Vrijeme od pojave simptoma do patohistološke dijagnoze u bolesnika oboljelih od nesitnostaničnog karcinoma pluća

master's thesis

• Title (english): Time from onset of symptoms to pathohistological diagnosis in patients with non-small cell lung cancer
• Author: Patricija Šimunić
• Mentor: Lovorka Batelja Vuletić (mentor)
• Committee member: Marjeta Majer (predsjednik povjerenstva)
• Committee member: Ognjen Brborović (član povjerenstva)
• Committee member: Lovorka Batelja Vuletić (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Pathology); Zagreb
• Defense date and country: 2024-07-12, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Pathology

Abstract

Karcinom pluća velik je javnozdravstveni problem u Hrvatskoj i svijetu. U Hrvatskoj, karcinom pluća drugi je po učestalosti i prvi po smrtnosti sa dobno standardiziranom stopama 47,2 na 100 000 stanovnika za incidenciju i 41,8 na 100 000 stanovnika za smrtnost. Cilj je ovog istraživanja bio ispitati razlikuje li se vremenski period do dijagnoze pacijenata s radnom dijagnozom karcinoma pluća ovisno o spolu, prisustvu ili odsustvu simptoma te s obzirom na godinu dijagnoze i promijenjene uvjete rada u zagrebačkim bolnicama. Ukupno 426 ispitanika podijeljeno je u dvije skupine ovisno o godini dijagnoze (2018. i 2022. godina), a unutar skupine na simptomatske i asimptomatske. U asimptomatskih je bolesnika promatrano vrijeme od slučajnog nalaza suspektne neoplazme pluća radiološkom obradom drugog stanja/bolesti do postupka biopsije s ciljem patohistološke dijagnoze. U simptomatskih je bolesnika promatrano vrijeme od pojave simptoma do prvog pregleda pulmologa te vrijeme ukupne dijagnostičke obrade od prvog pregleda pulmologa do postupka biopsije. Uočena je statistički značajna razlika u ukupnom vremenu dijagnostičke obrade simptomatskih žena i muškaraca 2018. godine (p = 0,019) te 2022. godine (p = 0,050) pri čemu je vrijeme od prvog pregleda pulmologa do postupka biopsije u žena znatno duže nego u muškaraca. Također, svi su dijagnostički vremenski intervali duži u 2022. godini u odnosu na 2018. godinu što se objašnjava posljedicama epidemije COVID-19 te stanjem zagrebačkim bolnica nakon potresa. Nasuprot tome, u 2022. godini vremenski je interval od pojave simptoma do prvog pregleda pulmologa bio kraći nego 2018. godine što govori u prilog prepoznavanju simptoma od strane pacijenata, njihovom ranijem obraćanju svom liječniku obiteljske medicine, kao i kraćem
vremenu potrebnom do prvog specijalističkog pregleda.

Abstract (english)

Lung cancer is a major public health problem in Croatia and in the world. In Croatia, lung cancer is the second in frequency and the first in mortality with age-standardized rates of 47.2 per 100,000 for incidence and 41.8 per 100,000 for mortality.
This research aimed to examine whether the diagnostic period of patients with a working diagnosis of lung cancer differs depending on gender, the presence or absence of symptoms, and with regard to the year of diagnosis and changed working conditions in Zagreb hospitals. A total of 426 subjects were divided into two groups depending on the year of diagnosis (2018 and 2022), and within the group into symptomatic and asymptomatic. In asymptomatic patients, the time from the accidental finding of a suspected lung neoplasm by radiological treatment of another condition/disease to the biopsy procedure with the aim of pathohistological diagnosis was observed. In symptomatic patients, the time from the onset of symptoms to the first examination by a pulmonologist and the total diagnostic processing time from the first examination by a pulmonologist to the biopsy procedure were observed. A statistically significant difference was observed between the duration of diagnostic processing of symptomatic women and men in 2018 (p = 0.019) and in 2022 (p = 0.050), whereby the time from the first examination by a pulmonologist to the biopsy procedure was significantly longer in women than in men. Additionally, all diagnostic time intervals were longer in 2022 compared to 2018, which could be explained by the consequences of the COVID-19 epidemic and the condition of the Zagreb hospital after the earthquake. In contrast, in 2022, the time interval from the appearance of symptoms to the first examination by a pulmonologist was shorter than in 2018, which speaks in favor of better patient symptom recognition, patients' earlier contact with their family medicine doctor, as well as shorter time required until the first specialist examination.

• Keywords: karcinom pluća; spolne razlike; biopsija
• Keywords (english): lung cancer; gender differences; biopsy
• Language: croatian
• URN:NBN: urn:nbn:hr:105:603624
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2024-06-30 17:23:22