prikaz prve stranice dokumenta Soluble TREM2 Concentrations in the Cerebrospinal Fluid Correlate with the Severity of Neurofibrillary Degeneration, Cognitive Impairment, and Inflammasome Activation in Alzheimer’s Disease
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Scientific paper - Original scientific paper
Soluble TREM2 Concentrations in the Cerebrospinal Fluid Correlate with the Severity of Neurofibrillary Degeneration, Cognitive Impairment, and Inflammasome Activation in Alzheimer’s Disease
Neurology International, 15 (2023), 3; 842-856. https://doi.org/10.3390/neurolint15030053
Španić Popovački, Ena; Babić Leko, Mirjana; Langer Horvat, Lea; Brgić, Klara; Vogrinc, Željka; Boban, Marina; Klepac, Nataša; Borovečki, Fran; Šimić, Goran

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Španić Popovački, E., Babić Leko, M., Langer Horvat, L., Brgić, K., Vogrinc, Ž., Boban, M. ... Šimić, G. (2023). Soluble TREM2 Concentrations in the Cerebrospinal Fluid Correlate with the Severity of Neurofibrillary Degeneration, Cognitive Impairment, and Inflammasome Activation in Alzheimer’s Disease. Neurology International, 15. (3), 842-856. doi: 10.3390/neurolint15030053

Španić Popovački, Ena, et al. "Soluble TREM2 Concentrations in the Cerebrospinal Fluid Correlate with the Severity of Neurofibrillary Degeneration, Cognitive Impairment, and Inflammasome Activation in Alzheimer’s Disease." Neurology International, vol. 15, no. 3, 2023, pp. 842-856. https://doi.org/10.3390/neurolint15030053

Španić Popovački, Ena, Mirjana Babić Leko, Lea Langer Horvat, Klara Brgić, Željka Vogrinc, Marina Boban, Nataša Klepac, Fran Borovečki and Goran Šimić. "Soluble TREM2 Concentrations in the Cerebrospinal Fluid Correlate with the Severity of Neurofibrillary Degeneration, Cognitive Impairment, and Inflammasome Activation in Alzheimer’s Disease." Neurology International 15, no. 3 (2023): 842-856. https://doi.org/10.3390/neurolint15030053

Španić Popovački, E., et al. (2023) 'Soluble TREM2 Concentrations in the Cerebrospinal Fluid Correlate with the Severity of Neurofibrillary Degeneration, Cognitive Impairment, and Inflammasome Activation in Alzheimer’s Disease', Neurology International, 15(3), pp. 842-856. doi: 10.3390/neurolint15030053

Španić Popovački E, Babić Leko M, Langer Horvat L, Brgić K, Vogrinc Ž, Boban M, and sur.. Soluble TREM2 Concentrations in the Cerebrospinal Fluid Correlate with the Severity of Neurofibrillary Degeneration, Cognitive Impairment, and Inflammasome Activation in Alzheimer’s Disease. Neurology International [Internet]. 2023 July 07 [cited 2024 December 02];15(3):842-856. doi: 10.3390/neurolint15030053

E. Španić Popovački, et al., "Soluble TREM2 Concentrations in the Cerebrospinal Fluid Correlate with the Severity of Neurofibrillary Degeneration, Cognitive Impairment, and Inflammasome Activation in Alzheimer’s Disease", Neurology International, vol. 15, no. 3, pp. 842-856, July 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:664041. [Accessed: 02 December 2024]

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Title (english)Soluble TREM2 Concentrations in the Cerebrospinal Fluid Correlate with the Severity of Neurofibrillary Degeneration, Cognitive Impairment, and Inflammasome Activation in Alzheimer’s Disease
AuthorEna Španić Popovački
AuthorMirjana Babić Leko
AuthorLea Langer Horvat
AuthorKlara Brgić
AuthorŽeljka Vogrinc
AuthorMarina Boban
AuthorNataša Klepac
AuthorFran Borovečki
AuthorGoran Šimić
Author's institutionUniversity of Zagreb
School of Medicine
(Croatian Institiute for Brain Research)
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Neurology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Neurology
Abstract (english)
Background: Individuals with specific TREM2 gene variants that encode for a Triggering Receptor Expressed on Myeloid cells 2 have a higher prevalence of Alzheimer's disease (AD). By interacting with amyloid and apolipoproteins, the TREM2 receptor regulates the number of myeloid cells, phagocytosis, and the inflammatory response. Higher TREM2 expression has been suggested to protect against AD. However, it is extremely difficult to comprehend TREM2 signaling in the context of AD. Previous results are variable and show distinct effects on diverse pathological changes in AD, differences between soluble and membrane isoform signaling, and inconsistency between animal models and humans. In addition, the relationship between TREM2 and inflammasome activation pathways is not yet entirely understood. Objective: This study aimed to determine the relationship between soluble TREM2 (sTREM2) levels in cerebrospinal fluid (CSF) and plasma samples and other indicators of AD pathology. Methods: Using the Enzyme-Linked Immunosorbent Assay (ELISA), we analyzed 98 samples of AD plasma, 35 samples of plasma from individuals with mild cognitive impairment (MCI), and 11 samples of plasma from healthy controls (HC), as well as 155 samples of AD CSF, 90 samples of MCI CSF, and 50 samples of HC CSF. Results: CSF sTREM2 levels were significantly correlated with neurofibrillary degeneration, cognitive decline, and inflammasome activity in AD patients. In contrast to plasma sTREM2, CSF sTREM2 levels in the AD group were higher than those in the MCI and HC groups. Moreover, concentrations of sTREM2 in CSF were substantially higher in the MCI group than in the HC group, indicating that CSF sTREM2 levels could be used not only to distinguish between HC and AD patients but also as a biomarker to detect earlier changes in the MCI stage. Conclusions: The results indicate CSF sTREM2 levels reliably predict neurofibrillary degeneration, cognitive decline, and inflammasome activation, and also have a high diagnostic potential for distinguishing diseased from healthy individuals. To add sTREM2 to the list of required AD biomarkers, future studies will need to include a larger number of patients and utilize a standardized methodology.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleNeurology International
Numberingvol. 15, no. 3, pp. 842-856
e-ISSN2035-8377
DOIhttps://doi.org/10.3390/neurolint15030053
URN:NBNurn:nbn:hr:105:664041
Publication2023-07-07
ProjectNumber: IP-2019-04-3584
Title (croatian): Uloga krvno-moždane barijere, urođene imunosti i oligomerizacije tau proteina u patogenezi Alzheimerove bolesti
Title (english): Role of blood-brain barrier, innate immunity, and tau protein oligomerization in the pathogenesis of Alzheimer's disease
Acronym: ALZ-BBB-INNATETAU
Leader: Goran Šimić
Jurisdiction: Croatia
Funding stream: Research Projects
ProjectNumber: KK.01.1.1.01.0007
Title (croatian): Znanstveni centar izvrsnosti - eksperimentalna i klinička istraživanja hipoksijsko-ishemijskog oštećenja mozga u perinatalnoj i odrasloj dobi
Title (english): Scientific center of excellence - Experimental and clinical research of hypoxic-ischemic brain damage in perinatal and adulthood
Acronym: ZCI-NEURO
Leader: Miloš Judaš
Jurisdiction: eu
Funding stream: European Regional Development Fund
Document URLhttps://www.mdpi.com/2035-8377/15/3/53
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2024-09-24 09:32:06