Utjecaj tvrdoće vode i magnezija na pojavnost kardiovaskularnih bolesti

master's thesis

• Title (english): Association of cardiovascular disease risks with water hardness and magnesium
• Author: Željka Marković
• Mentor: Ankica Senta Marić (mentor)
• Committee member: Iskra Alexandra Nola (predsjednik povjerenstva)
• Committee member: Jagoda Doko Jelinić (član povjerenstva)
• Committee member: Ankica Senta Marić (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Environmental and Occupational Health); Zagreb
• Defense date and country: 2016-07-15, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Public Health and Health Care; Health Ecology

Abstract

Istraživanja sugeriraju na inverznu povezanost između tvrdoće vode, s posebnim naglaskom na sadržaj magnezija u vodi za piće, i smanjenja mortaliteta od kardiovaskularnih bolesti. Podzemna voda Grada Zagreba spada u tvrdu vodu. Gledajući globalno Hrvatska ima veću koncentraciju minerala u vodi za piće. Procesi kojima se regulira zdravstvena ispravnost vode za piće mogu pridonijeti nižim koncentracijama magnezija. Voda obogaćena magnezijem dovodi do povrata koncentracije serumskog magnezija na normalne vrijednosti. Magnezij iz vode je biološki dostupniji od magnezija iz hrane. Svjetska zdravstvena organizacija sugerira na dobrobit mineralnih voda kao nadomjestak za neadekvatan unos minerala putem hrane i pića. Mineralna voda bogata magnezijem se nalazi u smjernicama za dijabetičku prehranu i prehranu kod hipertenzije. Kohortne studije su pokazale da hipomagnezijemija dovodi do 66% većeg rizika za razvoj zatajenja srca i do 50% veće šanse razvoja atrijske fibrilacije. Deficit magnezija potiče funkciju neutralne sfingomijelinaze, 8-OhdG i inducira oksidativno oštećenje DNA što se posljedično povezuje s aterogenezom i kardiovaskularnim bolestima. Dokazano je da je deficit magnezija čest u općoj populaciji s obzirom na prehrambene navike suvremenog društva i nedostatan unos tekućine. Dugotrajno uzimanje inhibitora protonske pumpe inducira hipomagnezijemiju koja se prezentira kao supraventrikularna tahikardija. Diuretici koji se često koriste u kardiovaskularnim bolestima uzrokuju deficit magnezija. Preporuke za pacijente bi trebale uključiti dnevnu konzumaciju namirnica bogatih magnezijem poput badema i mineralnu vodu bogatu magnezijem.

Abstract (english)

Studies suggest inverse association between water hardness, specially water magnesium, and decreased cardiovascular mortality. Groundwater of Zagreb is classified as hard water. Croatia has water high in minerals, compared globally. The processes that regulate the health safety of drinking water can contribute to lower concentrations of magnesium. Water high in magnesium leads to the recovery of serum magnesium to normal. Waterborne magnesium is known to be more bioavailable than magnesium obtained from food. The World Health Organization suggests the benefit of mineral water as a substitute for inadequate intake of minerals through food and drinks. Mineral water high in magnesium is in the guidelines for diabetic diet and nutrition in hypertension. Cohort studies have shown that hypomagnesaemia leads to a 66% higher risk of developing heart failure and up to 50% greater chance of developing atrial fibrillation. Magnesium deficiency upregulates neutral sphingomyelinase, 8-OHdG and induces oxidative DNA damage which has relevance to atherogenesis and cardiovascular diseases. Magnesium deficiency is common among general population due to dietary habits of modern society and insufficient fluid intake. Long-term use of proton pump inhibitors induces hypomagnesaemia which is presented as supraventricular tachycardia. Diuretics, commonly used in cardiovascular diseases treatment lead to magnesium deficiency. A recommendation for patients should include daily consumption of dietary products rich in magnesium such as almonds and mineral water high in magnesium.

• Keywords: deficit magnezija; kardiovaskularne bolesti; mineralna voda bogata magnezijem
• Keywords (english): magnesium deficiency; cardiovascular diseases; mineral water high in magnesium
• Language: croatian
• URN:NBN: urn:nbn:hr:105:441301
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2017-08-18 08:59:16