Maligni tumori orofarinksa

master's thesis

• Title (english): Oropharyngeal malignant tumors
• Author: Ružica Potkrajčić
• Mentor: Vesna Bišof (mentor)
• Committee member: Maja Sirotković Skerlev (predsjednik povjerenstva)
• Committee member: Borislav Belev (član povjerenstva)
• Committee member: Vesna Bišof (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Clinical Oncology); Zagreb
• Defense date and country: 2021-07-16, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Oncology

Abstract

Karcinom orofarinksa je jedan od češćih malignih tumora glave i vrata. Zbog porasta
incidencije, posebno u razvijenim zemljama svijeta, predstavlja važan
javnozdravstveni problem. Kao etiološki čimbenici rizika, ističu se posebno
konzumacija alkohola i prekomjerno pušenje, kao i infekcija HPV virusom. Porast
incidencije HPV pozitivnih karcinoma orofarinksa u razvijenim zemljama obilježen je
češćim javljanjem ovog karcinoma kod osoba mlađe dobi.
Karcinomi pločastih stanica su najčešći patohistološki tip tumora orofarinksa. Često
su asimptomatski u ranim fazama bolesti, a mogu se manifestirati kao
hiperkeratotičke naslage, leukoplakije ili ulkusi. U lokalno uznapredovaloj fazi bolesti
se mogu manifestirati i uvećanim limfnim čvorovima vrata.
Liječenje karcinoma orofarinksa je kompleksno i može predstavljati izazov.
Donošenje odluke o optimalnom terapijskom pristupu zahtijeva multidisciplinarni
pristup. Iako razlikujemo HPV pozitivne i negativne karcinome, njihovo se liječenje za
sada ne razlikuje. Liječenje karcinoma orofarinksa ovisi o stadiju bolesti, a može
uključivati jedan ili više različitih terapijskih modaliteta: kirurško liječenje,
radioterapiju, ciljanu terapiju i imunoterapiju.

Abstract (english)

Oropharyngeal cancer represents one of the most common malignant tumors of the
head and neck. Due to the increase in incidence, especially in the developed
countries, it is an important public health problem. Alcohol consumption and
excessive smoking, as well as the HPV infection, stand out as etiological risk factors.
The increase in the incidence of HPV-positive oropharyngeal cancers in developed
countries is marked by a more frequent occurrence of this cancer in younger people.
Squamous cell carcinomas are the most common pathohistological type of
oropharyngeal cancers. They are often asymptomatic in the early stages of the
disease, and may manifest as hyperkeratotic deposits, leukoplakia or ulcera. In the
locally advanced stage, the disease can also manifest by enlarged lymph nodes in
the neck.
The treatment of oropharyngeal cancer is complex and can be challenging. The
decision on an ideal therapeutic approach requires a multidisciplinary approach.
Although we distinguish between HPV positive and negative cancers, their treatment
does not differ for now. The treatment of oropharyngeal cancer depends on the stage
of the disease and may include one or more different therapeutic modalities: surgery,
radiotherapy, target therapy and immunotherapy.

• Keywords: karcinom orofarinksa; radioterapija; kirurško liječenje
• Keywords (english): oropharingeal cancer; radiotherapy; surgery
• Language: croatian
• URN:NBN: urn:nbn:hr:105:062996
• Study programme: Title: Studies in Nursing; Study programme type: university; Study level: graduate; Academic / professional title: magistar/magistra sestrinstva (magistar/magistra sestrinstva)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2022-07-08 11:51:49