prikaz prve stranice dokumenta Liposomal Encapsulation Increases the Efficacy of Azithromycin against Chlamydia trachomatis
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Scientific paper - Original scientific paper
Liposomal Encapsulation Increases the Efficacy of Azithromycin against Chlamydia trachomatis
Pharmaceutics, 14 (2021), 1; 36. https://doi.org/10.3390/pharmaceutics14010036
Bogdanov, Anita; Janovák, László; Vraneš, Jasmina; Meštrović, Tomislav; Ljubin-Sternak, Sunčanica; Cseh, Zsuzsanna; Endrész, Valéria; Burián, Katalin; Vanić, Željka; Virok, Dezső P.

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Bogdanov, A., Janovák, L., Vraneš, J., Meštrović, T., Ljubin Sternak, S., Cseh, Z. ... Virok, D. P. (2021). Liposomal Encapsulation Increases the Efficacy of Azithromycin against Chlamydia trachomatis. Pharmaceutics, 14. (1). doi: 10.3390/pharmaceutics14010036

Bogdanov, Anita, et al. "Liposomal Encapsulation Increases the Efficacy of Azithromycin against Chlamydia trachomatis." Pharmaceutics, vol. 14, no. 1, 2021. https://doi.org/10.3390/pharmaceutics14010036

Bogdanov, Anita, László Janovák, Jasmina Vraneš, Tomislav Meštrović, Sunčanica Ljubin Sternak, Zsuzsanna Cseh, Valéria Endrész, Katalin Burián, Željka Vanić and Dezső P. Virok. "Liposomal Encapsulation Increases the Efficacy of Azithromycin against Chlamydia trachomatis." Pharmaceutics 14, no. 1 (2021). https://doi.org/10.3390/pharmaceutics14010036

Bogdanov, A., et al. (2021) 'Liposomal Encapsulation Increases the Efficacy of Azithromycin against Chlamydia trachomatis', Pharmaceutics, 14(1). doi: 10.3390/pharmaceutics14010036

Bogdanov A, Janovák L, Vraneš J, Meštrović T, Ljubin Sternak S, Cseh Z, and sur.. Liposomal Encapsulation Increases the Efficacy of Azithromycin against Chlamydia trachomatis. Pharmaceutics [Internet]. 2021 December 24 [cited 2024 October 05];14(1). doi: 10.3390/pharmaceutics14010036

A. Bogdanov, et al., "Liposomal Encapsulation Increases the Efficacy of Azithromycin against Chlamydia trachomatis", Pharmaceutics, vol. 14, no. 1, December 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:603221. [Accessed: 05 October 2024]

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Metadata
Title (english)Liposomal Encapsulation Increases the Efficacy of Azithromycin against Chlamydia trachomatis
AuthorAnita Bogdanov
AuthorLászló Janovák
AuthorJasmina Vraneš
AuthorTomislav Meštrović
AuthorSunčanica Ljubin-Sternak
AuthorZsuzsanna Cseh
AuthorValéria Endrész
AuthorKatalin Burián
AuthorŽeljka Vanić
AuthorDezső P. Virok
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Medical Microbiology and Parasitology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Medical Microbiology
Abstract (english)
Chlamydia trachomatis (C. trachomatis) is an obligate intracellular bacterium linked to ocular and urogenital infections with potentially serious sequelae, including blindness and infertility. First-line antibiotics, such as azithromycin (AZT) and doxycycline, are effective, but treatment failures have also been reported. Encapsulation of antibiotics in liposomes is considered an effective approach for improving their local effects, bioavailability, biocompatibility and antimicrobial activity. To test whether liposomes could enhance the antichlamydial action of AZT, we encapsulated AZT in different surface-charged elastic liposomes (neutral, cationic and anionic elastic liposomes) and assessed their antibacterial potential against the C. trachomatis serovar D laboratory strain as well as the clinical isolate C. trachomatis serovar F. A direct quantitative polymerase chain reaction (qPCR) method was used to measure chlamydial genome content 48 h post infection and to determine the recoverable chlamydial growth. All the liposomes efficiently delivered AZT to HeLa 229 cells infected with the laboratory Chlamydia strain, exhibiting the minimal inhibitory concentrations (MIC) and the minimal bactericidal concentrations (MBC) of AZT even 4–8-fold lower than those achieved with the free AZT. The tested AZT-liposomes were also effective against the clinical Chlamydia strain by decreasing MIC values by 2-fold relative to the free AZT. Interestingly, the neutral AZT-liposomes had no effect on the MBC against the clinical strain, while cationic and anionic AZT-liposomes decreased the MBC 2-fold, hence proving the potential of the surface-charged elastic liposomes to improve the effectiveness of AZT against C. trachomatis.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titlePharmaceutics
Numberingvol. 14, no. 1, 36
e-ISSN1999-4923
DOIhttps://doi.org/10.3390/pharmaceutics14010036
URN:NBNurn:nbn:hr:105:603221
Publication2021-12-24
Document URLhttps://www.mdpi.com/1999-4923/14/1/36
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2022-06-30 07:49:46