prikaz prve stranice dokumenta Risk factors for development and progression of nonproliferative retinopathy in normoalbuminuric patients with type 1 diabetes
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Risk factors for development and progression of nonproliferative retinopathy in normoalbuminuric patients with type 1 diabetes
Diabetes Research and Clinical Practice, 106 (2014), 3; 555-559. https://doi.org/10.1016/j.diabres.2014.09.018
Bulum, Tomislav; Blaslov, Kristina; Duvnjak, Lea

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Bulum, T., Blaslov, K. i Duvnjak, L. (2014). Risk factors for development and progression of nonproliferative retinopathy in normoalbuminuric patients with type 1 diabetes. Diabetes Research and Clinical Practice, 106. (3), 555-559. doi: 10.1016/j.diabres.2014.09.018

Bulum, Tomislav, et al. "Risk factors for development and progression of nonproliferative retinopathy in normoalbuminuric patients with type 1 diabetes." Diabetes Research and Clinical Practice, vol. 106, br. 3, 2014, str. 555-559. https://doi.org/10.1016/j.diabres.2014.09.018

Bulum, Tomislav, Kristina Blaslov i Lea Duvnjak. "Risk factors for development and progression of nonproliferative retinopathy in normoalbuminuric patients with type 1 diabetes." Diabetes Research and Clinical Practice 106, br. 3 (2014): 555-559. https://doi.org/10.1016/j.diabres.2014.09.018

Bulum, T., Blaslov, K. i Duvnjak, L. (2014) 'Risk factors for development and progression of nonproliferative retinopathy in normoalbuminuric patients with type 1 diabetes', Diabetes Research and Clinical Practice, 106(3), str. 555-559. doi: 10.1016/j.diabres.2014.09.018

Bulum T, Blaslov K, Duvnjak L. Risk factors for development and progression of nonproliferative retinopathy in normoalbuminuric patients with type 1 diabetes. Diabetes Research and Clinical Practice [Internet]. 12.2014. [pristupljeno 29.09.2024.];106(3):555-559. doi: 10.1016/j.diabres.2014.09.018

T. Bulum, K. Blaslov i L. Duvnjak, "Risk factors for development and progression of nonproliferative retinopathy in normoalbuminuric patients with type 1 diabetes", Diabetes Research and Clinical Practice, vol. 106, br. 3, str. 555-559, Prosinac 2014. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:747710. [Citirano: 29.09.2024.]

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Podaci o radu
Naslov (engleski)Risk factors for development and progression of nonproliferative retinopathy in normoalbuminuric patients with type 1 diabetes
AutorTomislav Bulum
AutorKristina Blaslov
AutorLea Duvnjak
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
BACKGROUND: The aim of this study was to evaluate risk factors for development and progression of nonproliferative retinopathy (NPR) in normoalbuminuric patients with type 1 diabetes mellitus (T1DM). ----- METHODS: A total of 223 T1DM with normal renal function and normoalbuminuria were included in this study and followed for 48 months. Photodocumented retinopathy status was made according to the EURODIAB protocol. Urinary albumin excretion rate (UAE) was measured from at least two 24-h urine samples. Possible risk factors for development or progression of NPR were examined in backward stepwise Cox's multiple regression analysis. ----- RESULTS: The majority of patients (70%) had no retinopathy while 67 (30%) had NPR at baseline. Patients with NPR were older, had longer duration of diabetes, higher systolic blood pressure, BMI, resting heart rate, UAE and lower estimated glomerular filtration rate (p ≤ 0.04 for all). After 48 months 24 patients (10.7%) developed NPR or progressed to proliferative retinopathy. Systolic blood pressure (HR 1.03, CI 1.01-1.05, p=0.02), UAE (HR 1.14, CI 1.07-1.21, p<0.001), and resting heart rate (HR 1.05, CI 1.01-1.09, p=0.006) were significantly associated with development or progression of NPR. ----- CONCLUSIONS: Our results suggest that retinopathy is present and may progress in T1DM even when coexisting renal disease is excluded. Normoalbuminuric T1DM requires close monitoring for the early detection of retinopathy, especially if they have a higher UAE, systolic blood pressure and resting heart rate.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaDiabetes Research and Clinical Practice
Brojčani podacivol. 106, br. 3, str. 555-559
p-ISSN0168-8227
DOIhttps://doi.org/10.1016/j.diabres.2014.09.018
URN:NBNurn:nbn:hr:105:747710
Datum objave publikacije2014-12
URL dokumentahttps://doi.org/10.1016/j.diabres.2014.09.018
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2024-03-28 08:32:33