Remission of Recurrent Cochlear Hydrops Associated With Bromocriptine Treatment for Macroprolactinoma

Znanstveni rad - Prikaz slučaja

• Autor: Andro Košec
• Autor: Ivan Kruljac
• Autor: Jakov Ajduk
• Autorova ustanova: Sveučilište u Zagrebu; Medicinski fakultet; (KATEDRA ZA OTORINOLARINGOLOGIJU I KIRURGIJU GLAVE I VRATA)
• Znanstveno / umjetničko područje, polje i grana: BIOMEDICINA I ZDRAVSTVO; Kliničke medicinske znanosti; Otorinolaringologija

Sažetak (engleski)

Objective Current recommendations for cochlear hydrops treatment include systemic glucocorticoids and diuretics. Cochlear cells express dopamine receptors, although their role is unknown in the pathophysiology of cochlear hydrops. Case Description We report the case of remission of recurrent right-sided cochlear hydrops in a young male patient treated with bromocriptine due to pituitary macroprolactinoma. Transient improvement was observed after oral steroid and diuretic treatment, but cochlear hydrops recurred until the dose of bromocriptine was increased to 10 mg daily. Conclusion Bromocriptine may stimulate dopamine receptors in cochlear cells with potential therapeutic role in patients with cochlear hydrops. There are no widely accepted and effective treatments for endolymphatic hydrops, and identifying potential new and efficacious therapeutics is of high relevance.

• Ključne riječi (engleski): Adult; Audiometry, Pure-Tone; Bromocriptine / therapeutic use; Cochlear Diseases / complications; Cochlear Diseases / drug therapy; Diuretics / therapeutic use; Furosemide / therapeutic use; Glucocorticoids / therapeutic use; Hearing Loss, Sensorineural / complications; Hearing Loss, Sensorineural / drug therapy; Hormone Antagonists / therapeutic use; Humans; Magnetic Resonance Imaging; Male; Methylprednisolone / therapeutic use; Pituitary Neoplasms / complications; Pituitary Neoplasms / diagnostic imaging; Pituitary Neoplasms / drug therapy; Pituitary Neoplasms / pathology; Prolactinoma / complications; Prolactinoma / diagnostic imaging; Prolactinoma / drug therapy; Prolactinoma / pathology; Recurrence
• Jezik: engleski
• Vrsta publikacije: Znanstveni rad - Prikaz slučaja
• Status objave: Objavljen
• Vrsta recenzije: Recenziran
• Verzija publikacije: Završna verzija rukopisa prihvaćena za objavljivanje (postprint)
• Naslov časopisa: American Journal of Audiology
• Brojčani podaci: vol. 28, br. 3, str. 548-552
• p-ISSN: 1059-0889
• e-ISSN: 1558-9137
• DOI: https://doi.org/10.1044/2019_AJA-18-0191
• URN:NBN: urn:nbn:hr:105:163210
• Datum objave publikacije: 2019-09-13
• URL dokumenta: http://pubs.asha.org/doi/10.1044/2019_AJA-18-0191
• Vrsta resursa: Tekst
• Prava pristupa: Otvoreni pristup
• Datum i vrijeme pohrane: 2021-01-21 10:31:47