prikaz prve stranice dokumenta Multistep pathogenesis of chronic myelomonocytic leukemia in patients
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Scientific paper - Original scientific paper
Multistep pathogenesis of chronic myelomonocytic leukemia in patients
European Journal of Haematology, 109 (2022), 1; 50-57. https://doi.org/10.1111/ejh.13768
Geissler, Klaus; Jäger, Eva; Barna, Agnes; Gurbisz, Michael; Marschon, Renate; Graf, Temeida; Nösslinger, Thomas; Pfeilstöcker, Michael; Machherndl‐Spandl, Sigrid; Stauder, Reinhard; Zebisch, Armin; Sill, Heinz; Öhler, Leopold; Kušec, Rajko; Hoermann, Gregor; Valent, Peter More authors...

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Geissler, K., Jäger, E., Barna, A., Gurbisz, M., Marschon, R., Graf, T. ... Valent, P. (2022). Multistep pathogenesis of chronic myelomonocytic leukemia in patients. European Journal of Haematology, 109. (1), 50-57. doi: 10.1111/ejh.13768

Geissler, Klaus, et al. "Multistep pathogenesis of chronic myelomonocytic leukemia in patients." European Journal of Haematology, vol. 109, no. 1, 2022, pp. 50-57. https://doi.org/10.1111/ejh.13768

Geissler, Klaus, Eva Jäger, Agnes Barna, Michael Gurbisz, Renate Marschon, Temeida Graf, Thomas Nösslinger, et al. "Multistep pathogenesis of chronic myelomonocytic leukemia in patients." European Journal of Haematology 109, no. 1 (2022): 50-57. https://doi.org/10.1111/ejh.13768

Geissler, K., et al. (2022) 'Multistep pathogenesis of chronic myelomonocytic leukemia in patients', European Journal of Haematology, 109(1), pp. 50-57. doi: 10.1111/ejh.13768

Geissler K, Jäger E, Barna A, Gurbisz M, Marschon R, Graf T, and sur.. Multistep pathogenesis of chronic myelomonocytic leukemia in patients. European Journal of Haematology [Internet]. 2022 July [cited 2024 October 09];109(1):50-57. doi: 10.1111/ejh.13768

K. Geissler, et al., "Multistep pathogenesis of chronic myelomonocytic leukemia in patients", European Journal of Haematology, vol. 109, no. 1, pp. 50-57, July 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:274303. [Accessed: 09 October 2024]

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Metadata
Title (english)Multistep pathogenesis of chronic myelomonocytic leukemia in patients
AuthorKlaus Geissler
AuthorEva Jäger
AuthorAgnes Barna
AuthorMichael Gurbisz
AuthorRenate Marschon
AuthorTemeida Graf
AuthorThomas Nösslinger
AuthorMichael Pfeilstöcker
AuthorSigrid Machherndl‐Spandl
AuthorReinhard Stauder
AuthorArmin Zebisch
AuthorHeinz Sill
AuthorLeopold Öhler
AuthorRajko Kušec
AuthorGregor Hoermann
AuthorPeter Valent
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Background: A multistep pathogenesis of myeloid leukemia including mutations in epigenetic, spliceosome, and signaling genes has been recently demonstrated in a preclinical model but is poorly validated in patients. ----- Methods: Clinical, phenotypic, and biologic features were compared between three distinct molecularly defined CMML cohorts including TET2 monomutated patients (T, n = 10), TET2/SRSF2 bimutated patients (TS, n = 19), and patients who had NRAS mutations in addition to TET2/SRSF2 comutations (TSN, n = 14). ----- Results: Median survival was 90, 45, and 9 months, respectively (p = .001). Whereas no patient in the T and TS group transformed into acute myeloid leukemia (AML), 6/14 patients in the TSN group had AML at study entry or transformed during follow-up. Leukocyte counts, blast cell counts, and LDH levels were significantly higher in TSN vs. TS and T, respectively, whereas hemoglobin and platelet values were not significantly different. Increased growth factor-independent myeloid colony formation was restricted to TSN but not found in T and TS, respectively. The proportion of patients showing in vitro myelomonocytic skewing in T, TS, and TSN was 0%, 56%, and 100%, respectively (p = .010). ----- Conclusion: Our results demonstrate that the model of multistep pathogenesis in CMML can be recapitulated in patients regarding clinical, phenotypic, and biologic features.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleEuropean Journal of Haematology
Numberingvol. 109, no. 1, pp. 50-57
p-ISSN0902-4441
e-ISSN1600-0609
DOIhttps://doi.org/10.1111/ejh.13768
URN:NBNurn:nbn:hr:105:274303
Publication2022-07
Document URLhttps://onlinelibrary.wiley.com/doi/10.1111/ejh.13768
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2022-09-30 09:18:55