Procjena disfunkcije mokraćnog mjehura kod osoba oboljelih od multiple skleroze

master's thesis

• Title (english): Assessment of bladder dysfunction in multiple sclerosis patients
• Author: Sara Grlić
• Mentor: Tereza Gabelić (mentor)
• Committee member: Dubravko Jalšovec (predsjednik povjerenstva)
• Committee member: Mario Habek (član povjerenstva)
• Committee member: Barbara Barun (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; Zagreb
• Defense date and country: 2024-12-07, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Neurology

Abstract

Multipla skleroza autoimuna je bolest s kroničnim progresivnim tijekom. Imunosni sustav u bolesti oštećuje mijelinsku ovojnicu živaca, što dovodi do oslabljenoga aksonskog provođenja, koje se manifestira neurološkim ispadima ovisno o mjestu lezije. Kako je mokrenje regulirano iz više centara koji se nalaze na različitim mjestima u živčanome sustavu, lezije na bilo kojoj od tih lokacija mogu dovesti do urinarnih smetnji. Kod 42 ispitanika učinjen je neurološki status s određivanjem EDSS-a i Urinary FS-a, snimljen je SSEP n. medianusa i tibialisa te su svi ispitanici ispunili ICIQ ocjenske ljestvice kvalitete života i prekomjerno aktivnoga mjehura. Za analizu su uzeti nalazi posljednjega dostupnog MR-a moždanoga debla i kralježnične moždine koji su učinjeni u sklopu rutinske obrade. Cilj istraživanja bilo je utvrđivanje povezanosti rezultata neurološkoga statusa, neurofiziološke i neuroradiološke obrade s ICIQ upitnicima. Rezultati istraživanja pokazali su statistički značajnu povezanost ICIQ upitnika s kliničkim vrijednostima EDSS-a i Urinary FS-a s kao i s vrijednostima P40 vala u SSEP n. tibialisa. Još jednom je potvrđena korelacija između onesposobljenosti u neurološkome statusu i vrijednostima SSEP n. tibialisa. Multimodalnom obradom bolesnika i specijaliziranim upitnicima možemo objektivizirati probleme s mokraćnim sustavom, koji često prate bolesnike s MS-om i narušavaju im kvalitetu života, te im omogućiti rano liječenje.

Abstract (english)

Multiple sclerosis is an autoimmune disease with chronic progressive course. The immune system in the disease damages the myelin lining of the nerves, leading to impaired axone conduction, which is manifested by neurological outbursts depending on the location of the lesion. As urination is regulated from multiple centers located in different locations in the nervous system, lesions at any of these locations can lead to urinary disturbances. In 42 subjects, neurological status was performed with determination of EDSS and urinary FS, SSEP n. medianus and tibialis were recorded, and all subjects fulfill ICIQ quality of life and overactive bladder rating scale. The last available brain and spinal cord MRI recorded as part of routine work-up was analysed. The aim of the study was to determine the correlation of neurological status, neurophysiological and neuroradiological work-up with the results of the ICIQ questionnaires. The results of the study showed a statistically significant association of the ICIQ questionnaire with clinical parameters EDSS and urinary FS as well as with P40 wave values in SSEP n. tibialis. The correlation between neurological disability and SSEP n. tibialis values was once again confirmed. Multimodal evaluation of patients and specialized questionnaires can objectify problems with the urinary system that often accompany MS patients and greatly impair their quality of life, allowing them to receive early treatment.

• Keywords: multipla skleroza; urinarna disfunkcija; somatosenzorni evocirani potencijali; ICIQ upitnici
• Keywords (english): multiple sclerosis; urinary dysfunction; somatosensory evoked potentials; ICIQ questionnaires
• Language: croatian
• URN:NBN: urn:nbn:hr:105:354568
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2024-06-13 17:58:06