Kronični rekurirajući multifokalni osteomijelitis

master's thesis

• Title (english): Chronic recurrent multifocal osteomyelitis
• Author: Lara Fotez
• Mentor: Porin Perić (mentor)
• Committee member: Iva Žagar (predsjednik povjerenstva)
• Committee member: Marija Bakula (član povjerenstva)
• Committee member: Porin Perić (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Physical Medicine and General Rehabilitation); Zagreb
• Defense date and country: 2024-07-12, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Physical Medicine and Rehabilitation

Abstract

Kronični rekurirajući multifokalni osteomijelitis (CRMO) kronična je neinfektivna autoinflamatorna osteoartropatija pedijatrijske populacije karakterizirana višestrukim upalnim sterilnim lezijama kostiju. Bolest se prvenstveno manifestira bolovima, pojačanima tijekom noći ili nakon fizičke aktivnosti, koji često ostanu neprepoznati jer se poistovjećuju s bolovima rasta kod djece. Stoga manjak informiranosti o CRMO otežava pravovremenu dijagnozu i početak terapije.
Cilj ovog rada jest uvodno prikazati osnovne koncepte iza nomenklature, povijesti i etiologije ove rijetke bolesti, moguće patogenetske mehanizme nastanka, kliničku sliku i pripadajuće diferencijalne dijagnoze. Zatim podrobnije opisati suvremene metode dijagnoze i dijagnostičke kriterije te najnovije algoritme liječenja i nove terapijske mogućnosti.

Abstract (english)

Chronic recurrent multifocal osteomyelitis (CRMO) is a chronic non-infectious autoinflammatory osteoarthropathy of the pediatric population characterized by multiple inflammatory sterile bone lesions. The disease is primarily manifested by pains, intensified during the night or after physical activity, which often remain unrecognized because they are identified with growing pains in children. Therefore, the lack of information about CRMO makes timely diagnosis and initiation of therapy difficult.
This paper aims to introduce the basic concepts behind the terminology, history, and etiology of this rare disease, possible pathogenetic mechanisms of its occurrence, clinical presentation, and related differential diagnoses. Then, it will present in more detail modern methods of diagnosis and diagnostic criteria, as well as the latest treatment algorithms and new therapeutic options.

• Keywords: kronični rekurirajući multifokalni osteomijelitis; kronični nebakterijski osteomijelitis
• Keywords (english): Chronic Recurrent Multifocal Osteomyelitis; Chronic Non-bacterial Osteomyelitis
• Language: croatian
• URN:NBN: urn:nbn:hr:105:490192
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2024-07-09 10:13:30