prikaz prve stranice dokumenta Artificial oocyte activation may improve embryo quality in older patients with diminished ovarian reserve undergoing IVF-ICSI cycles
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Artificial oocyte activation may improve embryo quality in older patients with diminished ovarian reserve undergoing IVF-ICSI cycles
Journal of Ovarian Research, 15 (2022), 1; 102. https://doi.org/10.1186/s13048-022-01036-7
Tsai, Tzung-En; Lin, Pei-Hsuan; Lian, Pei-Fen; Li, Chia-Jung; Vitale, Salvatore Giovanni; Mikuš, Mislav; Su, Wan-Ping; Tsai, Hsiao-Wen; Tsui, Kuan-Hao; Lin, Li-Te

Citirajte ovaj rad

Tsai, T. E., Lin, P. H., Lian, P. F., Li, C. J., Vitale, S. G., Mikuš, M. ... Lin, L. T. (2022). Artificial oocyte activation may improve embryo quality in older patients with diminished ovarian reserve undergoing IVF-ICSI cycles. Journal of Ovarian Research, 15. (1). doi: 10.1186/s13048-022-01036-7

Tsai, Tzung En, et al. "Artificial oocyte activation may improve embryo quality in older patients with diminished ovarian reserve undergoing IVF-ICSI cycles." Journal of Ovarian Research, vol. 15, br. 1, 2022. https://doi.org/10.1186/s13048-022-01036-7

Tsai, Tzung En, Pei Hsuan Lin, Pei Fen Lian, Chia Jung Li, Salvatore Giovanni Vitale, Mislav Mikuš, Wan Ping Su, Hsiao Wen Tsai, Kuan Hao Tsui i Li Te Lin. "Artificial oocyte activation may improve embryo quality in older patients with diminished ovarian reserve undergoing IVF-ICSI cycles." Journal of Ovarian Research 15, br. 1 (2022). https://doi.org/10.1186/s13048-022-01036-7

Tsai, T. E., et al. (2022) 'Artificial oocyte activation may improve embryo quality in older patients with diminished ovarian reserve undergoing IVF-ICSI cycles', Journal of Ovarian Research, 15(1). doi: 10.1186/s13048-022-01036-7

Tsai TE, Lin PH, Lian PF, Li CJ, Vitale SG, Mikuš M, i sur.. Artificial oocyte activation may improve embryo quality in older patients with diminished ovarian reserve undergoing IVF-ICSI cycles. Journal of Ovarian Research [Internet]. 09.09.2022. [pristupljeno 07.10.2024.];15(1). doi: 10.1186/s13048-022-01036-7

T. E. Tsai, et al., "Artificial oocyte activation may improve embryo quality in older patients with diminished ovarian reserve undergoing IVF-ICSI cycles", Journal of Ovarian Research, vol. 15, br. 1, Rujan 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:882686. [Citirano: 07.10.2024.]

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Naslov (engleski)Artificial oocyte activation may improve embryo quality in older patients with diminished ovarian reserve undergoing IVF-ICSI cycles
AutorTzung-En Tsai
AutorPei-Hsuan Lin
AutorPei-Fen Lian
AutorChia-Jung Li
AutorSalvatore Giovanni Vitale
AutorMislav Mikuš
AutorWan-Ping Su
AutorHsiao-Wen Tsai
AutorKuan-Hao Tsui
AutorLi-Te Lin
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA GINEKOLOGIJU I OPSTETRICIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Ginekologija i opstetricija
Sažetak (engleski)
Background: Artificial oocyte activation (AOA) is used to improve fertilization rate following fertilization failure after intracytoplasmic sperm injection (ICSI). Several studies have also shown that AOA may be involved in embryo development. Women with poor ovarian response are more likely to encounter in vitro fertilization (IVF) failure due to poor embryo quality. The aim of this study was to investigate whether AOA could improve embryo quality in older patients with diminished ovarian reserve undergoing IVF-ICSI cycles. ----- Methods: The retrospective cohort study consisted of 308 patients who fulfilled the POSEIDON Group 4 criteria and received IVF-ICSI cycles. The study group included 91 patients receiving AOA with calcium ionophores following ICSI. A total of 168 patients in the control group underwent ICSI without AOA. The baseline and cycle characteristics and embryo quality were compared between the two groups. ----- Results: At baseline, there were more IVF attempts, greater primary infertility, higher basal FSH levels and lower anti-Müllerian hormone (AMH) levels in the AOA group than in the non-AOA group. In terms of embryo quality, there were higher cleavage rates and top-quality Day 3 embryo (TQE) rates, as well as higher percentages of more than 1 TQE and TQE rates ≥50 in the AOA group than in the non-AOA group. The multivariate analysis revealed that AOA was positively associated with more than 1 TQE (adjusted OR 3.24, 95% CI 1.63-6.45, P = 0.001) and a TQE rate ≥ 50 (adjusted OR 2.14, 95% CI 1.20-3.80, P = 0.010). When the study population was divided into 2 subgroups based on the age of 40 years old, the beneficial effects of AOA on embryo quality were only observed in the subgroup of age ≥ 40 years old. ----- Conclusions: Our data suggest that AOA with calcium ionophores may improve embryo quality in older patients with diminished ovarian reserve undergoing IVF-ICSI cycles, especially in women aged ≥40 years.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJournal of Ovarian Research
Brojčani podacivol. 15, br. 1, 102
e-ISSN1757-2215
DOIhttps://doi.org/10.1186/s13048-022-01036-7
URN:NBNurn:nbn:hr:105:882686
Datum objave publikacije2022-09-09
URL dokumentahttps://ovarianresearch.biomedcentral.com/articles/10.1186/s13048-022-01036-7
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2023-02-16 12:03:57