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Testovi za procjenu ataksije u djece
Testovi za procjenu ataksije u djece
Matea Senta
Glavna funkcija malog mozga je koordinacija pokreta i održavanje ravnoteže. Oštećenjem malog mozga i njegovih veza sa ostalim dijelovima živčanog sustava nastaje ataksija to jest poremećaj koordinacije voljnih pokreta udova i trupa. Simptomi se očituju kao poremećaj održavanja ravnoteže, stajanja, hodanja, sjedenja, koordinacije pokreta udova, poremećajem govora i okulomotoričkim poremećajem. Ataksije se mogu podijeliti s obzirom na uzrok na stečene i nasljedne. Stečene mogu...
Teški metali sa svojstvima endokrinih disruptora
Teški metali sa svojstvima endokrinih disruptora
Antonia Dedo
Broj kemijskih tvari kojima su ljudi izloženi tijekom proteklih stotinu godina dramatično se povećao. Međutim, veliki broj kemijskih tvari, prirodnih i sintetiziranih, ima svojstvo imitacije prirodnih hormona. Te kemijske tvari, koje ulaskom u organizam mogu se vezati na hormonske receptore, te na taj način remetiti normalnu funkciju hormona, nazivamo endokrini disruptori. Endokrini disruptori imaju sposobnost oponašanja aktivnosti endogenih hormona i postizanja ekvivalentnih...
The complexity of malnutrition in cystic fibrosis
The complexity of malnutrition in cystic fibrosis
Romana Prskalo
Cystic Fibrosis (CF) is the most common life-limiting genetic disease of Caucasian populations. It is a disease inherited in an autosomal recessive fashion and the defect lies in the gene encoding the cystic fibrosis transmembrane regulator (CFTR) - a chloride channel regulating ion transport across the apical surface of secretory epithelial cells. The main clinical manifestations are pancreatic insufficiency and progressive obstructive pulmonary and gastrointestinal disease. Malnutrition in...
The ever growing complexity of trophoblast epigenetics
The ever growing complexity of trophoblast epigenetics
Katharina Alexandra Schmidt
Mammalian placentation is closely regulated by the actions of trophoblast cells at the time of implantation. Invasion of trophoblast into uterine tissue is an essential process in placentation and appropriate fetal development. Since human trophoblast is responsible for appropriate fetal growth, it is of major interest in the field of medicine, particularly in understanding how it is influenced by different processes and environmental conditions. This review is sought to give an insight into...
The impact of changes in neonatal intensive care practices on short-term outcomes of premature infants
The impact of changes in neonatal intensive care practices on short-term outcomes of premature infants
Anna Mara Hrgetić Vitols
OBJECTIVE: To assess the changes in neonatal care practices at the NICU-UHC Zagreb and their impact on short-term morbidity of a cohort of premature infants. A comparison between two epochs was performed, the periods before and after changes in respiratory support, healthcare professionals' attitudes and practices in supporting and promoting the breastfeeding, and laboratory phlebotomy reduction was introduced. ----- METHODS: We performed a retrospective study to investigate short-term...
The prevalence of cardiovascular risks in HIV-infected persons in care in Croatia in 2015
The prevalence of cardiovascular risks in HIV-infected persons in care in Croatia in 2015
Ivan Raymond Marius Desbordes
Aim:This review will aim at considering the prevalence of cardiovascular risks among the HIV-infected population undergoing ART therapy in Croatia: Cardiovascular diseases are now among the most common causes of mortality in people living with HIV. We will see for which reasons people living with HIV appear to have an elevated risk for cardiovascular diseases. ----- Method: A cross-sectional analysis of 310 consecutive HIV infected patients seen during a routine clinical visit aged 40 to 79...
The relationship between doctor's health and safe patient care
The relationship between doctor's health and safe patient care
Amanda Josephine Lam
Safe patient care is an aspect of healthcare that is becoming increasingly recognized by the world’s healthcare professionals as a crucial component of optimal patient outcome. Patient safety places emphasis on a physician’s duty to report, analyze and prevent medical errors. Safe patient care is highly dependent upon a competent and functioning physician. The psychological and physical health of a doctor is vital in ensuring safe patient outcome. Today’s medical professionals have...
The role of adipokines in polycystic ovary syndrome
The role of adipokines in polycystic ovary syndrome
Maja Šikić
Polycystic ovary syndrome (PCOS) is an exceedingly complex endocrine, reproductive and metabolic disorder of a diverse and still unclear pathogenesis. PCOS affects approximately 10% of women of reproductive age and is considered one of the most common endocrine and reproductive disturbances in its group (1)(2). The syndrome is clinically characterised by oligo/anovulation and infertility, hirsutism and abdominal obesity (3). However, the absence of clearly defined causative factors and...
The role of platelet tests in detection of clopidogrel hyper-response after percutaneous coronary intervention
The role of platelet tests in detection of clopidogrel hyper-response after percutaneous coronary intervention
Michael John Grašić
Clopidogrel is a PY212 antiplatelet medication which was shown to reduce mortality in patients post PCI. A percentage of the population has a resultant low platelet reactivity (LPR) or high platelet reactivity (HPR) while taking Clopidogrel. There is a connection between the LPR and increased rates of bleeding events as well as a connection between HPR and increased rates of ST events. We will examine bleeding avoidant strategies (BAS) which may be implemented to reduce bleeding event in...
The role of the FaS/FasL apoptotic pathway on osteoclastogenesis in the mouse model of controlled tibial fractures
The role of the FaS/FasL apoptotic pathway on osteoclastogenesis in the mouse model of controlled tibial fractures
Nina Lukač
The Fas/FasL apoptotic system serves as a regulator of the immune system, but also has an influence on osteoclast survival and differentiation. The model of internally fixated controlled tibial fractures was used to evaluate its role on osteoclastogenesis in formation of new bone, as fracture healing serves as a model for embryonic skeletal development. The aim of this study was to evaluate the role of the apoptotic system on osteoclastogenesis in vivo, by evaluating the osteoclastogenic...
The usage of antibiotics in bone surgery
The usage of antibiotics in bone surgery
Patrick Julien Bernard Tschechne
The discovery of antibiotics has drastically changed modern medicine and everyday human life. Even though extraordinary discoveries have been made perioperative infections are still commonly encountered in clinical practice. Deep infections such as septic arthritis, osteomyelitis and periprosthetic joint infections pose great difficulties to practising surgeons and increase the financial burden for health care systems across the globe. Multiple antibiotic regimens are commonly used where...
The use of lasers in dermatology
The use of lasers in dermatology
Kristina Žužul
This graduate thesis explains the basic laser principles and provides an overview of indications for laser treatment in dermatology. The term laser is an acronym for light amplification by the stimulated emission of radiation. Since the development of first laser by Maiman and the introduction of theory of selective photothermolysis in 1980 by Anderson and Parish, it gained widespread acceptance in dermatology and is now used for the treatment of numerous cutaneous conditions including...

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