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Distribution of Epstein–Barr Virus LMP1 Variants in Patients with Infectious Mononucleosis and Association with Selected Biochemical and Hematological Parameters
Pathogens, 12 (2023), 7; 915. https://doi.org/10.3390/pathogens12070915
Židovec-Lepej, Snježana; Batović, Margarita; Rožman, Marija; Bodulić, Kristian; Prtorić, Laura; Šokota, Ante; Nikćević, Andrea; Šimičić, Petra; Tešović, Goran

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Židovec Lepej, S., Batović, M., Rožman, M., Bodulić, K., Prtorić, L., Šokota, A. ... Tešović, G. (2023). Distribution of Epstein–Barr Virus LMP1 Variants in Patients with Infectious Mononucleosis and Association with Selected Biochemical and Hematological Parameters. Pathogens, 12. (7). doi: 10.3390/pathogens12070915

Židovec Lepej, Snježana, et al. "Distribution of Epstein–Barr Virus LMP1 Variants in Patients with Infectious Mononucleosis and Association with Selected Biochemical and Hematological Parameters." Pathogens, vol. 12, br. 7, 2023. https://doi.org/10.3390/pathogens12070915

Židovec Lepej, Snježana, Margarita Batović, Marija Rožman, Kristian Bodulić, Laura Prtorić, Ante Šokota, Andrea Nikćević, Petra Šimičić i Goran Tešović. "Distribution of Epstein–Barr Virus LMP1 Variants in Patients with Infectious Mononucleosis and Association with Selected Biochemical and Hematological Parameters." Pathogens 12, br. 7 (2023). https://doi.org/10.3390/pathogens12070915

Židovec Lepej, S., et al. (2023) 'Distribution of Epstein–Barr Virus LMP1 Variants in Patients with Infectious Mononucleosis and Association with Selected Biochemical and Hematological Parameters', Pathogens, 12(7). doi: 10.3390/pathogens12070915

Židovec Lepej S, Batović M, Rožman M, Bodulić K, Prtorić L, Šokota A, i sur.. Distribution of Epstein–Barr Virus LMP1 Variants in Patients with Infectious Mononucleosis and Association with Selected Biochemical and Hematological Parameters. Pathogens [Internet]. 06.07.2023. [pristupljeno 05.10.2024.];12(7). doi: 10.3390/pathogens12070915

S. Židovec Lepej, et al., "Distribution of Epstein–Barr Virus LMP1 Variants in Patients with Infectious Mononucleosis and Association with Selected Biochemical and Hematological Parameters", Pathogens, vol. 12, br. 7, Srpanj 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:436734. [Citirano: 05.10.2024.]

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Naslov (engleski)Distribution of Epstein–Barr Virus LMP1 Variants in Patients with Infectious Mononucleosis and Association with Selected Biochemical and Hematological Parameters
AutorSnježana Židovec-Lepej
AutorMargarita Batović
AutorMarija Rožman
AutorKristian Bodulić
AutorLaura Prtorić
AutorAnte Šokota
AutorAndrea Nikćević
AutorPetra Šimičić
AutorGoran Tešović
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA INFEKTOLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Infektologija
Sažetak (engleski)
The molecular diversity of Epstein–Barr virus (EBV) is exceptionally complex and based on the characterization of sequences coding for several viral genes. The aim of this study was to analyze the distribution of EBV types 1 and 2 and to characterize LMP1 variants in a cohort of 73 patients with infectious mononucleosis (IM), as well as to investigate a possible association between viral diversity and relevant clinical parameters. Population-based sequencing of EBNA-2 gene showed the presence of EBV type 1 in all IM patients. Analysis of LMP1 gene found a restricted repertoire of LMP1 variants with the predominance of wild-type B95-8, China1, Mediterranean and North Carolina variants with the presence of more than one LMP1 variant in 16.4% of patients. Co-infections with different LMP1 variants were associated with significantly higher levels of C-reactive protein and lower levels of maximal neutrophil counts and minimal platelet count. The results of this study have shown a narrow repertoire of LMP1 variants and an exclusive presence of EBV type 1 in a cohort of IM from Croatia, suggesting a characteristic local molecular pattern of this virus. The clinical importance of distinct immunobiological features of IM patients with LMP1 variant co-infections needs to be investigated further.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaPathogens
Brojčani podacivol. 12, br. 7, 915
e-ISSN2076-0817
DOIhttps://doi.org/10.3390/pathogens12070915
URN:NBNurn:nbn:hr:105:436734
Datum objave publikacije2023-07-06
ProjektŠifra: IP-2020-02-8961
Naziv (hrvatski): Molekularna raznolikost virusa Epstein-Barr
Naziv (engleski): Molecular diversity of Epstein-Barr virus
Kratica: MRVEB / MDEBV
Voditelj: Snježana Židovec-Lepej
Pravna nadležnost: Hrvatska
Financijer: Hrvatska zaklada za znanost
Linija financiranja: Research Projects
URL dokumentahttps://www.mdpi.com/2076-0817/12/7/915
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2024-09-04 09:15:20