Bilateral Meningioma: A Case Report and Review of the Literature

Znanstveni rad - Pregledni rad

• Autor: Anja Bukovac
• Autor: Hana Panić
• Autor: Tomislava Mrgan
• Autor: Nika Šlaus
• Autor: Anja Kafka
• Autor: Niko Njirić
• Autor: Nives Pećina-Šlaus
• Autorova ustanova: Sveučilište u Zagrebu; Medicinski fakultet; (HRVATSKI INSTITUT ZA ISTRAŽIVANJE MOZGA)
• Autorova ustanova: Sveučilište u Zagrebu; Medicinski fakultet; (KATEDRA ZA MEDICINSKU BIOLOGIJU)
• Znanstveno / umjetničko područje, polje i grana: BIOMEDICINA I ZDRAVSTVO; Temeljne medicinske znanosti; Neuroznanost
• Znanstveno / umjetničko područje, polje i grana: BIOMEDICINA I ZDRAVSTVO; Kliničke medicinske znanosti; Klinička biokemija

Sažetak (engleski)

Here, we present a rarely seen example of bilateral meningiomas exhibiting different malignancy grades, I (meningothelial) and II (atypical), recorded in a 72-year-old patient. The presence of two separated lesions of different grades in a single patient can elucidate meningioma progression. To this end, the involvement of specific protein markers of epithelial to mesenchymal transition (EMT), the process responsible for progression, was tested in both tumors. Protein expression status of specific epithelial (E-cadherin) and mesenchymal markers (N-cadherin, SNAIL&SLUG and TWIST1) was investigated. Furthermore, markers that are connected to Wnt signaling pathway–beta-catenin, GSK3beta and DVL1—were also analyzed. For signs of neurofibromatosis and schwanomatosis genetic testing was performed. Immunohistochemistry evaluated by immunoreactivity score (IRS) was used to determine the signal strengths and proteins’ location. Our results indicated that, in comparison to the grade I tumor, mesenchymal markers SNAIL and SLUG were upregulated in the atypical meningioma. TWIST1, beta-catenin and GSK3beta were upregulated in both grades, while E-cadherin was partially lost. A pronounced cadherin switch could not be established; however, N-cadherin showed widespread tissue presence. Genetic testing did not detect changes of NF2 or SMARCB1 genes denying germline origin of the lesions. The rare presence of two different grades in one patient elucidate previously unknown molecules involved in meningioma progression.

• Ključne riječi (engleski): Aged; Biomarkers, Tumor / genetics; Female; Genetic Testing / methods; Humans; Meningeal Neoplasms / genetics; Meningeal Neoplasms / pathology; Meningioma / genetics; Meningioma / pathology
• Jezik: engleski
• Vrsta publikacije: Znanstveni rad - Pregledni rad
• Status objave: Objavljen
• Vrsta recenzije: Recenziran
• Verzija publikacije: Objavljena verzija rada (izdavačev PDF)
• Naslov časopisa: International Journal of Molecular Sciences
• Brojčani podaci: vol. 23, br. 3, 1187
• e-ISSN: 1422-0067
• DOI: https://doi.org/10.3390/ijms23031187
• URN:NBN: urn:nbn:hr:105:455509
• Datum objave publikacije: 2022-01-21
• Projekt: Šifra: KK.01.1.1.01.0007; Naziv (hrvatski): Eksperimentalna i klinička istraživanja hipoksijsko-ishemijskog oštećenja mozga u perinatalnoj i odrasloj dobi; Voditelj: Ivica Kostović; Pravna nadležnost: eu; Financijer: EK
• URL dokumenta: https://www.mdpi.com/1422-0067/23/3/1187
• Vrsta resursa: Tekst
• Prava pristupa: Otvoreni pristup
• Datum i vrijeme pohrane: 2022-10-20 08:19:56