Identification of 22 susceptibility loci associated with testicular germ cell tumors

Pluta, John; Pyle, Louise C.; Nead, Kevin T.; Wilf, Rona; Li, Mingyao; Mitra, Nandita; Weathers, Benita; D’Andrea, Kurt; Almstrup, Kristian; Anson-Cartwright, Lynn; Benitez, Javier; Brown, Christopher D.; Chanock, Stephen; Chen, Chu; Cortessis, Victoria K.; Ferlin, Alberto; Foresta, Carlo; Gamulin, Marija; Gietema, Jourik A.; Grasso, Chiara; Greene, Mark H.; Grotmol, Tom; Hamilton, Robert J.; Haugen, Trine B.; Hauser, Russ; Hildebrandt, Michelle A. T.; Johnson, Matthew E.; Karlsson, Robert; Kiemeney, Lambertus A.; Lessel, Davor; Lothe, Ragnhild A.; Loud, Jennifer T.; Loveday, Chey; Martin-Gimeno, Paloma; Meijer, Coby; Nsengimana, Jérémie; Quinn, David I.; Rafnar, Thorunn; Ramdas, Shweta; Richiardi, Lorenzo; Skotheim, Rolf I.; Stefansson, Kari; Turnbull, Clare; Vaughn, David J.; Wiklund, Fredrik; Wu, Xifeng; Yang, Daphne; Zheng, Tongzhang; Wells, Andrew D.; Grant, Struan F. A.; Rajpert-De Meyts, Ewa; Schwartz, Stephen M.; Bishop, D. Timothy; McGlynn, Katherine A.; Kanetsky, Peter A.; Nathanson, Katherine L.; Kubisch, Christian

doi:10.1038/s41467-021-24334-y

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Scientific paper - Original scientific paper

Identification of 22 susceptibility loci associated with testicular germ cell tumors

Nature Communications, 12 (2021), 1; 4487. https://doi.org/10.1038/s41467-021-24334-y

(Testicular Cancer Consortium) Pluta, John; Pyle, Louise C.; Nead, Kevin T.; Wilf, Rona; Li, Mingyao; Mitra, Nandita; Weathers, Benita; D’Andrea, Kurt; Almstrup, Kristian; Anson-Cartwright, Lynn; Benitez, Javier; Brown, Christopher D.; Chanock, Stephen; Chen, Chu; Cortessis, Victoria K.; Ferlin, Alberto; Foresta, Carlo; Gamulin, Marija; Gietema, Jourik A.; Grasso, Chiara; Greene, Mark H.; Grotmol, Tom; Hamilton, Robert J.; Haugen, Trine B.; Hauser, Russ; Hildebrandt, Michelle A. T.; Johnson, Matthew E.; Karlsson, Robert; Kiemeney, Lambertus A.; Lessel, Davor; Lothe, Ragnhild A.; Loud, Jennifer T.; Loveday, Chey; Martin-Gimeno, Paloma; Meijer, Coby; Nsengimana, Jérémie; Quinn, David I.; Rafnar, Thorunn; Ramdas, Shweta; Richiardi, Lorenzo; Skotheim, Rolf I.; Stefansson, Kari; Turnbull, Clare; Vaughn, David J.; Wiklund, Fredrik; Wu, Xifeng; Yang, Daphne; Zheng, Tongzhang; Wells, Andrew D.; Grant, Struan F. A.; Rajpert-De Meyts, Ewa; Schwartz, Stephen M.; Bishop, D. Timothy; McGlynn, Katherine A.; Kanetsky, Peter A.; Nathanson, Katherine L.; Kubisch, Christian More authors...

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APA 6th Edition

Pluta, J., Pyle, L. C., Nead, K. T., Wilf, R., Li, M., Mitra, N. ... Kubisch, C. (2021). Identification of 22 susceptibility loci associated with testicular germ cell tumors. Nature Communications, 12. (1). doi: 10.1038/s41467-021-24334-y

MLA 8th Edition

Pluta, John, et al. "Identification of 22 susceptibility loci associated with testicular germ cell tumors." Nature Communications, vol. 12, no. 1, 2021. https://doi.org/10.1038/s41467-021-24334-y

Chicago 17th Edition

Pluta, John, Louise C. Pyle, Kevin T. Nead, Rona Wilf, Mingyao Li, Nandita Mitra, Benita Weathers, et al. "Identification of 22 susceptibility loci associated with testicular germ cell tumors." Nature Communications 12, no. 1 (2021). https://doi.org/10.1038/s41467-021-24334-y

