Značaj gestacijskog dijabetesa u prevenciji metaboličkog sindroma

master's thesis

• Title (english): The importance of gestational diabetes in the prevention of metabolic syndrome
• Author: Tin Gabrić
• Mentor: Josip Juras (mentor)
• Committee member: Vito Starčević (predsjednik povjerenstva)
• Committee member: Dinka Pavičić Baldani (član povjerenstva)
• Committee member: Josip Juras (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Gynecology and Obstetrics); Zagreb
• Defense date and country: 2024-07-12, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Gynecology and Obstetrics

Abstract

Gestacijski dijabetes melitus (GDM) najčešći je uzrok hiperglikemije u trudnoći, stanja čija incidencija raste zadnjih godina zajedno sa pretilosti, šećernim bolestima i bolestima kardiovaskularnog sustava. GDM je bolest koja nosi rizik od kasnijih komplikacija zdravlja i majke (u vidu razvoja pretilosti, šećerne bolesti, hipertenzije i drugih kardiovaskularnih tegoba) i djeteta (poremećaji razvoja neurološkog, kardiovaskularnog i respiratornog sustava, sporiji rast, veća učestalost pretilosti). Nagađa se da anamneza GDM-a može služiti kao prediktivni faktor za kasniji razvoj metaboličkog sindroma (MetS) u žena. Zadnjih deset godina nekolicina dugotrajnih studija izvedena je sa svrhom potvrde te hipoteze. Zaključci studija nalažu da postoji statistički značajna povezanost između GDM-a i MetS-a, uz izraženu značajnost drugih čimbenika prije trudnoće poput abdominalne pretilosti te čimbenika tijekom trudnoće poput niske razine adiponektina u plazmi. Druga istraživanja na temu povezanosti GDM-a i MetS-a predlažu načine smanjivanja rizika od razvoja kasnijih komplikacija, poput terapije nadomještaja vitamina D, cinka i kalcija uz držanje režima „mediteranske“ prehrane. Od velike važnosti za suzbijanje posljedica GDM-om opterećene trudnoće jest dogovaranje učestalijih kontrolnih pregleda i pružanje korisnih i stalnih savjeta ženama s rizikom.

Abstract (english)

Gestational diabetes mellitus (GDM) is the most common cause of hyperglycemia in pregnancy, a condition with rising incidence in recent years alongside obesity, diabetes, and cardiovascular disease. GDM carries the risk of later health complications for both the mother (in terms of developing obesity, diabetes, hypertension, and other cardiovascular issues) and the child (disorders of neurological, cardiovascular, and respiratory system development, slower growth, higher risk of obesity later in life). It is speculated that a history of GDM may serve as a risk factor for the later development of metabolic syndrome (MetS) in women. Over the past ten years, several long-term studies have been conducted with the aim of confirming this hypothesis. The conclusions of the studies indicate that there is a statistically significant association between GDM and MetS, with a notable predictive significance of other factors: those before pregnancy such as abdominal obesity and those during pregnancy such as low plasma adiponectin levels. Other research on the topic of the association between GDM and MetS suggests ways to reduce the risk of developing later complications, such as vitamin D, zinc, and calcium co-suplementation along with adhering to a "Mediterranean" diet. It is of great importance to mitigate the consequences of a pregnancy burdened by GDM by scheduling more frequent check-ups and providing useful and ongoing advice to women at risk.

• Keywords: gestacijski dijabetes melitus; metabolički sindrom; abdominalna pretilost; inzulinska rezistencija; adipokini
• Keywords (english): gestational diabetes mellitus; metabolic syndrome; abdominal obesity; insulin resistance; adipokines
• Language: croatian
• URN:NBN: urn:nbn:hr:105:408802
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2024-06-26 13:58:06