master's thesis
Regional differences in incidence, mortality, and prevalence of brain tumors in the Republic of Croatia

Valerija Korent (2016)
Sveučilište u Zagrebu
Medicinski fakultet
KATEDRA ZA KIRURGIJU
Metadata
TitleRegionalne razlike u incidenciji, mortalitetu i prevalenciji tumora mozga u Republici Hrvatskoj
AuthorValerija Korent
Mentor(s)Goran Mrak (thesis advisor)
Abstract
Incidencija moždanih tumora iznosi 8/100.000 stanovnika. Oko 75% moždanih tumora je benigne naravi, a ostatak otpada na maligne tumore. Maligni tumori mozga zauzimaju treće mjesto u grupi malignih oboljenja srednje životne dobi i na drugom su mjestu neuroloških uzroka smrtnosti, nakon cerebrovaskularnih bolesti. U dječjoj dobi su vodeći uzrok smrti, nakon leukemija. Kod odraslih osoba najčešći maligni tumor je glioblastom. Glavni cilj istraživanja je bio dobiti uvid u trendove incidencije i mortaliteta od tumora mozga prema dobu, spolu i županijama u razdoblju od 2001. do 2014. godine te prevalenciju na kraju 2014. godine u Hrvatskoj. Podaci o incidenciji malignih tumora mozga (dijagnoza C71 prema Međunarodnoj klasifikaciji bolesti, 10. izdanje) dobiveni su od Registra za rak Republike Hrvatske Hrvatskog zavoda za javno zdravstvo. Stope incidencije i mortaliteta na 100.000 stanovnika za Hrvatsku te prevalencija izračunate su prema procjenama stanovništva koje godišnje izdaje Državni zavod za statistiku, a dobno su standardizirane prema standardnom europskom stanovništvu (1976. godine). Prosječna stopa incidencije i mortaliteta izračunata je na temelju ukupnog broja slučajeva u tom četrnaestogodišnjem razdoblju podijeljenom s prosječnim brojem stanovnika u toj županiji prema procjenama stanovništva Državnog zavoda za statistiku. U razdoblju od 2001. do 2014. godine u Hrvatskoj su dijagnosticirana 6.634 slučaja tumora mozga (52% u muškaraca) te je bilo 5.379 smrti zbog tumora mozga (52% u muškaraca). Dobno specifične stope incidencije i mortaliteta od tumora mozga kod žena i muškaraca pokazuju trend pomaka prema starijoj životnoj dobi. Broj novih slučajeva kretao se u rasponu od 439 (2013. godine) do 506 (2011. godine) godišnje, a trendovi grubih stopa i standardiziranih stopa incidencije i mortaliteta ne pokazuju značajnijih odstupanja kroz navedeno razdoblje. Najviše dobno - standardizirane stope incidencije malignih tumora mozga u muškaraca zabilježene u Istarskoj, Zadarskoj i Splitsko - dalmatinskoj županiji, dok je mortalitet bio najviši u Šibensko - kninskoj, Dubrovačko - neretvanskoj i Požeško - slavonskoj županiji. Kod žena je incidencija bila najviša u Ličko - senjskoj, Istarskoj i Brodsko - posavskoj županiji, dok je mortalitet bio najviši u Požeško - slavonskoj, Brodsko - posavskoj i Dubrovačko - neretvanskoj županiji. Trend pojavnosti tumora mozga je konstantan, te zbog progresivnosti i niskih stopa preživljenja, predstavlja važan javnozdravstveni problem. U Hrvatskoj dodatni problem predstavlja neupućenost javnosti, manjak informativnog sadržaja, psihološka pomoć nije standardni dio liječenja te nedostupnost genetske dijagnostike. Potrebno je osigurati informativni materijal u bolnicama te ukazati na važnost što ranijeg dijagnosticiranja bolesti te osigurati dostupnost novijih terapijskih metoda s ciljem produljenja i poboljšanja kvalitete života.
KeywordsBrain tumours incidence mortality prevalence regional differences
Parallel title (English)Regional differences in incidence, mortality, and prevalence of brain tumors in the Republic of Croatia
Committee MembersJosip Paladino (committee chairperson)
Tomislav Meštrović (committee member)
Goran Mrak (committee member)
GranterSveučilište u Zagrebu
Medicinski fakultet
Lower level organizational unitsKATEDRA ZA KIRURGIJU
PlaceZagreb
StateCroatia
Scientific field, discipline, subdisciplineBIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Oncology
Study programme typeuniversity
Study levelgraduate
Study programmeStudies in Nursing
Academic title abbreviationmag. med. techn.
Genremaster's thesis
Language Croatian
Defense date2016-09-21
Parallel abstract (English)
The incidence of brain tumors is 8/100 000. About 75% of brain tumors is benign by nature, with the remaining part consisting of malignant tumors. Malignant tumors of the brain occupy third place in the group of malignant diseases of middle age people and are the second neurological cause of death, after cerebrovascular diseases. In childhood, brain tumors are the leading cause of death, after leukemia. In adults, the most common malignant tumor is glioblastoma. The main objective of the research was to gain insight into trends in the incidence and mortality of brain tumors according to age, gender and counties from 2001 to 2014, and the prevalence of this at the end of 2014 in Croatia. Data on the incidence of malignant brain tumors (C71 diagnosis according to the InternationalClassification of Diseases, 10th edition) were obtained from the Cancer Registry of the Republic of CroatiaInstitute for Public Health. Both the incidence and mortality rates per 100 000residents of Croatia and prevalence were calculated according to population estimateswhich are annually issued by the State Bureau of Statistics, and age-standardized toEuropean standard population (1976). The average incidence and mortality rate is calculated by the total number of cases in the fourteen-year perioddivided by the average number of inhabitants in the county according to population estimates of the Central Bureau of Statistics. In the period from 2001 to 2014 in Croatia there were 6,634 diagnosed cases of brain tumors (52% men)and 5,379 deaths were due to tumors of the brain (52% men). Age-specific incidence rates and mortality from brain tumors in women and men show a trend shift towards older age. The number of new cases ranged from 439 (2013) to 506 (2011) a year, a rough trend rate and standardized rate of incidence and mortality did not show significant differences in that period. Most age-standardized incidence rates of malignant brain tumors in males were recorded in Istria and Split-Dalmatia County, while the mortality rate was highest in Šibenik-Knin, Dubrovnik-Neretva and PoţegaSlavonia County. In women, the incidence was highest in Lika-Senj, Istria and Brod- Posavina, while the mortality rate was highest in Pozega-Slavonia, Brod-Posavina and Dubrovnik-Neretva County. The trend in the incidence of brain tumors is constant, and because of the progressivity and the lowsurvival rate, it presents an important health public health problem. Another problem in Croatia is the ignorance of the public, a lack of informative content, psychological help is not a standard part of treatment, and the unavailability of genetic diagnostics. It is necessary to provide information material in hospitals and highlight the importance of what early diagnosis and to ensure the availability of new therapeutic methods with the aim of extending and improving the quality of life.
Parallel keywords (Croatian)tumori mozga incidencija mortalitet prevalencija regionalne razlike
Resource typetext
Access conditionOpen access
Terms of usehttp://rightsstatements.org/vocab/InC/1.0/
URN:NBNhttps://urn.nsk.hr/urn:nbn:hr:105:576818
CommitterLovela Machala Poplašen