Funkcionalna kirurgija kod karcinoma grkljana

master's thesis

• Title (english): Functional surgery of larynx carcinoma
• Author: Ivana Šarac
• Mentor: Drago Prgomet (mentor)
• Committee member: Mario Bilić (predsjednik povjerenstva)
• Committee member: Mirko Ivkić (član povjerenstva)
• Committee member: Drago Prgomet (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Othorhinolaryngology and Head and Neck Surgery); Zagreb
• Defense date and country: 2017-07-14, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Otorhinolaryngology

Abstract

Tumori glave i vrata postaju sve učestaliji u Republici Hrvatskoj. Prema podacima iz 2013. godine, ovi tumori čine gotovo 7% novodijagnosticiranih zloćudnih tumora kod muškaraca te 1,5% kod žena. Mnogo je rizičnih faktora koji se povezuju s karcinomima glave i vrata: pušenje, kronična konzumacija alkohola, humani papiloma virus, izloženost radijaciji, prethodna povijest karcinoma glave i vrata itd. Više od 90% novodijagnosticiranih laringealnih karcinoma su karcinomi pločastih stanica, koji se mogu razviti u bilo kojem dijelu larinksa. Većina ih je smještena u glotičkom području; supraglotičko i subglotičko sijelo su nešto manje zastupljeni. Laringealni karcinom se može proširiti direktnim širenjem u okolne bliske strukture, putem metastaza u regionalne limfne čvorove ili na udaljena mjesta putem krvi. Ovisno o lokaciji, stadiju bolesti i tipu karcinoma, postoje različite metode liječenja. Liječenje ovih pacijenata je kompleksno zbog iznimno bitnih funkcija ove anatomske regije. Glavni cilj liječenja je ukloniti tumor i prevenirati rekurenciju, ako je moguće, uz očuvanje laringealnih funkcija. Terapija se mijenjala kroz nekoliko zadnjih desetljeća jer je do 1990-ih terapija izbora bila kirurgija. Parcijalna i totalna laringektomija su bile i još su uvijek glavna kirurška opcija, ali danas na raspolaganju imamo i kemoradioterapiju. Nova otkrića u endoskopskoj kirurgiji i laserskoj opremi predstavljaju budućnost u kirurškom liječenju karcinoma larinksa.

Abstract (english)

Incidence of head and neck cancer in Croatia is continuously increasing. According to data from 2013, these tumors make up almost 7% of newly diagnosed malignant tumors in men and 1,5% in women. There are many risk factors associated with head and neck cancer such as smoking, chronic consumption of alcohol, human papillomavirus, irradiation exposure, previous history of head and neck cancer etc. More than 90% newly diagnosed laryngeal cancers are squamous cell carcinoma, which can develop in any part of the larynx. Most of them originate in the glottis; supraglottic and subglottic sites are less common. Laryngeal carcinoma may spread by direct extension to the nearby structures, by metastasis to regional lymph nodes or more distantly through blood. Depending on the location, staging and type of the tumor there are different methods of treatment. Treatment of patients with laryngeal carcinoma is complex because of the crucial functions of this anatomic area. If possible, the goal is to remove the tumor and prevent reccurrence while maintaining laryngeal function. Treatment has changed over the past few decades because until the 1990s the only option was surgery. Partial and total laryngectomies were and still are the main surgical procedures to treat this carcinoma, but today chemoradiotherapy is also available. In addition, new developments in endoscopic surgery and laser equipment are the future in the treatment of the malignant laryngeal carcinoma.

• Keywords: karcinom pločastih stanica; laringealni karcinom; kirurgija
• Keywords (english): squamous cell carcinoma; laryngeal cancer; surgery
• Language: croatian
• URN:NBN: urn:nbn:hr:105:011668
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2018-01-11 11:06:51