prikaz prve stranice dokumenta Liposomal Encapsulation Increases the Efficacy of Azithromycin against Chlamydia trachomatis
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Liposomal Encapsulation Increases the Efficacy of Azithromycin against Chlamydia trachomatis
Pharmaceutics, 14 (2021), 1; 36. https://doi.org/10.3390/pharmaceutics14010036
Bogdanov, Anita; Janovák, László; Vraneš, Jasmina; Meštrović, Tomislav; Ljubin-Sternak, Sunčanica; Cseh, Zsuzsanna; Endrész, Valéria; Burián, Katalin; Vanić, Željka; Virok, Dezső P.

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Bogdanov, A., Janovák, L., Vraneš, J., Meštrović, T., Ljubin Sternak, S., Cseh, Z. ... Virok, D. P. (2021). Liposomal Encapsulation Increases the Efficacy of Azithromycin against Chlamydia trachomatis. Pharmaceutics, 14. (1). doi: 10.3390/pharmaceutics14010036

Bogdanov, Anita, et al. "Liposomal Encapsulation Increases the Efficacy of Azithromycin against Chlamydia trachomatis." Pharmaceutics, vol. 14, br. 1, 2021. https://doi.org/10.3390/pharmaceutics14010036

Bogdanov, Anita, László Janovák, Jasmina Vraneš, Tomislav Meštrović, Sunčanica Ljubin Sternak, Zsuzsanna Cseh, Valéria Endrész, Katalin Burián, Željka Vanić i Dezső P. Virok. "Liposomal Encapsulation Increases the Efficacy of Azithromycin against Chlamydia trachomatis." Pharmaceutics 14, br. 1 (2021). https://doi.org/10.3390/pharmaceutics14010036

Bogdanov, A., et al. (2021) 'Liposomal Encapsulation Increases the Efficacy of Azithromycin against Chlamydia trachomatis', Pharmaceutics, 14(1). doi: 10.3390/pharmaceutics14010036

Bogdanov A, Janovák L, Vraneš J, Meštrović T, Ljubin Sternak S, Cseh Z, i sur.. Liposomal Encapsulation Increases the Efficacy of Azithromycin against Chlamydia trachomatis. Pharmaceutics [Internet]. 24.12.2021. [pristupljeno 05.10.2024.];14(1). doi: 10.3390/pharmaceutics14010036

A. Bogdanov, et al., "Liposomal Encapsulation Increases the Efficacy of Azithromycin against Chlamydia trachomatis", Pharmaceutics, vol. 14, br. 1, Prosinac 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:603221. [Citirano: 05.10.2024.]

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Naslov (engleski)Liposomal Encapsulation Increases the Efficacy of Azithromycin against Chlamydia trachomatis
AutorAnita Bogdanov
AutorLászló Janovák
AutorJasmina Vraneš
AutorTomislav Meštrović
AutorSunčanica Ljubin-Sternak
AutorZsuzsanna Cseh
AutorValéria Endrész
AutorKatalin Burián
AutorŽeljka Vanić
AutorDezső P. Virok
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA MEDICINSKU MIKROBIOLOGIJU I PARAZITOLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Medicinska mikrobiologija
Sažetak (engleski)
Chlamydia trachomatis (C. trachomatis) is an obligate intracellular bacterium linked to ocular and urogenital infections with potentially serious sequelae, including blindness and infertility. First-line antibiotics, such as azithromycin (AZT) and doxycycline, are effective, but treatment failures have also been reported. Encapsulation of antibiotics in liposomes is considered an effective approach for improving their local effects, bioavailability, biocompatibility and antimicrobial activity. To test whether liposomes could enhance the antichlamydial action of AZT, we encapsulated AZT in different surface-charged elastic liposomes (neutral, cationic and anionic elastic liposomes) and assessed their antibacterial potential against the C. trachomatis serovar D laboratory strain as well as the clinical isolate C. trachomatis serovar F. A direct quantitative polymerase chain reaction (qPCR) method was used to measure chlamydial genome content 48 h post infection and to determine the recoverable chlamydial growth. All the liposomes efficiently delivered AZT to HeLa 229 cells infected with the laboratory Chlamydia strain, exhibiting the minimal inhibitory concentrations (MIC) and the minimal bactericidal concentrations (MBC) of AZT even 4–8-fold lower than those achieved with the free AZT. The tested AZT-liposomes were also effective against the clinical Chlamydia strain by decreasing MIC values by 2-fold relative to the free AZT. Interestingly, the neutral AZT-liposomes had no effect on the MBC against the clinical strain, while cationic and anionic AZT-liposomes decreased the MBC 2-fold, hence proving the potential of the surface-charged elastic liposomes to improve the effectiveness of AZT against C. trachomatis.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaPharmaceutics
Brojčani podacivol. 14, br. 1, 36
e-ISSN1999-4923
DOIhttps://doi.org/10.3390/pharmaceutics14010036
URN:NBNurn:nbn:hr:105:603221
Datum objave publikacije2021-12-24
URL dokumentahttps://www.mdpi.com/1999-4923/14/1/36
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2022-06-30 07:49:46