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Scientific paper - Original scientific paper
Distribution of Epstein–Barr Virus LMP1 Variants in Patients with Infectious Mononucleosis and Association with Selected Biochemical and Hematological Parameters
Pathogens, 12 (2023), 7; 915. https://doi.org/10.3390/pathogens12070915
Židovec-Lepej, Snježana; Batović, Margarita; Rožman, Marija; Bodulić, Kristian; Prtorić, Laura; Šokota, Ante; Nikćević, Andrea; Šimičić, Petra; Tešović, Goran

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Židovec Lepej, S., Batović, M., Rožman, M., Bodulić, K., Prtorić, L., Šokota, A. ... Tešović, G. (2023). Distribution of Epstein–Barr Virus LMP1 Variants in Patients with Infectious Mononucleosis and Association with Selected Biochemical and Hematological Parameters. Pathogens, 12. (7). doi: 10.3390/pathogens12070915

Židovec Lepej, Snježana, et al. "Distribution of Epstein–Barr Virus LMP1 Variants in Patients with Infectious Mononucleosis and Association with Selected Biochemical and Hematological Parameters." Pathogens, vol. 12, no. 7, 2023. https://doi.org/10.3390/pathogens12070915

Židovec Lepej, Snježana, Margarita Batović, Marija Rožman, Kristian Bodulić, Laura Prtorić, Ante Šokota, Andrea Nikćević, Petra Šimičić and Goran Tešović. "Distribution of Epstein–Barr Virus LMP1 Variants in Patients with Infectious Mononucleosis and Association with Selected Biochemical and Hematological Parameters." Pathogens 12, no. 7 (2023). https://doi.org/10.3390/pathogens12070915

Židovec Lepej, S., et al. (2023) 'Distribution of Epstein–Barr Virus LMP1 Variants in Patients with Infectious Mononucleosis and Association with Selected Biochemical and Hematological Parameters', Pathogens, 12(7). doi: 10.3390/pathogens12070915

Židovec Lepej S, Batović M, Rožman M, Bodulić K, Prtorić L, Šokota A, and sur.. Distribution of Epstein–Barr Virus LMP1 Variants in Patients with Infectious Mononucleosis and Association with Selected Biochemical and Hematological Parameters. Pathogens [Internet]. 2023 July 06 [cited 2024 October 12];12(7). doi: 10.3390/pathogens12070915

S. Židovec Lepej, et al., "Distribution of Epstein–Barr Virus LMP1 Variants in Patients with Infectious Mononucleosis and Association with Selected Biochemical and Hematological Parameters", Pathogens, vol. 12, no. 7, July 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:436734. [Accessed: 12 October 2024]

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Metadata
Title (english)Distribution of Epstein–Barr Virus LMP1 Variants in Patients with Infectious Mononucleosis and Association with Selected Biochemical and Hematological Parameters
AuthorSnježana Židovec-Lepej
AuthorMargarita Batović
AuthorMarija Rožman
AuthorKristian Bodulić
AuthorLaura Prtorić
AuthorAnte Šokota
AuthorAndrea Nikćević
AuthorPetra Šimičić
AuthorGoran Tešović
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Infectious Diseases)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Infectology
Abstract (english)
The molecular diversity of Epstein–Barr virus (EBV) is exceptionally complex and based on the characterization of sequences coding for several viral genes. The aim of this study was to analyze the distribution of EBV types 1 and 2 and to characterize LMP1 variants in a cohort of 73 patients with infectious mononucleosis (IM), as well as to investigate a possible association between viral diversity and relevant clinical parameters. Population-based sequencing of EBNA-2 gene showed the presence of EBV type 1 in all IM patients. Analysis of LMP1 gene found a restricted repertoire of LMP1 variants with the predominance of wild-type B95-8, China1, Mediterranean and North Carolina variants with the presence of more than one LMP1 variant in 16.4% of patients. Co-infections with different LMP1 variants were associated with significantly higher levels of C-reactive protein and lower levels of maximal neutrophil counts and minimal platelet count. The results of this study have shown a narrow repertoire of LMP1 variants and an exclusive presence of EBV type 1 in a cohort of IM from Croatia, suggesting a characteristic local molecular pattern of this virus. The clinical importance of distinct immunobiological features of IM patients with LMP1 variant co-infections needs to be investigated further.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titlePathogens
Numberingvol. 12, no. 7, 915
e-ISSN2076-0817
DOIhttps://doi.org/10.3390/pathogens12070915
URN:NBNurn:nbn:hr:105:436734
Publication2023-07-06
ProjectNumber: IP-2020-02-8961
Title (croatian): Molekularna raznolikost virusa Epstein-Barr
Title (english): Molecular diversity of Epstein-Barr virus
Acronym: MRVEB / MDEBV
Leader: Snježana Židovec-Lepej
Jurisdiction: Croatia
Funding stream: Research Projects
Document URLhttps://www.mdpi.com/2076-0817/12/7/915
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2024-09-04 09:15:20