Pozitronska emisijska tomografija u dijagnostici limfoma

master's thesis

• Title (english): Positron emission tomography in diagnosis of lymphoma
• Author: Ivan Nikić
• Mentor: Dražen Huić (mentor)
• Committee member: Sanja Kusačić Kuna (predsjednik povjerenstva)
• Committee member: Maja Franceschi (član povjerenstva)
• Committee member: Dražen Huić (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Nuclear Medicine); Zagreb
• Defense date and country: 2017-07-14, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Nuclear Medicine
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Radiology
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Oncology

Abstract

Pozitronska emisijska tomografija (PET) predstavlja suvremenu funkcionalnu slikovnu metodu koja za vizualizaciju metabolizma različitih tkiva koristi razliku u nakupljanju radiofarmaka u pojedinim stanicama tkiva. Najčešće korišteni radiofarmak je fluordeoksiglukoza (FDG), analog glukoze obilježen radionuklidom fluor-18. Najvažniju kliničku primjenu nalazi u onkologiji, gdje koristi svojstvo stanica raka da zbog većeg iskorištenja glukoze u većim količinama nakupljaju glukozu od ostalih tkiva. PET slikovne metode osobito su važne u dijagnostici limfoma. Limfomi su heterogena skupina malignih bolesti s brojnim podtipovima, vrlo različitih kliničkih pojavnosti i karakterističnih nalaza slikovnih pregleda. PET integriran s računalnom tomografijom (PET/CT) združeno pruža funkcionalne i anatomske informacije i predstavlja vrlo osjetljivu i specifičnu dijagnostičku metodu. Koristi se u početnom određivanju proširenosti limfoma, planiranju liječenja, procjeni terapijskog učinka tijekom liječenja i po završetku liječenja te praćenju zbog ranog otkrivanja progresije ili recidiva bolesti, posebno u Hodgkinovim limfomima (HL) i difuznim velikostaničnim B-limfomima (DLBCL). PET združen s magnetskom rezonancijom (PET/MR) novija je slikovna metoda koja u odnosu na PET/CT otvara nove mogućnosti za evaluaciju tkivne strukture i metabolizma. PET/MR slikovne metode nude bolji prikaz mekih tkiva i mogu biti od koristi u procjeni ekstranodalne proširenosti limfoma. Budući da MR slikovne metode ne upotrebljavaju ionizirajuće zračenje, PET/MR metode s manjim izlaganjem zračenju od PET/CT-a pogodne su za primjenu u pedijatrijskih bolesnika ili u bolesnika koji se podvrgavaju višestrukim ciklusima pretraga zbog procjene odgovora na terapiju.

Abstract (english)

Positron emission tomography (PET) is a contemporary functional imaging method that allows for visualization of tissue metabolism by identifying differences in cellular radiopharmaceutical uptake. Commonly used radiopharmaceutical is fluorodeoxyglucose (FDG), a radioactive analog of glucose. The most significant clinical use of PET imaging is in oncology. PET imaging methods are particularly important in management of lymphoma, a heterogeneous group of malignant diseases with many subtypes, clinical manifestations and characteristic imaging findings. PET combined with computed tomography imaging (PET/CT) presents a highly sensitive and specific diagnostic method providing both metabolic and anatomical diagnostic information. PET/CT is utilized in initial staging of lymphoma, treatment planning, evaluation of treatment response and follow-up evaluation, mainly in Hodgkin’s lymphoma (HL) and diffuse large B-cell lymphoma (DLBCL). PET combined with magnetic resonance imaging (PET/MR) is a recent imaging method that provides new possibilities of tissue structure imaging and metabolism evaluation in comparison to PET/CT. PET/MR imaging methods allow for better soft tissue image quality and can be useful in evaluation of extranodal disease spread. Since PET/MR imaging methods do not use ionizing radiation, they are suitable for pediatric patients as well as patients undergoing multiple cycles of imaging diagnostic tests for evaluation of treatment response.

• Keywords: pozitronska emisijska tomografija; PET; limfom; PET/CT; PET/MR
• Keywords (english): positron emission tomography; PET; lymphoma; PET/CT; PET/MR
• Language: croatian
• URN:NBN: urn:nbn:hr:105:994167
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2018-03-20 10:33:43