prikaz prve stranice dokumenta Identification of 22 susceptibility loci associated with testicular germ cell tumors
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Identification of 22 susceptibility loci associated with testicular germ cell tumors
Nature Communications, 12 (2021), 1; 4487. https://doi.org/10.1038/s41467-021-24334-y
(Testicular Cancer Consortium) Pluta, John; Pyle, Louise C.; Nead, Kevin T.; Wilf, Rona; Li, Mingyao; Mitra, Nandita; Weathers, Benita; D’Andrea, Kurt; Almstrup, Kristian; Anson-Cartwright, Lynn; Benitez, Javier; Brown, Christopher D.; Chanock, Stephen; Chen, Chu; Cortessis, Victoria K.; Ferlin, Alberto; Foresta, Carlo; Gamulin, Marija; Gietema, Jourik A.; Grasso, Chiara; Greene, Mark H.; Grotmol, Tom; Hamilton, Robert J.; Haugen, Trine B.; Hauser, Russ; Hildebrandt, Michelle A. T.; Johnson, Matthew E.; Karlsson, Robert; Kiemeney, Lambertus A.; Lessel, Davor; Lothe, Ragnhild A.; Loud, Jennifer T.; Loveday, Chey; Martin-Gimeno, Paloma; Meijer, Coby; Nsengimana, Jérémie; Quinn, David I.; Rafnar, Thorunn; Ramdas, Shweta; Richiardi, Lorenzo; Skotheim, Rolf I.; Stefansson, Kari; Turnbull, Clare; Vaughn, David J.; Wiklund, Fredrik; Wu, Xifeng; Yang, Daphne; Zheng, Tongzhang; Wells, Andrew D.; Grant, Struan F. A.; Rajpert-De Meyts, Ewa; Schwartz, Stephen M.; Bishop, D. Timothy; McGlynn, Katherine A.; Kanetsky, Peter A.; Nathanson, Katherine L.; Kubisch, Christian Više autora...

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Pluta, J., Pyle, L. C., Nead, K. T., Wilf, R., Li, M., Mitra, N. ... Kubisch, C. (2021). Identification of 22 susceptibility loci associated with testicular germ cell tumors. Nature Communications, 12. (1). doi: 10.1038/s41467-021-24334-y

Pluta, John, et al. "Identification of 22 susceptibility loci associated with testicular germ cell tumors." Nature Communications, vol. 12, br. 1, 2021. https://doi.org/10.1038/s41467-021-24334-y

Pluta, John, Louise C. Pyle, Kevin T. Nead, Rona Wilf, Mingyao Li, Nandita Mitra, Benita Weathers, et al. "Identification of 22 susceptibility loci associated with testicular germ cell tumors." Nature Communications 12, br. 1 (2021). https://doi.org/10.1038/s41467-021-24334-y

Pluta, J., et al. (2021) 'Identification of 22 susceptibility loci associated with testicular germ cell tumors', Nature Communications, 12(1). doi: 10.1038/s41467-021-24334-y

Pluta J, Pyle LC, Nead KT, Wilf R, Li M, Mitra N, i sur.. Identification of 22 susceptibility loci associated with testicular germ cell tumors. Nature Communications [Internet]. 23.07.2021. [pristupljeno 13.10.2024.];12(1). doi: 10.1038/s41467-021-24334-y

J. Pluta, et al., "Identification of 22 susceptibility loci associated with testicular germ cell tumors", Nature Communications, vol. 12, br. 1, Srpanj 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:752009. [Citirano: 13.10.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:752009
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Naslov (engleski)Identification of 22 susceptibility loci associated with testicular germ cell tumors
AutorJohn Pluta
AutorLouise C. Pyle
AutorKevin T. Nead
AutorRona Wilf
AutorMingyao Li
AutorNandita Mitra
AutorBenita Weathers
AutorKurt D’Andrea
AutorKristian Almstrup
AutorLynn Anson-Cartwright
AutorJavier Benitez
AutorChristopher D. Brown
AutorStephen Chanock
AutorChu Chen
AutorVictoria K. Cortessis
AutorAlberto Ferlin
AutorCarlo Foresta
AutorMarija Gamulin
AutorJourik A. Gietema
AutorChiara Grasso
AutorMark H. Greene
AutorTom Grotmol
AutorRobert J. Hamilton
AutorTrine B. Haugen
AutorRuss Hauser
AutorMichelle A. T. Hildebrandt
AutorMatthew E. Johnson
AutorRobert Karlsson
AutorLambertus A. Kiemeney
AutorDavor Lessel
AutorRagnhild A. Lothe
AutorJennifer T. Loud
AutorChey Loveday
AutorPaloma Martin-Gimeno
AutorCoby Meijer
AutorJérémie Nsengimana
AutorDavid I. Quinn
AutorThorunn Rafnar
AutorShweta Ramdas
AutorLorenzo Richiardi
AutorRolf I. Skotheim
AutorKari Stefansson
AutorClare Turnbull
AutorDavid J. Vaughn
AutorFredrik Wiklund
AutorXifeng Wu
AutorDaphne Yang
AutorTongzhang Zheng
AutorAndrew D. Wells
AutorStruan F. A. Grant
AutorEwa Rajpert-De Meyts
AutorStephen M. Schwartz
AutorD. Timothy Bishop
AutorKatherine A. McGlynn
AutorPeter A. Kanetsky
AutorKatherine L. Nathanson
AutorChristian Kubisch
KolaboracijaTesticular Cancer Consortium
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA KLINIČKU ONKOLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Onkologija
Sažetak (engleski)
Testicular germ cell tumors (TGCT) are the most common tumor in young white men and have a high heritability. In this study, the international Testicular Cancer Consortium assemble 10,156 and 179,683 men with and without TGCT, respectively, for a genome-wide association study. This meta-analysis identifies 22 TGCT susceptibility loci, bringing the total to 78, which account for 44% of disease heritability. Men with a polygenic risk score (PRS) in the 95th percentile have a 6.8-fold increased risk of TGCT compared to men with median scores. Among men with independent TGCT risk factors such as cryptorchidism, the PRS may guide screening decisions with the goal of reducing treatment-related complications causing long-term morbidity in survivors. These findings emphasize the interconnected nature of two known pathways that promote TGCT susceptibility: male germ cell development within its somatic niche and regulation of chromosomal division and structure, and implicate an additional biological pathway, mRNA translation.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaNature Communications
Brojčani podacivol. 12, br. 1, 4487
e-ISSN2041-1723
DOIhttps://doi.org/10.1038/s41467-021-24334-y
URN:NBNurn:nbn:hr:105:752009
Datum objave publikacije2021-07-23
URL dokumentahttp://www.nature.com/articles/s41467-021-24334-y
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2022-06-06 07:36:41