TCD monitoriranje srednjih cerebralnih arterija tijekom izvođenja kognitivnih zadatak

master's thesis

• Title: TCD monitoriranje srednjih cerebralnih arterija tijekom izvođenja kognitivnih zadatak : usporedba dešnjaka i ljevaka
• Title (english): TCD monitoring of middle cerebral arteries during cognitive tasks performance : a comparison of right-handed and left-handed subjects
• Author: Jurica Vrbanec
• Mentor: Marina Boban (mentor)
• Committee member: Branko Malojčić (predsjednik povjerenstva)
• Committee member: Mario Habek (član povjerenstva)
• Committee member: Marina Boban (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Neurology); Zagreb
• Defense date and country: 2014-07-15, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Neurology

Abstract

Transkranijska Doppler ultrasonografija (TCD) je metoda koja omogućava procjenu lokalne aktivnosti moždanog tkiva mjerenjem brzina protoka krvi (BPK) u velikim krvnim žilama na bazi mozga. Promjene BPK u srednjim cerebralnim arterijama (MCA) odgovaraju aktivaciji i posljedičnoj vazodilataciji u mikrocirkulaciji određenih regija mozga opskrbljenih tom arterijom. Do sada nisu uspoređivane promjene BPK u ljevaka i dešnjaka kod izvođenja različitih kognitivnih zadataka. Ovo istraživanje uspoređuje BPK u MCA kod ljevaka i dešnjaka prilikom izvođenja testa verbalne fluentnosti (VFT) i Stroop testa s nekongruentnim podražajem. U ispitivanje je uključeno 12 mladih, zdravih dobrovoljaca, od toga 6 dešnjaka i 6 ljevaka. Ispitanicima su kroz transtemporalni koštani prostor praćene BPK kroz MCA pomoću TCD-a tijekom rješavanja kognitivnih zadataka. Nađeno je kako tijekom izvođenja VFT-a dolazi do jače statistički neznačajne lateralizacije protoka kod dešnjaka nego kod ljevaka što je u skladu s teorijom o manjoj lateralizaciji moždanih struktura kod ljevaka. Rezultati sugeriraju potencijal TCD-a kao dobre metode za procjenu funkcionalne anatomije uz jednostavnu i sigurnu primjenu.

Abstract (english)

Tcd monitoring of middle cerebral arteries during cognitive tasks performance – a comparison of right-handed and left-handed subjects Jurica Vrbanec Transcranial Doppler ultrasonography (TCD) is used for assesment of local brain tissue activity by monitoring blood flow velocities (BFVs) in basal cerebral arteries during different activity tasks. BFV changes in middle cerebral arteries (MCA) matches the activation and subsequent vasodilatation of microcirculation in different brain areas supplied by this artery. So far, little is known about BFV differences between right-handed and left-handed subject during different cognitive tasks performance. This research compares BFV changes in left- and right-handed subjects during the performance of verbal fluency test (VFT) and Stroop test with incongruent stimulus. 12 young, healthy volunteers, of which 6 are left- and 6 right-handed, were included in this study. BFVs in MCAs were monitored through transtemporal window using TCD during cognitive tasks performance. During the performance of VFT there was greater statisticaly nonsignificant lateralization in right-handed than in left-handed subjects, which is consistent with the fact that there is less lateralization in brain structures in left-handed subjects. Results also suggest potential use of TCD as a good method for assessment of functional brain anatomy, being very safe and easy to use at the same time.

• Keywords: transkranijski Doppler; srednja cerebralna arterija; brzina krvnog protoka; kognitivni zadaci; ljevaštvo; dešnjaštvo
• Keywords (english): Transcranial Doppler; Middle Cerebral Artery; Blood Flow Velocity; Cognitive tasks; Left-handed; Right-handed
• Language: croatian
• URN:NBN: urn:nbn:hr:105:666362
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2015-10-13 12:34:07