Ekvivalent: Karcinom prostate s komponentom nalik na Panethove stanice - prikaz slučaja

professional thesis

• Title (english): Equivalent: Paneth cell-like component in prostate cancer - case report
• Author: Josip Šojat
• Mentor: Božo Krušlin (mentor)
• Granter: University of Zagreb; School of Medicine; Zagreb
• Defense date and country: 2024-11-25, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Pathology

Abstract

Adenokarcinom prostate s neuroendokrinom diferencijacijom u obliku komponente koja nalikuje Panethovim stanicama je vrlo rijedak entitet. Raspršene neuroendokrine stanice nalik Panethovima mogu se naći u većini opisanih slučajeva, iako se nalaze i primjeri s predominantnom komponentom navedenih stanica. One sadrže eozinofilne citoplazmatske inkluzije, a nedostaju im androgeni receptori te su stoga imuni na hormonsku terapiju, a što je jedan od glavnih razloga da ih patolozi prepoznaju. Prema dostupnoj literaturi, klinički ishod takvih tumora ovisi o standardnim parametrima, ponajprije o gradusu konvencionalne komponente karcinoma prostate. Ovdje opisujemo 54-godišnjeg bolesnika s adenokarcinomom prostate koji pokazuje neuroendokrinu diferencijaciju tipa stanica nalik Panethovim.

Abstract (english)

Prostate adenocarcinoma with Paneth cell-like neuroendocrine diff erentiation is a rare entity. Foci of scattered cells and small clusters are found in the majority of described cases, although cases with predominant Paneth cell-like features have also been recorded. Th ese cells contain eosinophilic cytoplasmic inclusions and lack androgen receptors, and are consequently immune to hormone therapy. It is, therefore, important for pathologists to recognize them. According to literature, clinical outcome depends on the standard grading of the conventional prostate cancer component. We report a case of a 54 year-old patient with prostatic adenocarcinoma showing Paneth celllike neuroendocrine diff erentiation

• Keywords: Prostata; Adenokarcinom; Panethove stanice
• Keywords (english): Prostate; Adenocarcinoma; Paneth cells
• Language: croatian
• URN:NBN: urn:nbn:hr:105:086473
• Study programme: Title: Pathology and cytology; Study programme type: university; Study level: postgraduate specialist; Academic / professional title: sveučilišni/a magistar/magistra patologije i citologije (sveučilišni/a magistar/magistra patologije i citologije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2025-01-13 12:19:06