prikaz prve stranice dokumenta Low Valine Serum Levels Predict Increased 1-Year Mortality in Acute Heart Failure Patients
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Scientific paper - Original scientific paper
Low Valine Serum Levels Predict Increased 1-Year Mortality in Acute Heart Failure Patients
Biomolecules, 13 (2023), 9; 1323. https://doi.org/10.3390/biom13091323
Klobučar, Iva; Vidović, Luka; Arih, Ilona; Lechleitner, Margarete; Pregartner, Gudrun; Berghold, Andrea; Habisch, Hansjörg; Madl, Tobias; Frank, Saša; Degoricija, Vesna

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Klobučar, I., Vidović, L., Arih, I., Lechleitner, M., Pregartner, G., Berghold, A. ... Degoricija, V. (2023). Low Valine Serum Levels Predict Increased 1-Year Mortality in Acute Heart Failure Patients. Biomolecules, 13. (9). doi: 10.3390/biom13091323

Klobučar, Iva, et al. "Low Valine Serum Levels Predict Increased 1-Year Mortality in Acute Heart Failure Patients." Biomolecules, vol. 13, no. 9, 2023. https://doi.org/10.3390/biom13091323

Klobučar, Iva, Luka Vidović, Ilona Arih, Margarete Lechleitner, Gudrun Pregartner, Andrea Berghold, Hansjörg Habisch, Tobias Madl, Saša Frank and Vesna Degoricija. "Low Valine Serum Levels Predict Increased 1-Year Mortality in Acute Heart Failure Patients." Biomolecules 13, no. 9 (2023). https://doi.org/10.3390/biom13091323

Klobučar, I., et al. (2023) 'Low Valine Serum Levels Predict Increased 1-Year Mortality in Acute Heart Failure Patients', Biomolecules, 13(9). doi: 10.3390/biom13091323

Klobučar I, Vidović L, Arih I, Lechleitner M, Pregartner G, Berghold A, and sur.. Low Valine Serum Levels Predict Increased 1-Year Mortality in Acute Heart Failure Patients. Biomolecules [Internet]. 2023 August 29 [cited 2024 September 11];13(9). doi: 10.3390/biom13091323

I. Klobučar, et al., "Low Valine Serum Levels Predict Increased 1-Year Mortality in Acute Heart Failure Patients", Biomolecules, vol. 13, no. 9, August 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:305544. [Accessed: 11 September 2024]

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Metadata
Title (english)Low Valine Serum Levels Predict Increased 1-Year Mortality in Acute Heart Failure Patients
AuthorIva Klobučar
AuthorLuka Vidović
AuthorIlona Arih
AuthorMargarete Lechleitner
AuthorGudrun Pregartner
AuthorAndrea Berghold
AuthorHansjörg Habisch
AuthorTobias Madl
AuthorSaša Frank
AuthorVesna Degoricija
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Considering the relationship between disease severity and the extent of metabolic derangement in heart failure, we hypothesized that the serum levels of metabolites may have prognostic value for 1-year mortality in acute heart failure (AHF). The AHF study was a prospective, observational study enrolling consecutive patients hospitalized due to AHF. Metabolites were measured in serum collected at admission using NMR spectroscopy. Out of 315 AHF patients, 118 (37.5%) died within 1 year after hospitalization for AHF. The serum levels of 8 out of 49 identified metabolites were significantly different between patients who were alive and those who died within 1 year after hospitalization for AHF. Of these, only valine was significantly associated with 1-year mortality (hazard ratio 0.73 per 1 standard deviation increase, 95% confidence interval: 0.59–0.90, p = 0.003) in the multivariable Cox regression analyses. Kaplan–Maier analysis showed significantly higher survival rates in AHF patients with valine levels above the median (>279.2 µmol/L) compared to those with valine levels ≤ 279.2 µmol/L. In a receiver operating characteristics curve analysis, valine was able to discriminate between the two groups with an area under the curve of 0.65 (95% CI 0.59–0.72). We conclude that valine serum levels might be of prognostic value in AHF.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleBiomolecules
Numberingvol. 13, no. 9, 1323
e-ISSN2218-273X
DOIhttps://doi.org/10.3390/biom13091323
URN:NBNurn:nbn:hr:105:305544
Publication2023-08-29
Document URLhttps://www.mdpi.com/2218-273X/13/9/1323
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2024-05-21 10:31:59