Periprocedural myocardial and renal injury in patients undergoing elective percutaneous coronary interventions – is there an association?

Znanstveni rad - Izvorni znanstveni rad

• Autor: Mario Stipinović
• Autor: Luka Perčin
• Autor: Vedran Radonić
• Autor: Helena Jerkić
• Autor: Ivana Jurin
• Autor: Tomislav Letilović
• Autorova ustanova: Sveučilište u Zagrebu; Medicinski fakultet; (KATEDRA ZA INTERNU MEDICINU)
• Znanstveno / umjetničko područje, polje i grana: BIOMEDICINA I ZDRAVSTVO; Kliničke medicinske znanosti; Interna medicina

Sažetak (engleski)

Periprocedural myocardial injury (PMI) and contrast-induced nephropathy (CIN) are frequent complications of percutaneous coronary intervention (PCI) associated with early and late major adverse cardiovascular events. Both conditions are associated with similar risk factors, which could imply their possible association. The aim of our study was to assess the correlation of PMI and early postprocedural creatinine shift (ECS) as a marker of renal injury.A total of 209 hospitalized patients with stable coronary artery disease (CAD) were enrolled, who underwent an elective PCI in a period of 12 months. All patients had their serum high-sensitivity troponin I (hsTnI) measured at baseline and 16 hours after the PCI. PMI was defined according to the elevation of postprocedural hsTnI using criteria provided by both the most recent consensus documents as well as evidence-based data. Renal injury was evaluated using the ECS concept. Serum creatinine (SCr) was also measured at baseline and at 16 hours. ECS was defined as SCr >5% at 16 hours compared to baseline.Although incidence of both PMI (77.5%) and ECS (44.5%) were high, no association of these 2 conditions could be found. Further analyses of our data showed that diabetes is associated with a higher incidence of ECS, while patients on beta-blocker therapy had a lower incidence of ECS.In our study, no association between PMI and ECS was found. Additional studies with a larger number of patients and longer patient observation are needed to assess the correlation between PMI and CIN as well as to validate the attractive, but controversial, concept of ECS as an early marker of CIN.

• Ključne riječi (hrvatski): Acute Kidney Injury / blood; Acute Kidney Injury / chemically induced; Acute Kidney Injury / epidemiology; Aged; Biomarkers / blood; Contrast Media / adverse effects; Coronary Artery Disease / surgery; Creatinine / blood; Cross-Sectional Studies; Elective Surgical Procedures; Female; Heart Injuries / blood; Heart Injuries / epidemiology; Heart Injuries / etiology; Humans; Incidence; Male; Middle Aged; Percutaneous Coronary Intervention / adverse effects; Postoperative Complications / blood; Postoperative Complications / epidemiology; Postoperative Complications / etiology; Postoperative Period; Risk Factors; Troponin I / blood
• Jezik: engleski
• Vrsta publikacije: Znanstveni rad - Izvorni znanstveni rad
• Status objave: Objavljen
• Vrsta recenzije: Recenziran
• Verzija publikacije: Objavljena verzija rada (izdavačev PDF)
• Naslov časopisa: Medicine
• Brojčani podaci: vol. 98, br. 43, e16989
• p-ISSN: 0025-7974
• e-ISSN: 1536-5964
• DOI: https://doi.org/10.1097/MD.0000000000016989
• URN:NBN: urn:nbn:hr:105:426543
• Datum objave publikacije: 2019-10
• URL dokumenta: http://journals.lww.com/00005792-201910250-00001
• Vrsta resursa: Tekst
• Prava pristupa: Otvoreni pristup
• Datum i vrijeme pohrane: 2021-03-02 08:53:27