Remission of Recurrent Cochlear Hydrops Associated With Bromocriptine Treatment for Macroprolactinoma

Scientific paper - Case study

• Author: Andro Košec
• Author: Ivan Kruljac
• Author: Jakov Ajduk
• Author's institution: University of Zagreb; School of Medicine; (Department of Othorhinolaryngology and Head and Neck Surgery)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Otorhinolaryngology

Abstract (english)

Objective Current recommendations for cochlear hydrops treatment include systemic glucocorticoids and diuretics. Cochlear cells express dopamine receptors, although their role is unknown in the pathophysiology of cochlear hydrops. Case Description We report the case of remission of recurrent right-sided cochlear hydrops in a young male patient treated with bromocriptine due to pituitary macroprolactinoma. Transient improvement was observed after oral steroid and diuretic treatment, but cochlear hydrops recurred until the dose of bromocriptine was increased to 10 mg daily. Conclusion Bromocriptine may stimulate dopamine receptors in cochlear cells with potential therapeutic role in patients with cochlear hydrops. There are no widely accepted and effective treatments for endolymphatic hydrops, and identifying potential new and efficacious therapeutics is of high relevance.

• Keywords (english): Adult; Audiometry, Pure-Tone; Bromocriptine / therapeutic use; Cochlear Diseases / complications; Cochlear Diseases / drug therapy; Diuretics / therapeutic use; Furosemide / therapeutic use; Glucocorticoids / therapeutic use; Hearing Loss, Sensorineural / complications; Hearing Loss, Sensorineural / drug therapy; Hormone Antagonists / therapeutic use; Humans; Magnetic Resonance Imaging; Male; Methylprednisolone / therapeutic use; Pituitary Neoplasms / complications; Pituitary Neoplasms / diagnostic imaging; Pituitary Neoplasms / drug therapy; Pituitary Neoplasms / pathology; Prolactinoma / complications; Prolactinoma / diagnostic imaging; Prolactinoma / drug therapy; Prolactinoma / pathology; Recurrence
• Language: english
• Publication type: Scientific paper - Case study
• Publication status: Published
• Peer review: Peer review
• Publication version: Accepted version
• Journal title: American Journal of Audiology
• Numbering: vol. 28, no. 3, pp. 548-552
• p-ISSN: 1059-0889
• e-ISSN: 1558-9137
• DOI: https://doi.org/10.1044/2019_AJA-18-0191
• URN:NBN: urn:nbn:hr:105:163210
• Publication: 2019-09-13
• Document URL: http://pubs.asha.org/doi/10.1044/2019_AJA-18-0191
• Type of resource: Text
• Access conditions: Open access
• Created on: 2021-01-21 10:31:47