Utjecaj opće anestezije na mozak u razvoju

master's thesis

• Title (english): The effect of general anesthesia on a developing brain
• Author: Adriana Adamović
• Mentor: Vilena Vrbanović Mijatović (mentor)
• Committee member: Daniela Bandić Pavlović (predsjednik povjerenstva)
• Committee member: Dinko Tonković (član povjerenstva)
• Committee member: Vilena Vrbanović Mijatović (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Anaesthesiology, Resuscitation and Intensive Care in Surgical Specialities); Zagreb
• Defense date and country: 2024-07-12, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Anesthesiology and Reanimatology

Abstract

Opća anestezija sigurna je rutinska metoda koja se danas često primjenjuje u djece. Uvod u anesteziju postiže se intravenskim ili inhalacijskim anesteticima. Najčešće primjenjivani intravenski anestetici su propofol, etomidat, tiopental i ketamin, a inhalacijski dušikov oksidul i sevofluran. Djelovanje anestetika na mozak uključuje više mehanizama, a najvažniji od njih je modulacija djelovanja ekscitacijskih i inhibicijskih neurotransmitera. Mnogo je istraživanja provedeno na životinjama koja pokazuju da primjena anestetika u mladunčadi dovodi do kasnijih poremećaja učenja i pamćenja te slabije prostorne memorije. Klinička su istraživanja također pokazala da anestetici imaju utjecaj na slabiji motorički i kognitivni razvoj u kasnijoj dobi djeteta. Anestezijom kraćeg trajanja, manjom dozom lijekova te njihovom kombiniranom primjenom može se smanjiti štetnost utjecaja anestetika na mozak u razvoju.

Abstract (english)

General anesthesia is a standard and safe procedure frequently utilized in pediatric practice today. Induction of anesthesia is achieved with intravenous or inhalation anesthetics. The most commonly used intravenous anesthetics are propofol, etomidate, thiopental and ketamine, while the most frequently used inhalation anesthetics are nitrous oxide and sevoflurane. The effects of anesthetics on the brain involve multiple mechanisms, the most important of which is the modulation of excitatory and inhibitory neurotransmitter activity. Numerous studies conducted on animals have shown that the administration of anesthetics in young animals leads to subsequent learning and memory disorders, as well as impaired spatial memory. Clinical studies have also demonstrated that anesthetics can impact poorer motor and cognitive development later in childhood. Shorter-duration anesthesia, lower drug doses, and their combined use can reduce the harmful effects of anesthetics on the developing brain.

• Keywords: opća anestezija; intravenski anestetici; inhalacijski anestetici; mozak u razvoju; neurotoksičnost
• Keywords (english): general anesthesia; intravenous anesthetics; inhalation anesthetics; developing brain; neurotoxicity
• Language: croatian
• URN:NBN: urn:nbn:hr:105:414356
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2024-06-26 13:43:10