthermore, no difference was reported in mortality rates. Regarding antibiotic resistance, 34.52% of isolates were confirmed to be resistant (AmpC hyperproduction, ESBL, or carbapenemase). More than one in five AmpC hyperproducers were reported amid Providencia spp., K. aerogenes, E. cloacae, and C. freundii. strains. Carbapenemases were mostly noted in Providencia spp. followed by M. morganii and K. aerogenes strains. Serratia marcescens had the highest proportion of ESBLsof ESBLs. Resistance to expanded-spectrum cephalosporins of Providencia spp. and K. aerogenes strains exceeded 50%, and resistance to meropenem over 10% was observed only in C. freundii strains. Enterobacterales’ ever-growing resistance to antibiotics is becoming quite a challenge for clinicians and new treatment options are required.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titlePathogens
Numberingvol. 12, no. 9, 1125
e-ISSN2076-0817
DOIhttps://doi.org/10.3390/pathogens12091125
URN:NBNurn:nbn:hr:105:515558
Publication2023-09-03
Document URLhttps://www.mdpi.com/2076-0817/12/9/1125
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2024-05-20 08:30:17