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Scientific paper - Original scientific paper
Corticosteroid Dosing Level, Incidence and Profile of Bacterial Blood Stream Infections in Hospitalized COVID-19 Patients
Viruses, 16 (2024), 1; 86. https://doi.org/10.3390/v16010086
Papić, Ivan; Bistrović, Petra; Čikara, Tomislav; Bušić, Nikolina; Kereš, Tatjana; Ortner Hadžiabdić, Maja; Lucijanić, Marko

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Papić, I., Bistrović, P., Čikara, T., Bušić, N., Kereš, T., Ortner Hadžiabdić, M. & Lucijanić, M. (2024). Corticosteroid Dosing Level, Incidence and Profile of Bacterial Blood Stream Infections in Hospitalized COVID-19 Patients. Viruses, 16. (1). doi: 10.3390/v16010086

Papić, Ivan, et al. "Corticosteroid Dosing Level, Incidence and Profile of Bacterial Blood Stream Infections in Hospitalized COVID-19 Patients." Viruses, vol. 16, no. 1, 2024. https://doi.org/10.3390/v16010086

Papić, Ivan, Petra Bistrović, Tomislav Čikara, Nikolina Bušić, Tatjana Kereš, Maja Ortner Hadžiabdić and Marko Lucijanić. "Corticosteroid Dosing Level, Incidence and Profile of Bacterial Blood Stream Infections in Hospitalized COVID-19 Patients." Viruses 16, no. 1 (2024). https://doi.org/10.3390/v16010086

Papić, I., et al. (2024) 'Corticosteroid Dosing Level, Incidence and Profile of Bacterial Blood Stream Infections in Hospitalized COVID-19 Patients', Viruses, 16(1). doi: 10.3390/v16010086

Papić I, Bistrović P, Čikara T, Bušić N, Kereš T, Ortner Hadžiabdić M, and sur.. Corticosteroid Dosing Level, Incidence and Profile of Bacterial Blood Stream Infections in Hospitalized COVID-19 Patients. Viruses [Internet]. 2024 January 05 [cited 2024 December 03];16(1). doi: 10.3390/v16010086

I. Papić, et al., "Corticosteroid Dosing Level, Incidence and Profile of Bacterial Blood Stream Infections in Hospitalized COVID-19 Patients", Viruses, vol. 16, no. 1, January 2024. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:766042. [Accessed: 03 December 2024]

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Metadata
Title (english)Corticosteroid Dosing Level, Incidence and Profile of Bacterial Blood Stream Infections in Hospitalized COVID-19 Patients
AuthorIvan Papić
AuthorPetra Bistrović
AuthorTomislav Čikara
AuthorNikolina Bušić
AuthorTatjana Kereš
AuthorMaja Ortner Hadžiabdić
AuthorMarko Lucijanić
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
COVID-19 patients with severe or critical symptoms are often treated with corticosteroids, per contemporary guidelines. Due to their immunosuppressive and immunomodulatory properties, corticosteroids are associated with the development of superinfections. We aimed to retrospectively assess patterns of corticosteroid use and the profiles of bacterial blood stream infections associated with exposure to different dosing levels, in a cohort of 1558 real-life adult COVID-19 patients. A total of 1391 (89.3%) patients were treated with corticosteroids, with 710 (45.6%) patients receiving low, 539 (34.6%) high and 142 (9.1%) very high corticosteroid doses. Bacteremia developed in a total of 178 (11.4%) patients. The risk of bacteremia was of similar magnitude between the no and low-dose corticosteroid treatments (p = 0.352), whereas it progressively increased with high (OR 6.18, 95% CI (2.66–14.38), p < 0.001) and very high corticosteroid doses (OR 8.12, 95% CI (3.29–20.05), p < 0.001), compared to no corticosteroid treatment. These associations persisted after multivariate adjustments and were present independently of sex, comorbidity burden, and mechanical ventilation. The profiles of individual bacterial pathogens differed depending on the used corticosteroid doses. High and very high corticosteroid doses are frequently used for real-life COVID-19 patients with severe and critical clinical presentations and are associated with a higher risk of bacteremia independently of sex, comorbidity burden, and mechanical ventilation use.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleViruses
Numberingvol. 16, no. 1, 86
e-ISSN1999-4915
DOIhttps://doi.org/10.3390/v16010086
URN:NBNurn:nbn:hr:105:766042
Publication2024-01-05
Document URLhttps://www.mdpi.com/1999-4915/16/1/86
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2024-12-03 08:43:20