Harvard

Pluta, J., et al. (2021) 'Identification of 22 susceptibility loci associated with testicular germ cell tumors', Nature Communications, 12(1). doi: 10.1038/s41467-021-24334-y

Vancouver

Pluta J, Pyle LC, Nead KT, Wilf R, Li M, Mitra N, and sur.. Identification of 22 susceptibility loci associated with testicular germ cell tumors. Nature Communications [Internet]. 2021 July 23 [cited 2024 August 18];12(1). doi: 10.1038/s41467-021-24334-y

IEEE

J. Pluta, et al., "Identification of 22 susceptibility loci associated with testicular germ cell tumors", Nature Communications, vol. 12, no. 1, July 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:752009. [Accessed: 18 August 2024]

Cite this item: https://urn.nsk.hr/urn:nbn:hr:105:752009

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Metadata

Title (english)	Identification of 22 susceptibility loci associated with testicular germ cell tumors
Author	John Pluta
Author	Louise C. Pyle
Author	Kevin T. Nead
Author	Rona Wilf
Author	Mingyao Li
Author	Nandita Mitra
Author	Benita Weathers
Author	Kurt D’Andrea
Author	Kristian Almstrup
Author	Lynn Anson-Cartwright
Author	Javier Benitez
Author	Christopher D. Brown
Author	Stephen Chanock
Author	Chu Chen
Author	Victoria K. Cortessis
Author	Alberto Ferlin
Author	Carlo Foresta
Author	Marija Gamulin
Author	Jourik A. Gietema
Author	Chiara Grasso
Author	Mark H. Greene
Author	Tom Grotmol
Author	Robert J. Hamilton
Author	Trine B. Haugen
Author	Russ Hauser
Author	Michelle A. T. Hildebrandt
Author	Matthew E. Johnson
Author	Robert Karlsson
Author	Lambertus A. Kiemeney
Author	Davor Lessel
Author	Ragnhild A. Lothe
Author	Jennifer T. Loud
Author	Chey Loveday
Author	Paloma Martin-Gimeno
Author	Coby Meijer
Author	Jérémie Nsengimana
Author	David I. Quinn
Author	Thorunn Rafnar
Author	Shweta Ramdas
Author	Lorenzo Richiardi
Author	Rolf I. Skotheim
Author	Kari Stefansson
Author	Clare Turnbull
Author	David J. Vaughn
Author	Fredrik Wiklund
Author	Xifeng Wu
Author	Daphne Yang
Author	Tongzhang Zheng
Author	Andrew D. Wells
Author	Struan F. A. Grant
Author	Ewa Rajpert-De Meyts
Author	Stephen M. Schwartz
Author	D. Timothy Bishop
Author	Katherine A. McGlynn
Author	Peter A. Kanetsky
Author	Katherine L. Nathanson
Author	Christian Kubisch
Collaboration	Testicular Cancer Consortium
Author's institution	University of Zagreb School of Medicine (Department of Clinical Oncology)
Scientific / art field, discipline and subdiscipline	BIOMEDICINE AND HEALTHCARE Clinical Medical Sciences Oncology
Abstract (english)	Testicular germ cell tumors (TGCT) are the most common tumor in young white men and have a high heritability. In this study, the international Testicular Cancer Consortium assemble 10,156 and 179,683 men with and without TGCT, respectively, for a genome-wide association study. This meta-analysis identifies 22 TGCT susceptibility loci, bringing the total to 78, which account for 44% of disease heritability. Men with a polygenic risk score (PRS) in the 95th percentile have a 6.8-fold increased risk of TGCT compared to men with median scores. Among men with independent TGCT risk factors such as cryptorchidism, the PRS may guide screening decisions with the goal of reducing treatment-related complications causing long-term morbidity in survivors. These findings emphasize the interconnected nature of two known pathways that promote TGCT susceptibility: male germ cell development within its somatic niche and regulation of chromosomal division and structure, and implicate an additional biological pathway, mRNA translation.
Keywords (english)
Language	english
Publication type	Scientific paper - Original scientific paper
Publication status	Published
Peer review	Peer review
Publication version	Published version
Journal title	Nature Communications
Numbering	vol. 12, no. 1, 4487
e-ISSN	2041-1723
DOI	https://doi.org/10.1038/s41467-021-24334-y
URN:NBN	urn:nbn:hr:105:752009
Publication	2021-07-23
Document URL	http://www.nature.com/articles/s41467-021-24334-y
Type of resource	Text
Access conditions	Open access
Terms of use
Created on	2022-06-06 07:36:41