Uloga koncentracije kortizona u slini i značajki slušnih evociranih potencijala moždanog debla u procjeni rizika od ranog profesionalnog oštećenja sluha bukom

doctoral thesis

• Title (english): The Role of Salivary Cortisone Concentration and Auditory Brainstem Response Characteristics in Assessment of the Early Occupational Noise-induced Hearing Loss Risk
• Author: Roko Žaja
• Mentor: Mihael Ries (mentor)
• Mentor: Milan Milošević (komentor)
• Committee member: Jakov Ajduk (predsjednik povjerenstva)
• Committee member: Maja Cigrovski Berković (član povjerenstva)
• Committee member: Jadranka Mustajbegović (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; Zagreb
• Defense date and country: 2024-05-27, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Otorhinolaryngology
• Universal decimal classification (UDC): 616 - Pathology. Clinical medicine

Abstract

Procjena rizika od ranoga profesionalnog oštećenja sluha osnova je zdravstvenog nadzora osoba koje rade u buci. Kako rano oštećenje sluha nije definirano dijagnostičkim kriterijima, nove neinvazivne metode za procjenu rizika i dijagnostiku kohlearne sinaptopatije predmet su aktualnih istraživanja. Cilj ovoga istraživanja bio je utvrditi povezanost ranoga oštećenja sluha s koncentracijom kortizona u slini i s omjerom amplituda prvoga i petoga vala evociranih slušnih potencijala moždanoga debla. Sudionici su bili radnici, koji su bili izloženi buci ekvivalentne razine intenziteta ≥ 85 dB(A) na mjestu rada 1 – 2 godine (N = 50), te studenti (N = 54) kao kontrolni sudionici. Tekućinskom kromatografijom visoke djelotvornosti utvrđena je značajno veća koncentracija kortizona u slini u izloženih sudionika u odnosu na kontrolne, te pozitivna korelacija između rizika od oštećenja sluha bukom i kortizona u slini. Ispitivanjem slušnih potencijala moždanoga debla evociranih klikom razine intenziteta 80 ili 90 dB, nije nađena korelacija između rizika od ranoga oštećenja sluha bukom i omjera amplituda prvoga i petoga vala. Rizik od ranoga profesionalnog oštećenja sluha moguće je djelomično procijeniti pomoću amplitude prvoga vala slušnih potencijala moždanoga debla evociranih klikom razine intenziteta 80 dB, koncentracije kortizona u slini, dobi i spola u mladih odraslih osoba.

Abstract (english)

Assessment of the early occupational noise-induced hearing loss risk is fundamental for health surveillance of people who work in noise. As early hearing loss is not well-defined diagnosis, novel non-invasive diagnostic methods are subjects of the current studies of the cochlear synaptopathy. The aim of this research was to determine the correlation between early hearing loss and: salivary cortisone level and the amplitude ratio of the first and fifth wave of evoked auditory brainstem response. The participants were workers, who were exposed to occupational noise ≥ 85 dB(A) for 1 – 2 years (N = 50), and students (N = 54) as controls. High-performance liquid chromatography revealed a significantly higher salivary cortisone level in exposed participants compared to the controls, and a positive correlation between the risk and salivary cortisone level. By examining auditory brainstem response evoked by a click at 80 or 90 dB, no correlation was found between the risk and the amplitude ratio of the first and fifth wave. Early occupational noise-induced hearing loss risk can be partially predicted by salivary cortisone level, amplitude of the first wave of auditory brainstem response evoked by a click at 80 dB, age, and sex in young adults.

• Keywords: Mlada odrasla osoba; Kortizon; Gubitak sluha uzrokovan bukom; Buka; radno okruženje; Evocirani potencijali; slušni; moždano deblo; Kromatografija; visokotlačna tekućina; Gubitak sluha; skriven; Studenti
• Keywords (english): Young Adult; Cortisone; Hearing Loss; Noise-Induced; Noise; Occupational; Evoked Potentials; Auditory; Brain Stem; Chromatography; High Pressure Liquid; Hearing Loss; Hidden; Students
• Language: croatian
• URN:NBN: urn:nbn:hr:105:283829
• Study programme: Title: Biomedicine and Health Sciences; Study programme type: university; Study level: postgraduate; Academic / professional title: doktor/doktorica znanosti, područje biomedicine i zdravstvo (doktor/doktorica znanosti, područje biomedicine i zdravstvo)
• Type of resource: Text
• Extent: 85 str.
• File origin: Born digital
• Access conditions: Open access
• Created on: 2024-06-24 09:25:59