Povezanost kolina i pojavnoga difuzijskoga koeficijenta dobivenih analizom multiparametrijske magnetske rezonancije s receptorom osjetljivim na kalcij u karcinomu dojke

doctoral thesis

• Title (english): Correlation between Cholin Peak and apparent diffusion coefficient at multiparametric magnetic resonance and Calcium sensing receptor expression in breast cancer
• Author: Iva Bušić Pavlek
• Mentor: Maja Prutki (mentor)
• Mentor: Zlatko Marušić (komentor)
• Committee member: Gordana Ivanac (predsjednik povjerenstva)
• Committee member: Anita Škrtić (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; Zagreb
• Defense date and country: 2024-06-03, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Radiology
• Universal decimal classification (UDC): 616 - Pathology. Clinical medicine

Abstract

Svrha rada: Svrha rada je bila istražiti povezanost između razine kolina, difuzijskog koeficijenta i razine CaSR u lezijama invazivnog karcinoma dojke putem MR dojki.
Metode: Uključeno je 79 pacijentica s NST karcinomom dojke te analizira morfološke i kinetičke karakteristike karcinoma. Postoperativno su preparati podvrgnuti imunohistokemijskoj analizi za razinu CaSR.
Rezultati: Rezultati su pokazali značajnu pozitivnu korelaciju CaSR s promjerom tumora, izražajnošću HER2, statusom limfnih čvorova i metastazama te negativnu korelaciju s izražajnošću ER receptora. Također, otkrivena je značajna pozitivna povezanost između CaSR i proliferacijskog indeksa Ki67. Iako nije potvrđena povezanost između kolina, CaSR i difuzijskog koeficijenta, postoji trend pozitivne povezanosti.
Zaključak: Ovi nalazi impliciraju da CaSR može biti važan prognostički čimbenik i pokazatelj malignog potencijala karcinoma dojke. Daljnja istraživanja mogla bi dodatno razjasniti ovu povezanost, što bi moglo poboljšati dijagnostiku i upravljanje karcinomom dojke.

Abstract (english)

Objective: The study aimed to investigate the correlation between choline level, diffusion coefficient, and CaSR level in lesions of invasive breast carcinoma using breast MR imaging. Methods: Seventy-nine patients with NST breast carcinoma were included, analyzing the morphological and kinetic characteristics of the carcinomas. Postoperatively, specimens underwent immunohistochemical analysis for CaSR level.
Results: The results showed a significant positive correlation of CaSR with tumor diameter, HER2 expression, lymph node status, and metastases, and a negative correlation with ER receptor expression. A significant positive association between CaSR and Ki67 proliferation index was also discovered. Although the correlation between choline, CaSR, and diffusion coefficient was not confirmed, there was a positive correlation trend.
Conclusion: These findings suggest that CaSR may be an important prognostic factor and indicator of breast carcinoma's malignant potential. Further research could clarify this association, potentially improving breast cancer diagnosis and management.

• Keywords: Ki-67 antigen; Neoplazme dojke; Karcinom; Kolin; Proliferacija stanica; Limfni čvorovic
• Keywords (english): Ki-67 Antigen; Breast Neoplasms; Carcinoma; Choline; Cell Proliferation; Lymph Nodes
• Language: croatian
• URN:NBN: urn:nbn:hr:105:723048
• Study programme: Title: Biomedicine and Health Sciences; Study programme type: university; Study level: postgraduate; Academic / professional title: doktor/doktorica znanosti, područje biomedicine i zdravstvo (doktor/doktorica znanosti, područje biomedicine i zdravstvo)
• Type of resource: Text
• Extent: 78 str.
• File origin: Born digital
• Access conditions: Open access
• Created on: 2024-06-25 11:49:17