prikaz prve stranice dokumenta Alzheimer's disease and type 2 diabetes: the association study of polymorphisms in tumor necrosis factor-alpha and apolipoprotein E genes
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Alzheimer's disease and type 2 diabetes: the association study of polymorphisms in tumor necrosis factor-alpha and apolipoprotein E genes
Metabolic Brain Disease, 27 (2012), 4; 507-512. https://doi.org/10.1007/s11011-012-9310-1
Mustapić, Maja; Popović Hadžija, Marijana; Pavlović, Mladen; Pavković, Pajica; Presečki, Paola; Mrazovac, Danijela; Mimica, Ninoslav; Korolija, Marina; Pivac, Nela; Muck-Šeler, Dorotea

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Mustapić, M., Popović Hadžija, M., Pavlović, M., Pavković, P., Presečki, P., Mrazovac, D. ... Muck Šeler, D. (2012). Alzheimer's disease and type 2 diabetes: the association study of polymorphisms in tumor necrosis factor-alpha and apolipoprotein E genes . Metabolic Brain Disease, 27. (4), 507-512. doi: 10.1007/s11011-012-9310-1

Mustapić, Maja, et al. "Alzheimer's disease and type 2 diabetes: the association study of polymorphisms in tumor necrosis factor-alpha and apolipoprotein E genes ." Metabolic Brain Disease, vol. 27, br. 4, 2012, str. 507-512. https://doi.org/10.1007/s11011-012-9310-1

Mustapić, Maja, Marijana Popović Hadžija, Mladen Pavlović, Pajica Pavković, Paola Presečki, Danijela Mrazovac, Ninoslav Mimica, Marina Korolija, Nela Pivac i Dorotea Muck Šeler. "Alzheimer's disease and type 2 diabetes: the association study of polymorphisms in tumor necrosis factor-alpha and apolipoprotein E genes ." Metabolic Brain Disease 27, br. 4 (2012): 507-512. https://doi.org/10.1007/s11011-012-9310-1

Mustapić, M., et al. (2012) 'Alzheimer's disease and type 2 diabetes: the association study of polymorphisms in tumor necrosis factor-alpha and apolipoprotein E genes ', Metabolic Brain Disease, 27(4), str. 507-512. doi: 10.1007/s11011-012-9310-1

Mustapić M, Popović Hadžija M, Pavlović M, Pavković P, Presečki P, Mrazovac D, i sur.. Alzheimer's disease and type 2 diabetes: the association study of polymorphisms in tumor necrosis factor-alpha and apolipoprotein E genes . Metabolic Brain Disease [Internet]. 12.2012. [pristupljeno 07.10.2024.];27(4):507-512. doi: 10.1007/s11011-012-9310-1

M. Mustapić, et al., "Alzheimer's disease and type 2 diabetes: the association study of polymorphisms in tumor necrosis factor-alpha and apolipoprotein E genes ", Metabolic Brain Disease, vol. 27, br. 4, str. 507-512, Prosinac 2012. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:834524. [Citirano: 07.10.2024.]

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Podaci o radu
Naslov (engleski)Alzheimer's disease and type 2 diabetes: the association study of polymorphisms in tumor necrosis factor-alpha and apolipoprotein E genes
AutorMaja Mustapić
AutorMarijana Popović Hadžija
AutorMladen Pavlović
AutorPajica Pavković
AutorPaola Presečki
AutorDanijela Mrazovac
AutorNinoslav Mimica
AutorMarina Korolija
AutorNela Pivac
AutorDorotea Muck-Šeler
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Type 2 diabetes (T2D) and Alzheimer's disease (AD) are two progressive disorders with high prevalence worldwide. Polymorphisms in tumor necrosis factor-alpha (TNF-?) and apolipoprotein E (ApoE) genes might be associated with both T2D and AD, representing possible genetic markers for the development of the AD in subjects with T2D. The aim was to determine ApoE and G-308A TNF-? gene polymorphisms in unrelated Croatian Caucasians: 207 patients with sporadic AD, 196 T2D patients and 456 healthy controls. Patients with AD had higher frequency of ApoE4 allele compared to T2D patients and controls. The significant association, observed between ApoE2 allele and T2D, disappeared after the data were adjusted for age and sex. The genotype or allele frequencies of G-308A TNF-? gene polymorphism were similar among the patients with AD, T2D and healthy controls. In conclusion, these results do not support the hypothesis that the A allele of G-308A TNF-? gene polymorphism is associated either with AD or T2D. Our data confirm the association between the ApoE4 allele and AD, and point out the E2 allele of ApoE gene as the possible risk factor for T2D.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaMetabolic Brain Disease
Brojčani podacivol. 27, br. 4, str. 507-512
p-ISSN0885-7490
DOIhttps://doi.org/10.1007/s11011-012-9310-1
URN:NBNurn:nbn:hr:105:834524
Datum objave publikacije2012-12
URL dokumentahttps://doi.org/10.1007/s11011-012-9310-1
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-27 19:36:24