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Corticosteroid Dosing Level, Incidence and Profile of Bacterial Blood Stream Infections in Hospitalized COVID-19 Patients
Viruses, 16 (2024), 1; 86. https://doi.org/10.3390/v16010086
Papić, Ivan; Bistrović, Petra; Čikara, Tomislav; Bušić, Nikolina; Kereš, Tatjana; Ortner Hadžiabdić, Maja; Lucijanić, Marko

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Papić, I., Bistrović, P., Čikara, T., Bušić, N., Kereš, T., Ortner Hadžiabdić, M. i Lucijanić, M. (2024). Corticosteroid Dosing Level, Incidence and Profile of Bacterial Blood Stream Infections in Hospitalized COVID-19 Patients. Viruses, 16. (1). doi: 10.3390/v16010086

Papić, Ivan, et al. "Corticosteroid Dosing Level, Incidence and Profile of Bacterial Blood Stream Infections in Hospitalized COVID-19 Patients." Viruses, vol. 16, br. 1, 2024. https://doi.org/10.3390/v16010086

Papić, Ivan, Petra Bistrović, Tomislav Čikara, Nikolina Bušić, Tatjana Kereš, Maja Ortner Hadžiabdić i Marko Lucijanić. "Corticosteroid Dosing Level, Incidence and Profile of Bacterial Blood Stream Infections in Hospitalized COVID-19 Patients." Viruses 16, br. 1 (2024). https://doi.org/10.3390/v16010086

Papić, I., et al. (2024) 'Corticosteroid Dosing Level, Incidence and Profile of Bacterial Blood Stream Infections in Hospitalized COVID-19 Patients', Viruses, 16(1). doi: 10.3390/v16010086

Papić I, Bistrović P, Čikara T, Bušić N, Kereš T, Ortner Hadžiabdić M, i sur.. Corticosteroid Dosing Level, Incidence and Profile of Bacterial Blood Stream Infections in Hospitalized COVID-19 Patients. Viruses [Internet]. 05.01.2024. [pristupljeno 03.12.2024.];16(1). doi: 10.3390/v16010086

I. Papić, et al., "Corticosteroid Dosing Level, Incidence and Profile of Bacterial Blood Stream Infections in Hospitalized COVID-19 Patients", Viruses, vol. 16, br. 1, Siječanj 2024. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:766042. [Citirano: 03.12.2024.]

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Podaci o radu
Naslov (engleski)Corticosteroid Dosing Level, Incidence and Profile of Bacterial Blood Stream Infections in Hospitalized COVID-19 Patients
AutorIvan Papić
AutorPetra Bistrović
AutorTomislav Čikara
AutorNikolina Bušić
AutorTatjana Kereš
AutorMaja Ortner Hadžiabdić
AutorMarko Lucijanić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA INTERNU MEDICINU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak (engleski)
COVID-19 patients with severe or critical symptoms are often treated with corticosteroids, per contemporary guidelines. Due to their immunosuppressive and immunomodulatory properties, corticosteroids are associated with the development of superinfections. We aimed to retrospectively assess patterns of corticosteroid use and the profiles of bacterial blood stream infections associated with exposure to different dosing levels, in a cohort of 1558 real-life adult COVID-19 patients. A total of 1391 (89.3%) patients were treated with corticosteroids, with 710 (45.6%) patients receiving low, 539 (34.6%) high and 142 (9.1%) very high corticosteroid doses. Bacteremia developed in a total of 178 (11.4%) patients. The risk of bacteremia was of similar magnitude between the no and low-dose corticosteroid treatments (p = 0.352), whereas it progressively increased with high (OR 6.18, 95% CI (2.66–14.38), p < 0.001) and very high corticosteroid doses (OR 8.12, 95% CI (3.29–20.05), p < 0.001), compared to no corticosteroid treatment. These associations persisted after multivariate adjustments and were present independently of sex, comorbidity burden, and mechanical ventilation. The profiles of individual bacterial pathogens differed depending on the used corticosteroid doses. High and very high corticosteroid doses are frequently used for real-life COVID-19 patients with severe and critical clinical presentations and are associated with a higher risk of bacteremia independently of sex, comorbidity burden, and mechanical ventilation use.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaViruses
Brojčani podacivol. 16, br. 1, 86
e-ISSN1999-4915
DOIhttps://doi.org/10.3390/v16010086
URN:NBNurn:nbn:hr:105:766042
Datum objave publikacije2024-01-05
URL dokumentahttps://www.mdpi.com/1999-4915/16/1/86
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2024-12-03 08:43:20