Metode liječenja žarišnih oštećenja hrskavice koljena

master's thesis

• Title (english): Treatment of focal knee cartilage lesions
• Author: Lovro Sočo
• Mentor: Mislav Jelić (mentor)
• Committee member: Tomislav Smoljanović (predsjednik povjerenstva)
• Committee member: Tomislav Đapić (član povjerenstva)
• Committee member: Mislav Jelić (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Orthopedics); Zagreb
• Defense date and country: 2019-07-12, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Orthopedics

Abstract

Kao najveći sinovijalni zglob u ljudskom tijelu koljeno ima veliku važnost u nošenju tjelesne težine te u kretanju. Uz njegovu veličinu također se ističe i njegova kompleksnost u građi jer se u njemu uzglobljavaju tri kosti: femur, tibija i fibula. U njegovoj biomehanici, izuzev kretnji fleksije i ekstenzije moguća je i rotacija u kombinaciji s opuštenim kolateralnim svezama. Kao i u ostalim zglobovima pokrov zglobnih tijela čini hijalina hrskavica koja uslijed traumi različite etiologije može biti fokalno oštećena. U novije doba ortopedi su prepoznali takva oštećenja kao početni stadij razvoja osteoartritisa koljena te mogućnost njihova saniranja u svrhu prevencije daljnjih oštećenja, kako u svrhu redukcije financijskih troškova tako i u svrhu povećanja kvalitete života pacijenata. Danas se koristi nekoliko metoda liječenja fokalnih oštećenja hrskavice koljena, ali niti jedna u potpunosti ne ispunjava idealistička očekivanja potpune regeneracije hrskavice. Autologna hondrocitna implantacija (ACI) je novija metoda koja je posljednjih godina stekla popularnost te je dosad pokazala obećavajuće rezultate. Usprkos tome, liječenje ove patologije i danas predstavlja velik izazov za ortopede, a uz napredak tehnologije doći će zasigurno do novih te usavršavanja postojećih metoda.

Abstract (english)

As the biggest synovial joint in the human body the knee is very important in carrying the body weight and for the motion. Beside its size, necessary to mention is, also, its complexity, because three bones are articulating in this joint: femur, tibia and fibula. In its biomechanics, except the movement of flexion and extension, rotation is, also possible with loosened collateral ligaments. As in the other joints the coverage of articular bodies is made out of hyaline cartilage which can be injured in trauma of different etiology. In the new era, orthopedic surgeons have recognized these types of injuries as the first stage of osteoarthritis of the knee and the importance of treating those, as well for the reduction of financial resources and, also for increasement of the quality of patient's lives. Today, some of methods for treating focal injuries of the knee cartilage are being used, but none of them completely fulfill the idealistic expectations of cartilage regeneration. Autologous chondrocyte implantation (ACI) is a newer method which has gained popularity and has shown promising results through past years. Despite of that, treating of this pathology still presents a great challenge for orthopedic surgeons, but with prosperity of new technology, surely new methods will be developed and the existing ones will be improved.

• Keywords: koljeno; hrskavica koljena; biomehanika; autologna hondrocitna implantacija; ACI
• Keywords (english): knee; knee cartilage; biomechanics; autologous chondrocyte implantation; ACI
• Language: croatian
• URN:NBN: urn:nbn:hr:105:105059
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Public note: Pohranitelj objekta unio ključne riječi.
• Created on: 2020-06-10 09:58:56